Map2k4 Gene Search Result

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4 records found for search term Map2k4

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RGD ID	Symbol	Name	Description	Chr	Start	Stop	Species	Annotations	Match	Type
1316000	MAP2K4	mitogen-activated protein kinase kinase 4	This gene encodes a member of the mitogen-activated protein kinase (MAPK) family. Members of this family act as an integration point for multiple biochemical signals and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation, and develop ... (more) ment. They form a three-tiered signaling module composed of MAPKKKs, MAPKKs, and MAPKs. This protein is phosphorylated at serine and threonine residues by MAPKKKs and subsequently phosphorylates downstream MAPK targets at threonine and tyrosine residues. A similar protein in mouse has been reported to play a role in liver organogenesis. A pseudogene of this gene is located on the long arm of chromosome X. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]	17	12020877	12143828	Human	290	symbol , COSMIC , Human Proteome Map	gene, protein-coding, REVIEWED [RefSeq]
6480555	MAP2K4P1	mitogen-activated protein kinase kinase 4 pseudogene 1	INTERACTS WITH aristolochic acid A; benzo[a]pyrene; doxorubicin	X	73524275	73563085	Human	7	symbol , COSMIC , Human Proteome Map	gene, pseudo, VALIDATED [RefSeq]
1319782	MAP3K7	mitogen-activated protein kinase kinase kinase 7	The protein encoded by this gene is a member of the serine/threonine protein kinase family. This kinase mediates the signaling transduction induced by TGF beta and morphogenetic protein (BMP), and controls a variety of cell functions including transcription regulation and apoptosis. In response to I ... (more) L-1, this protein forms a kinase complex including TRAF6, MAP3K7P1/TAB1 and MAP3K7P2/TAB2; this complex is required for the activation of nuclear factor kappa B. This kinase can also activate MAPK8/JNK, MAP2K4/MKK4, and thus plays a role in the cell response to environmental stresses. Four alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]	6	90513579	90587072	Human	672	description	gene, protein-coding, REVIEWED [RefSeq]
1313282	MAP4K4	mitogen-activated protein kinase kinase kinase kinase 4	The protein encoded by this gene is a member of the serine/threonine protein kinase family. This kinase has been shown to specifically activate MAPK8/JNK. The activation of MAPK8 by this kinase is found to be inhibited by the dominant-negative mutants of MAP3K7/TAK1, MAP2K4 ... (more) AP2K4/MKK4, and MAP2K7/MKK7, which suggests that this kinase may function through the MAP3K7-MAP2K4-MAP2K7 kinase cascade, and mediate the TNF-alpha signaling pathway. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]	2	101697707	101894690	Human	242	description	gene, protein-coding, REVIEWED [RefSeq]