Grap Gene Search Result

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11 records found for search term Grap

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RGD ID	Symbol	Name	Description	Chr	Start	Stop	Species	Annotations	Match	Type
1353606	GRAP	GRB2 related adaptor protein	This gene encodes a member of the GRB2/Sem5/Drk family and functions as a cytoplasmic signaling protein which contains an SH2 domain flanked by two SH3 domains. The SH2 domain interacts with ligand-activated receptors for stem cell factor and erythropoietin, and facilitates the formation of a stable ... (more) complex with the BCR-ABL oncoprotein. This protein also associates with the Ras guanine nucleotide exchange factor SOS1 (son of sevenless homolog 1) through its N-terminal SH3 domain. In general, it couples signals from receptor and cytoplasmic tyrosine kinases to the Ras signaling pathway. [provided by RefSeq, Jul 2012]	17	19020656	19051373	Human	82	symbol , COSMIC , Human Proteome Map	gene, protein-coding, REVIEWED [RefSeq]
1316895	GRAP2	GRB2 related adaptor protein 2	This gene encodes a member of the GRB2/Sem5/Drk family. This member is an adaptor-like protein involved in leukocyte-specific protein-tyrosine kinase signaling. Like its related family member, GRB2-related adaptor protein (GRAP), this protein contains an SH2 dom ... (more) ain flanked by two SH3 domains. This protein interacts with other proteins, such as GRB2-associated binding protein 1 (GAB1) and the SLP-76 leukocyte protein (LCP2), through its SH3 domains. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Apr 2014]	22	39893820	39973721	Human	97	symbol , COSMIC , description , Human Proteome Map , old_gene_symbol	gene, protein-coding, REVIEWED [RefSeq]
16553982	AC092810.1	GRB2-related adaptor protein (GRAP) pseudogene					Human		name	gene, processed_pseudogene
16568211	AP006248.1	GRB2-related adaptor protein (GRAP) pseudogene					Human		name	gene, unprocessed_pseudogene
3255320	GRAPL	GRB2 related adaptor protein like	Predicted to enable receptor tyrosine kinase binding activity and signaling adaptor activity. Predicted to be involved in cell migration and enzyme-linked receptor protein signaling pathway. Predicted to be located in cytosol. Predicted to be active in cytoplasm. [provided by Alliance of Genome Reso ... (more) urces, Jul 2025]	17	19127589	19159187	Human	8	symbol , old_gene_name , COSMIC , Human Proteome Map , old_gene_symbol	gene, protein-coding, VALIDATED [RefSeq]
16563546	GRAPLDR	GRAPL long non-coding downstream RNA					Human		symbol , COSMIC , name , Human Proteome Map	gene, lncrna
38648746	GRAPL-AS1	GRAPL antisense RNA 1		17	19154646	19162624	Human		symbol , GTEx , COSMIC , name , Human Proteome Map	gene, ncrna, VALIDATED [RefSeq]
16550961	AC007952.1	novel transcript, antisense to GRAPL	INVOLVED IN RNA processing (inferred); FOUND IN nucleolus (inferred)				Human	2	name	gene, lncrna
16563554	AC007952.6	novel transcript, antisense to GRAPL					Human		name	gene, lncrna
1312246	CCNDBP1	cyclin D1 binding protein 1	This gene was identified by the interaction of its gene product with Grap2, a leukocyte-specific adaptor protein important for immune cell signaling. The protein encoded by this gene was shown to interact with cyclin D. Transfection of this gene in cells was rep ... (more) orted to reduce the phosphorylation of Rb gene product by cyclin D-dependent protein kinase, and inhibit E2F1-mediated transcription activity. This protein was also found to interact with helix-loop-helix protein E12 and is thought to be a negative regulator of liver-specific gene expression. Several alternatively spliced variants have been found for this gene. [provided by RefSeq, Apr 2009]	15	43185403	43197177	Human	76	old_gene_name , description	gene, protein-coding, REVIEWED [RefSeq]
1603038	BPNT2	3'(2'), 5'-bisphosphate nucleotidase 2	This gene encodes a member of the inositol monophosphatase family. The encoded protein is localized to the Golgi apparatus and catalyzes the hydrolysis of phosphoadenosine phosphate (PAP) to adenosine monophosphate (AMP). Mutations in this gene are a cause of GRAP ... (more) n>P type chondrodysplasia with joint dislocations, and a pseudogene of this gene is located on the long arm of chromosome 1. [provided by RefSeq, Dec 2011]	8	56957931	56993867	Human	208	description	gene, protein-coding, REVIEWED [RefSeq]