| 620605 | Zp2 | zona pellucida glycoprotein 2 | ENCODES a protein that exhibits acrosin binding (ortholog); identical protein binding (ortholog); structural constituent of egg coat (ortholog); INVOLVED IN binding of sperm to zona pellucida (ortholog); humoral immune response mediated by circulating immunoglobulin (ortholog); prevention of polyspe rmy (ortholog); ASSOCIATED WITH Oocyte/Zygote/Embryo Maturation Arrest 6 (ortholog); FOUND IN egg coat (ortholog); endoplasmic reticulum (ortholog); extracellular matrix (ortholog); INTERACTS WITH 1,2-dimethylhydrazine; bis(2-ethylhexyl) phthalate; bisphenol A | 1 | 183944840 | 183956619 | Rat | 68 | symbol , old_gene_name , PhenoGen | gene, protein-coding, PROVISIONAL [RefSeq] |
| 732923 | Zp2 | zona pellucida glycoprotein 2 | This gene encodes a member of the zona pellucida family of glycoproteins that play an important role in the survival of growing oocytes, successful fertilization and the passage of early embryos through the oviduct. The encoded preproprotein undergoes proteolytic processing to generate the mature po lypeptide that is incorporated into the extracellular matrix surrounding mouse oocytes. Mice lacking the encoded protein develop defective zonae pellucidae that disrupt folliculogenesis, fertility and development. [provided by RefSeq, Sep 2016] | 7 | 119725985 | 119744514 | Mouse | 73 | symbol , old_gene_name , PhenoGen | gene, protein-coding, REVIEWED [RefSeq] |
| 735363 | ZP2 | zona pellucida glycoprotein 2 | The zona pellucida is an extracellular matrix that surrounds the oocyte and early embryo. It is composed of three glycoproteins with various functions during fertilization and preimplantation development. The glycosylated mature peptide is one of the structural components of the zona pellucida and f unctions in secondary binding and penetration of acrosome-reacted spermatozoa. Female mice lacking this gene do not form a stable zona matrix and are sterile. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2014] | 16 | 21197450 | 21214510 | Human | 78 | symbol , old_gene_name , COSMIC , Human Proteome Map | gene, protein-coding, REVIEWED [RefSeq] |
| 8864865 | Zp2 | zona pellucida glycoprotein 2 | ENCODES a protein that exhibits acrosin binding (ortholog); identical protein binding (ortholog); structural constituent of egg coat (ortholog); INVOLVED IN binding of sperm to zona pellucida (ortholog); humoral immune response mediated by circulating immunoglobulin (ortholog); prevention of polyspe rmy (ortholog); ASSOCIATED WITH Oocyte/Zygote/Embryo Maturation Arrest 6 (ortholog); FOUND IN egg coat (ortholog); endoplasmic reticulum (ortholog); extracellular matrix (ortholog) | NW_004955493 | 400868 | 412660 | Chinchilla | 21 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 11809452 | ZP2 | zona pellucida glycoprotein 2 | ENCODES a protein that exhibits acrosin binding (inferred); identical protein binding (inferred); structural constituent of egg coat (inferred); INVOLVED IN binding of sperm to zona pellucida (ortholog); humoral immune response mediated by circulating immunoglobulin (ortholog); regulation of acrosom e reaction (ortholog); ASSOCIATED WITH Oocyte/Zygote/Embryo Maturation Arrest 6 (ortholog); FOUND IN inclusion body (ortholog) | 16 | 17193632 | 17210667 | Bonobo | 29 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12088306 | ZP2 | zona pellucida glycoprotein 2 | ENCODES a protein that exhibits structural constituent of egg coat (ortholog); INVOLVED IN humoral immune response mediated by circulating immunoglobulin; binding of sperm to zona pellucida (ortholog); prevention of polyspermy (ortholog); ASSOCIATED WITH Oocyte/Zygote/Embryo Maturation Arrest 6 (ort holog); FOUND IN inclusion body; egg coat (ortholog); endoplasmic reticulum (ortholog) | 6 | 24230202 | 24242441 | Dog | 36 | symbol , old_gene_name | gene, protein-coding, VALIDATED [RefSeq] |
