Fbxo30 Gene Search Result

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3 records found for search term Fbxo30

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RGD ID	Symbol	Name	Description	Chr	Start	Stop	Species	Annotations	Match	Type
1347238	FBXO30	F-box protein 30	This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of the ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependen ... (more) t ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbxs class and it is upregulated in nasopharyngeal carcinoma. [provided by RefSeq, Jul 2008]	6	145793502	145814795	Human	140	symbol , COSMIC , Human Proteome Map	gene, protein-coding, REVIEWED [RefSeq]
1347453	FBXW7	F-box and WD repeat domain containing 7	This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ub ... (more) iquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene was previously referred to as FBX30, and belongs to the Fbws class; in addition to an F-box, this protein contains 7 tandem WD40 repeats. This protein binds directly to cyclin E and probably targets cyclin E for ubiquitin-mediated degradation. Mutations in this gene are detected in ovarian and breast cancer cell lines, implicating the gene's potential role in the pathogenesis of human cancers. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2012]	4	152320544	152536092	Human	351	old_gene_symbol	gene, protein-coding, REVIEWED [RefSeq]
18937004	EPM2A-DT	EPM2A divergent transcript	ASSOCIATED WITH epilepsy; progressive myoclonus epilepsy; INTERACTS WITH benzo[a]pyrene; okadaic acid; perfluorooctanoic acid	6	145734869	145886585	Human	7	old_gene_name , old_gene_symbol	gene, ncrna, VALIDATED [RefSeq]