| 1313642 | EPS15 | epidermal growth factor receptor pathway substrate 15 | This gene encodes a protein that is part of the EGFR pathway. The protein is present at clatherin-coated pits and is involved in receptor-mediated endocytosis of EGF. Notably, this gene is rearranged with the HRX/ALL/MLL gene in acute myelogeneous leukemias. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, May 2009] | 1 | 51354263 | 51519266 | Human | 169 | symbol , COSMIC , Human Proteome Map | gene, protein-coding, REVIEWED [RefSeq] |
| 14700575 | EPS15-AS1 | EPS15 antisense RNA 1 | | 1 | 51518272 | 51579310 | Human | | symbol , COSMIC , name , Human Proteome Map | gene, ncrna, VALIDATED [RefSeq] |
| 1351510 | EPN2 | epsin 2 | This gene encodes a protein which interacts with clathrin and adaptor-related protein complex 2, alpha 1 subunit. The protein is found in a brain-derived clathrin-coated vesicle fraction and localizes to the peri-Golgi region and the cell periphery. The protein is thought to be involved in clathrin- mediated endocytosis. Alternate splicing of this gene results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008] | 17 | 19237366 | 19336715 | Human | 113 | old_gene_name | gene, protein-coding, VALIDATED [RefSeq] |
| 1345399 | EPS15L1 | epidermal growth factor receptor pathway substrate 15 like 1 | Enables cadherin binding activity. Predicted to be involved in endosomal transport and synaptic vesicle endocytosis. Located in membrane. [provided by Alliance of Genome Resources, Apr 2025] | 19 | 16355247 | 16472012 | Human | 96 | symbol , old_gene_name , COSMIC , Human Proteome Map , old_gene_symbol | gene, protein-coding, VALIDATED [RefSeq] |
| 1348027 | EPS15P1 | epidermal growth factor receptor pathway substrate 15 pseudogene 1 | INTERACTS WITH lipopolysaccharide; S-(1,2-dichlorovinyl)-L-cysteine; zinc atom | 7 | 46781990 | 46783420 | Human | 5 | symbol , COSMIC , Human Proteome Map , old_gene_symbol | gene, pseudo, INFERRED [RefSeq] |
| 1319124 | EHD1 | EH domain containing 1 | This gene belongs to a highly conserved gene family encoding EPS15 homology (EH) domain-containing proteins. The protein-binding EH domain was first noted in EPS15, a substrate for the epidermal growth factor receptor. The E H domain has been shown to be an important motif in proteins involved in protein-protein interactions and in intracellular sorting. The protein encoded by this gene is thought to play a role in the endocytosis of IGF1 receptors. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Sep 2013] | 11 | 64851642 | 64879693 | Human | 224 | description | gene, protein-coding, REVIEWED [RefSeq] |
| 1315293 | AGFG2 | ArfGAP with FG repeats 2 | This gene is a member of the HIV-1 Rev binding protein (HRB) family and encodes a protein with one Arf-GAP zinc finger domain, several phe-gly (FG) motifs, and four asn-pro-phe (NPF) motifs. This protein interacts with Eps15 homology (EH) domains and plays a rol e in the Rev export pathway, which mediates the nucleocytoplasmic transfer of proteins and RNAs. Alternatively spliced transcript variants have been described, but their biological validity has not been determined. [provided by RefSeq, Feb 2013] | 7 | 100539203 | 100568220 | Human | 107 | description | gene, protein-coding, REVIEWED [RefSeq] |
| 1346487 | EHBP1 | EH domain binding protein 1 | This gene encodes an Eps15 homology domain binding protein. The encoded protein may play a role in endocytic trafficking. A single nucleotide polymorphism in this gene is associated with an aggressive form of prostate cancer. Alternate splicing results in multip le transcript variants. [provided by RefSeq, Feb 2010] | 2 | 62673878 | 63046487 | Human | 143 | description | gene, protein-coding, REVIEWED [RefSeq] |
| 737072 | ITSN1 | intersectin 1 | The protein encoded by this gene is a cytoplasmic membrane-associated protein that indirectly coordinates endocytic membrane traffic with the actin assembly machinery. In addition, the encoded protein may regulate the formation of clathrin-coated vesicles and could be involved in synaptic vesicle re cycling. This protein has been shown to interact with dynamin, CDC42, SNAP23, SNAP25, SPIN90, EPS15, EPN1, EPN2, and STN2. Multiple transcript variants encoding different isoforms have been found for this gene, but the full-length nature of only two of them have been characterized so far. [provided by RefSeq, Jul 2008] | 21 | 33642501 | 33899861 | Human | 255 | description | gene, protein-coding, REVIEWED [RefSeq] |
| 1348962 | NUMB | NUMB endocytic adaptor protein | The protein encoded by this gene plays a role in the determination of cell fates during development. The encoded protein, whose degradation is induced in a proteasome-dependent manner by MDM2, is a membrane-bound protein that has been shown to associate with EPS15 n>, LNX1, and NOTCH1. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2016] | 14 | 73275216 | 73458546 | Human | 153 | description | gene, protein-coding, REVIEWED [RefSeq] |
| 16564796 | AC020917.2 | novel transcript, antisense EPS15L1 | | | | | Human | | name | gene, lncrna |
