| 70506 | IGF1 | insulin like growth factor 1 | The protein encoded by this gene is similar to insulin in function and structure and is a member of a family of proteins involved in mediating growth and development. The encoded protein is processed from a precursor, bound by a specific receptor, and secreted. Defects in this gene are a cause of in sulin-like growth factor I deficiency. Alternative splicing results in multiple transcript variants encoding different isoforms that may undergo similar processing to generate mature protein. [provided by RefSeq, Sep 2015] | 12 | 102395874 | 102481839 | Human | 1422 | symbol , COSMIC , Human Proteome Map , old_gene_symbol | gene, protein-coding, REVIEWED [RefSeq] |
| 68997 | IGF1R | insulin like growth factor 1 receptor | This receptor binds insulin-like growth factor with a high affinity. It has tyrosine kinase activity. The insulin-like growth factor I receptor plays a critical role in transformation events. Cleavage of the precursor generates alpha and beta subunits. It is highly overexpressed in most malignant ti ssues where it functions as an anti-apoptotic agent by enhancing cell survival. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, May 2014] | 15 | 98648539 | 98964530 | Human | 936 | symbol , old_gene_name , COSMIC , Human Proteome Map | gene, protein-coding, REVIEWED [RefSeq] |
| 617154640 | IGF1R-AS2 | IGF1R antisense RNA 2 | | | | | Human | | symbol , GTEx , COSMIC , name , Human Proteome Map | gene, ncrna |
| 9589867 | IRAIN | IGF1R antisense imprinted non-protein coding RNA | This gene expresses a long non-coding RNA in antisense to the insulin-like growth factor type I receptor (IGF1R) gene. This transcript is imprinted and expressed from the paternal allele. It interacts with chromatin and may promote long-range DNA interactions th at influence the regulation of gene expression. [provided by RefSeq, Nov 2015] | 15 | 98645863 | 98650787 | Human | | name , description , old_gene_symbol | gene, ncrna, REVIEWED [RefSeq] |
| 735623 | AKT3 | AKT serine/threonine kinase 3 | The protein encoded by this gene is a member of the AKT, also called PKB, serine/threonine protein kinase family. AKT kinases are known to be regulators of cell signaling in response to insulin and growth factors. They are involved in a wide variety of biological processes including cell proliferat ion, differentiation, apoptosis, tumorigenesis, as well as glycogen synthesis and glucose uptake. This kinase has been shown to be stimulated by platelet-derived growth factor (PDGF), insulin, and insulin-like growth factor 1 (IGF1). Alternatively splice transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Jul 2008] | 1 | 243488233 | 243851079 | Human | 353 | description | gene, protein-coding, REVIEWED [RefSeq] |
| 1319124 | EHD1 | EH domain containing 1 | This gene belongs to a highly conserved gene family encoding EPS15 homology (EH) domain-containing proteins. The protein-binding EH domain was first noted in EPS15, a substrate for the epidermal growth factor receptor. The EH domain has been shown to be an important motif in proteins involved in pro tein-protein interactions and in intracellular sorting. The protein encoded by this gene is thought to play a role in the endocytosis of IGF1 receptors. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Sep 2013] | 11 | 64851642 | 64879693 | Human | 224 | description | gene, protein-coding, REVIEWED [RefSeq] |
| 1352815 | SOCS2 | suppressor of cytokine signaling 2 | This gene encodes a member of the suppressor of cytokine signaling (SOCS) family. SOCS family members are cytokine-inducible negative regulators of cytokine receptor signaling via the Janus kinase/signal transducer and activation of transcription pathway (the JAK/STAT pathway). SOCS family proteins interact with major molecules of signaling complexes to block further signal transduction, in part, by proteasomal depletion of receptors or signal-transducing proteins via ubiquitination. The expression of this gene can be induced by a subset of cytokines, including erythropoietin, GM-CSF, IL10, interferon (IFN)-gamma and by cytokine receptors such as growth horomone receptor. The protein encoded by this gene interacts with the cytoplasmic domain of insulin-like growth factor-1 receptor (IGF1R) and is thought to be involved in the regulation of IGF1R mediated cell signaling. This gene has pseudogenes on chromosomes 20 and 22. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2012] | 12 | 93569969 | 93626236 | Human | 320 | description | gene, protein-coding, REVIEWED [RefSeq] |
| 16572283 | AC055807.1 | novel transcript, antisense to IGF1R | | | | | Human | | name | gene, lncrna |
| 16562312 | AC069029.1 | novel transcript, antisense to IGF1R | | | | | Human | | name | gene, lncrna |
| 16568425 | AC118658.1 | novel transcript, sense intronic to IGF1R | | | | | Human | | name | gene, lncrna |
| 16562229 | AC036108.1 | novel transcript, antisense to IGF1R and SYNM | | | | | Human | | name | gene, lncrna |
| 9589849 | LUNAR1 | leukemia-associated non-coding IGF1R activator RNA 1 | This gene is thought to produce a functional long non-coding RNA. It is regulated by Notch and is overexpressed in T cell acute lymphoblastic leukemia. The transcript acts as a positive regulator of cell division by promoting expression of the insulin-like growth factor type I receptor (IGF1 'font-weight:700;'>IGF1R) gene. [provided by RefSeq, Feb 2015] | 15 | 99014704 | 99031050 | Human | 3 | name , description | gene, ncrna, VALIDATED [RefSeq] |
