This gene encodes a mitochondrially-localized protein that has sequence similarity to prokaryotic beta-lactamases. Many of the residues responsible for beta-lactamase activity are not conserved in this protein, suggesting it may have a different enzymatic function. Increased expression of the relate
d mouse gene was found to be associated with obesity. Alternative splicing results in multiple transcript variants encoding different protein isoforms. [provided by RefSeq, Dec 2013]
15
63121861
63142061
Human
109
symbol , old_gene_name , COSMIC , Human Proteome Map
Enables RNA endonuclease activity; single-stranded RNA binding activity; and zinc ion binding activity. Located in mitochondrial matrix. [provided by Alliance of Genome Resources, Jul 2025]
8
70637266
70669185
Human
131
symbol , old_gene_name , COSMIC , Human Proteome Map