Med12 Gene Search Result

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5 records found for search term Med12

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RGD ID	Symbol	Name	Description	Chr	Start	Stop	Species	Annotations	Match	Type
1350145	MED12	mediator complex subunit 12	The initiation of transcription is controlled in part by a large protein assembly known as the preinitiation complex. A component of this preinitiation complex is a 1.2 MDa protein aggregate called Mediator. This Mediator component binds with a CDK8 subcomplex which contains the protein encoded by t ... (more) his gene, mediator complex subunit 12 (MED12), along with MED13, CDK8 kinase, and cyclin C. The CDK8 subcomplex modulates Mediator-polymerase II interactions and thereby regulates transcription initiation and reinitation rates. The MED12 protein is essential for activating CDK8 kinase. Defects in this gene cause X-linked Opitz-Kaveggia syndrome, also known as FG syndrome, and Lujan-Fryns syndrome. [provided by RefSeq, Aug 2009]	X	71118596	71142450	Human	667	symbol , COSMIC , description , Human Proteome Map , old_gene_symbol	gene, protein-coding, REVIEWED [RefSeq]
16552801	AC004866.2	pseudogene similar to part of mediator complex subunit 12 MED12					Human		name	gene, unprocessed_pseudogene
16552615	AC004866.1	pseudogene similar to part of mediator complex subunit 12 MED12					Human		name	gene, processed_pseudogene
1352033	MED12L	mediator complex subunit 12L	The protein encoded by this gene is part of the Mediator complex, which is involved in transcriptional coactivation of nearly all RNA polymerase II-dependent genes. The Mediator complex links gene-specific transcriptional activators with the basal transcription machinery. [provided by RefSeq, May 20 ... (more) 10]	3	151085664	151436653	Human	136	symbol , COSMIC , Human Proteome Map	gene, protein-coding, VALIDATED [RefSeq]
1312495	MED13	mediator complex subunit 13	This gene encodes a component of the mediator complex (also known as TRAP, SMCC, DRIP, or ARC), a transcriptional coactivator complex thought to be required for the expression of almost all genes. The mediator complex is recruited by transcriptional activators or nuclear receptors to induce gene exp ... (more) ression, possibly by interacting with RNA polymerase II and promoting the formation of a transcriptional pre-initiation complex. The product of this gene is proposed to form a sub-complex with MED12, cyclin C, and CDK8 that can negatively regulate transactivation by mediator. [provided by RefSeq, Jul 2008]	17	61942605	62065278	Human	159	description	gene, protein-coding, REVIEWED [RefSeq]