| 12700798 | Zp2 | zona pellucida glycoprotein 2 | ENCODES a protein that exhibits acrosin binding (inferred); identical protein binding (inferred); structural constituent of egg coat (inferred); INVOLVED IN binding of sperm to zona pellucida (ortholog); humoral immune response mediated by circulating immunoglobulin (ortholog); regulation of acrosom e reaction (ortholog); ASSOCIATED WITH Oocyte/Zygote/Embryo Maturation Arrest 6 (ortholog); FOUND IN inclusion body (ortholog) | NW_004936501 | 6394838 | 6407512 | Squirrel | 28 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 625848261 | Zp2 | zona pellucida glycoprotein 2 | ENCODES a protein that exhibits acrosin binding (ortholog); identical protein binding (ortholog); structural constituent of egg coat (ortholog); INVOLVED IN binding of sperm to zona pellucida (ortholog); humoral immune response mediated by circulating immunoglobulin (ortholog); prevention of polyspe rmy (ortholog); ASSOCIATED WITH Oocyte/Zygote/Embryo Maturation Arrest 6 (ortholog); FOUND IN egg coat (ortholog); endoplasmic reticulum (ortholog); extracellular matrix (ortholog) | | | | Black Rat | 21 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18348350 | ZP2 | zona pellucida glycoprotein 2 | ENCODES a protein that exhibits acrosin binding (inferred); identical protein binding (inferred); structural constituent of egg coat (inferred); INVOLVED IN binding of sperm to zona pellucida (ortholog); humoral immune response mediated by circulating immunoglobulin (ortholog); regulation of acrosom e reaction (ortholog); ASSOCIATED WITH Oocyte/Zygote/Embryo Maturation Arrest 6 (ortholog); FOUND IN inclusion body (ortholog) | | | | Green Monkey | 29 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 155233603 | zp2 | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 14163949 | ZP2 | zona pellucida glycoprotein 2 | ENCODES a protein that exhibits structural constituent of egg coat (ortholog); INVOLVED IN binding of sperm to zona pellucida (ortholog); humoral immune response mediated by circulating immunoglobulin (ortholog); prevention of polyspermy (ortholog); ASSOCIATED WITH Oocyte/Zygote/Embryo Maturation Ar rest 6 (ortholog); FOUND IN egg coat (ortholog); endoplasmic reticulum (ortholog); extracellular matrix (ortholog) | | | | Pig | 36 | symbol , old_gene_name | gene, protein-coding, PROVISIONAL [RefSeq] |
| 18919439 | Zp2 | zona pellucida glycoprotein 2 | ENCODES a protein that exhibits identical protein binding (ortholog); INVOLVED IN binding of sperm to zona pellucida (ortholog); humoral immune response mediated by circulating immunoglobulin (ortholog); regulation of acrosome reaction (ortholog); ASSOCIATED WITH Oocyte/Zygote/Embryo Maturation Arre st 6 (ortholog); FOUND IN endoplasmic reticulum (ortholog); extracellular matrix (ortholog); inclusion body (ortholog) | | | | Naked Mole-Rat | 23 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 155233604 | zp2.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 16563657 | AF001550.1 | novel transcript, antisense to ZP2 | | | | | Human | | name | gene, lncrna |
| 1349169 | ASTL | astacin like metalloendopeptidase | Predicted to enable aspartic-type peptidase activity; glutamic-type peptidase activity; and metalloendopeptidase activity. Predicted to be involved in several processes, including negative regulation of binding activity of sperm to zona pellucida; positive regulation of protein processing; and preve ntion of polyspermy. Predicted to be located in cortical granule and plasma membrane. [provided by Alliance of Genome Resources, Jul 2025] | 2 | 96122818 | 96138564 | Human | 76 | old_gene_name | gene, protein-coding, VALIDATED [RefSeq] |