Predicted to enable several functions, including RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; nuclear estrogen receptor binding activity; and transcription corepressor activity. Predicted to be involved in negative regulation of intracellular estrogen receptor sign
aling pathway; negative regulation of transcription by RNA polymerase II; and response to estrogen. Located in nucleus. Used to study DiGeorge syndrome. Orthologous to human ZNF366 (zinc finger protein 366). [provided by Alliance of Genome Resources, Jul 2025]
ENCODES a protein that exhibits nuclear estrogen receptor binding (ortholog); transcription corepressor activity (ortholog); INVOLVED IN negative regulation of intracellular estrogen receptor signaling pathway (ortholog); negative regulation of transcription by RNA polymerase II (ortholog); response
to estrogen (ortholog); ASSOCIATED WITH Breast Neoplasms (ortholog); COVID-19 (ortholog); DiGeorge syndrome (ortholog); FOUND IN nucleoplasm (ortholog); nucleus (ortholog); INTERACTS WITH Monobutylphthalate; N,N-diethyl-m-toluamide; permethrin