| 1316562 | MBD3 | methyl-CpG binding domain protein 3 | DNA methylation is the major modification of eukaryotic genomes and plays an essential role in mammalian development. This gene belongs to a family of nuclear proteins which are characterized by the presence of a methyl-CpG binding domain (MBD). The encoded protein is a subunit of the NuRD, a multis ubunit complex containing nucleosome remodeling and histone deacetylase activities. Unlike the other family members, the encoded protein is not capable of binding to methylated DNA. The protein mediates the association of metastasis-associated protein 2 with the core histone deacetylase complex. Alternative splicing results in multiple transcript variants of this gene. [provided by RefSeq, Jul 2013] | 19 | 1573596 | 1592865 | Human | 149 | symbol , old_gene_name , COSMIC , Human Proteome Map | gene, protein-coding, REVIEWED [RefSeq] |
| 1313538 | DPEP3 | dipeptidase 3 | This gene encodes a membrane-bound glycoprotein from the family of dipeptidases involved in hydrolytic metabolism of various dipeptides, including penem and carbapenem beta-lactam antibiotics. This gene is located on chromosome 16 in a cluster with another member of this family. Alternatively splice d transcript variants that encode different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] | 16 | 67975663 | 67980499 | Human | 45 | old_gene_symbol | gene, protein-coding, REVIEWED [RefSeq] |
| 16564420 | AC005943.1 | novel transcript, readthrough between UQCR11 and MBD3 | | | | | Human | | name | gene, protein-coding |
| 5477527 | MBD3L3 | methyl-CpG binding domain protein 3 like 3 | Predicted to enable methyl-CpG binding activity. Predicted to be involved in DNA methylation-dependent constitutive heterochromatin formation and negative regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Jul 2025] | 19 | 7056207 | 7058676 | Human | 10 | symbol , old_gene_name , COSMIC , Human Proteome Map | gene, protein-coding, VALIDATED [RefSeq] |
| 5477533 | MBD3L4 | methyl-CpG binding domain protein 3 like 4 | This gene encodes a member of a family of proteins that are related to methyl-CpG-binding proteins but lack the methyl-CpG binding domain. There is no definitive support for transcription of this locus, and the transcript structure is inferred from other family members. [provided by RefSeq, Aug 2009 ] | 19 | 7037749 | 7040179 | Human | 8 | symbol , old_gene_name , COSMIC , Human Proteome Map | gene, protein-coding, INFERRED [RefSeq] |
| 5477562 | MBD3L5 | methyl-CpG binding domain protein 3 like 5 | Predicted to enable methyl-CpG binding activity. Predicted to be involved in DNA methylation-dependent constitutive heterochromatin formation and negative regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Jul 2025] | 19 | 7030578 | 7033011 | Human | 8 | symbol , old_gene_name , COSMIC , Human Proteome Map | gene, protein-coding, VALIDATED [RefSeq] |
| 1317930 | MBD3L1 | methyl-CpG binding domain protein 3 like 1 | This gene encodes a protein that is related to methyl-CpG-binding proteins but lacks the methyl-CpG binding domain. The protein is localized to discrete areas in the nucleus, and expression appears to be restricted to round spermatids, suggesting that the protein plays a role in the postmeiotic stag es of male germ cell development. [provided by RefSeq, Jul 2008] | 19 | 8832377 | 8843319 | Human | 18 | symbol , old_gene_name , COSMIC , Human Proteome Map , old_gene_symbol | gene, protein-coding, REVIEWED [RefSeq] |
| 1601828 | MBD3L2 | methyl-CpG binding domain protein 3 like 2 | This gene encodes a protein that is related to methyl-CpG-binding proteins but lacks the methyl-CpG binding domain. The protein has been found in germ cell tumors and some somatic tissues. [provided by RefSeq, Jul 2008] | 19 | 7049321 | 7051735 | Human | 24 | symbol , old_gene_name , COSMIC , Human Proteome Map | gene, protein-coding, REVIEWED [RefSeq] |
| 12859063 | MBD3L2B | methyl-CpG binding domain protein 3 like 2B | Predicted to enable methyl-CpG binding activity. Predicted to be involved in DNA methylation-dependent constitutive heterochromatin formation and negative regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Jul 2025] | 19 | 7018969 | 7021431 | Human | 5 | symbol , COSMIC , Human Proteome Map | gene, protein-coding, VALIDATED [RefSeq] |
| 1312368 | MBD2 | methyl-CpG binding domain protein 2 | DNA methylation is the major modification of eukaryotic genomes and plays an essential role in mammalian development. Human proteins MECP2, MBD1, MBD2, MBD3, and MBD4 comprise a family of nuclear proteins related by the presence in each of a methyl-CpG binding d omain (MBD). Each of these proteins, with the exception of MBD3, is capable of binding specifically to methylated DNA. MECP2, MBD1 and MBD2 can also repress transcription from methylated gene promoters. The protein encoded by this gene may function as a mediator of the biological consequences of the methylation signal. It is also reported that the this protein functions as a demethylase to activate transcription, as DNA methylation causes gene silencing. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2011] | 18 | 54151606 | 54224669 | Human | 190 | description | gene, protein-coding, REVIEWED [RefSeq] |
| 1349232 | MECP2 | methyl-CpG binding protein 2 | DNA methylation is the major modification of eukaryotic genomes and plays an essential role in mammalian development. Human proteins MECP2, MBD1, MBD2, MBD3, and MBD4 comprise a family of nuclear proteins related by the presence in each of a methyl-CpG binding d omain (MBD). Each of these proteins, with the exception of MBD3, is capable of binding specifically to methylated DNA. MECP2, MBD1 and MBD2 can also repress transcription from methylated gene promoters. In contrast to other MBD family members, MECP2 is X-linked and subject to X inactivation. MECP2 is dispensible in stem cells, but is essential for embryonic development. MECP2 gene mutations are the cause of most cases of Rett syndrome, a progressive neurologic developmental disorder and one of the most common causes of cognitive disability in females. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Oct 2015] | X | 154021573 | 154097717 | Human | 1722 | description | gene, protein-coding, REVIEWED [RefSeq] |
| 16565176 | AC008734.2 | novel transcript, sense intronic to MBD3L1 | | | | | Human | | name | gene, lncrna |
