Col18a1 Gene Search Result

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3 records found for search term Col18a1

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RGD ID	Symbol	Name	Description	Chr	Start	Stop	Species	Annotations	Match	Type
736032	COL18A1	collagen type XVIII alpha 1 chain	This gene encodes the alpha chain of type XVIII collagen. This collagen is one of the multiplexins, extracellular matrix proteins that contain multiple triple-helix domains (collagenous domains) interrupted by non-collagenous domains. A long isoform of the protein has an N-terminal domain that is ho ... (more) mologous to the extracellular part of frizzled receptors. Proteolytic processing at several endogenous cleavage sites in the C-terminal domain results in production of endostatin, a potent antiangiogenic protein that is able to inhibit angiogenesis and tumor growth. Mutations in this gene are associated with Knobloch syndrome. The main features of this syndrome involve retinal abnormalities, so type XVIII collagen may play an important role in retinal structure and in neural tube closure. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2014]	21	45405165	45513720	Human	427	symbol , COSMIC , Human Proteome Map	gene, protein-coding, REVIEWED [RefSeq]
1350562	COL18A1-AS1	COL18A1 antisense RNA 1	INTERACTS WITH 17beta-estradiol; valproic acid	21	45419716	45425070	Human	2	symbol , COSMIC , name , Human Proteome Map	gene, ncrna, VALIDATED [RefSeq]
6766705	COL18A1-AS2	COL18A1 antisense RNA 2	INTERACTS WITH aflatoxin B1; benzo[a]pyrene; benzo[e]pyrene	21	45407386	45410065	Human	4	symbol , COSMIC , name , Human Proteome Map	gene, ncrna, VALIDATED [RefSeq]