| 1351632 | ZBTB20 | zinc finger and BTB domain containing 20 | This gene, which was initially designated as dendritic cell-derived BTB/POZ zinc finger (DPZF), belongs to a family of transcription factors with an N-terminal BTB/POZ domain and a C-terminal DNA-bindng zinc finger domain. The BTB/POZ domain is a hydrophobic region of approximately 120 aa which medi ates association with other BTB/POZ domain-containing proteins. This gene acts as a transcriptional repressor and plays a role in many processes including neurogenesis, glucose homeostasis, and postnatal growth. Mutations in this gene have been associated with Primrose syndrome as well as the 3q13.31 microdeletion syndrome. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Feb 2017] | 3 | 114314500 | 115147288 | Human | 342 | symbol , COSMIC , Human Proteome Map | gene, protein-coding, REVIEWED [RefSeq] |
| 1557085 | Zbtb20 | zinc finger and BTB domain containing 20 | Enables DNA-binding transcription repressor activity, RNA polymerase II-specific and transcription cis-regulatory region binding activity. Involved in several processes, including cellular response to glucose stimulus; positive regulation of metabolic process; and regulation of gene expression. Acts upstream of or within negative regulation of transcription by RNA polymerase II. Located in cytoplasm and nucleus. Is expressed in several structures, including alimentary system; cardiovascular system; genitourinary system; nervous system; and sensory organ. Used to study Alzheimer's disease. Orthologous to human ZBTB20 (zinc finger and BTB domain containing 20). [provided by Alliance of Genome Resources, Jul 2025] | 16 | 42728008 | 43462981 | Mouse | 278 | symbol , PhenoGen , description | gene, protein-coding, VALIDATED [RefSeq] |
| 1560387 | Zbtb20 | zinc finger and BTB domain containing 20 | ENCODES a protein that exhibits DNA binding (ortholog); DNA-binding transcription repressor activity, RNA polymerase II-specific (ortholog); sequence-specific double-stranded DNA binding (ortholog); INVOLVED IN cellular response to glucose stimulus (ortholog); lipid homeostasis (ortholog); negative regulation of DNA-templated transcription (ortholog); ASSOCIATED WITH autism spectrum disorder (ortholog); autistic disorder (ortholog); COVID-19 (ortholog); FOUND IN cytoplasm (ortholog); nuclear body (ortholog); nucleoplasm (ortholog); INTERACTS WITH 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine; 2,6-dinitrotoluene | 11 | 70558010 | 71297039 | Rat | 207 | symbol , old_gene_name , PhenoGen | gene, protein-coding, VALIDATED [RefSeq] |
| 9007016 | Zbtb20 | zinc finger and BTB domain containing 20 | ENCODES a protein that exhibits DNA binding (ortholog); DNA-binding transcription repressor activity, RNA polymerase II-specific (ortholog); sequence-specific double-stranded DNA binding (ortholog); INVOLVED IN cellular response to glucose stimulus (ortholog); lipid homeostasis (ortholog); negative regulation of DNA-templated transcription (ortholog); ASSOCIATED WITH autism spectrum disorder (ortholog); autistic disorder (ortholog); COVID-19 (ortholog); FOUND IN cytoplasm (ortholog); nuclear body (ortholog); nucleoplasm (ortholog) | NW_004955427 | 14409700 | 15231495 | Chinchilla | 30 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 11847633 | ZBTB20 | zinc finger and BTB domain containing 20 | ENCODES a protein that exhibits DNA binding (inferred); DNA-binding transcription factor activity, RNA polymerase II-specific (inferred); DNA-binding transcription repressor activity, RNA polymerase II-specific (inferred); INVOLVED IN negative regulation of transcription by RNA polymerase II (orthol og); ASSOCIATED WITH autism spectrum disorder (ortholog); autistic disorder (ortholog); COVID-19 (ortholog); FOUND IN cytoplasm (inferred); nuclear body (inferred); nucleoplasm (inferred) | 3 | 111445520 | 112275946 | Bonobo | 41 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12214422 | ZBTB20 | zinc finger and BTB domain containing 20 | ENCODES a protein that exhibits DNA binding (inferred); DNA-binding transcription repressor activity, RNA polymerase II-specific (inferred); metal ion binding (inferred); INVOLVED IN negative regulation of transcription by RNA polymerase II (ortholog); ASSOCIATED WITH autism spectrum disorder (ortho log); autistic disorder (ortholog); COVID-19 (ortholog); FOUND IN cytoplasm (inferred); nuclear body (inferred); nucleoplasm (inferred) | 33 | 18860824 | 19277691 | Dog | 44 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12599328 | Zbtb20 | zinc finger and BTB domain containing 20 | ENCODES a protein that exhibits DNA binding (inferred); DNA-binding transcription factor activity, RNA polymerase II-specific (inferred); DNA-binding transcription repressor activity, RNA polymerase II-specific (inferred); INVOLVED IN negative regulation of transcription by RNA polymerase II (orthol og); ASSOCIATED WITH autism spectrum disorder (ortholog); autistic disorder (ortholog); COVID-19 (ortholog); FOUND IN cytoplasm (inferred); nuclear body (inferred); nucleoplasm (inferred) | NW_004936536 | 1776065 | 2546286 | Squirrel | 41 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 625875518 | Zbtb20 | zinc finger and BTB domain containing 20 | ENCODES a protein that exhibits DNA binding (ortholog); DNA-binding transcription repressor activity, RNA polymerase II-specific (ortholog); sequence-specific double-stranded DNA binding (ortholog); INVOLVED IN cellular response to glucose stimulus (ortholog); lipid homeostasis (ortholog); negative regulation of DNA-templated transcription (ortholog); ASSOCIATED WITH autism spectrum disorder (ortholog); autistic disorder (ortholog); COVID-19 (ortholog); FOUND IN cytoplasm (ortholog); nuclear body (ortholog); nucleoplasm (ortholog) | | | | Black Rat | 30 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18905959 | Zbtb20 | zinc finger and BTB domain containing 20 | ENCODES a protein that exhibits DNA binding (inferred); DNA-binding transcription factor activity, RNA polymerase II-specific (inferred); DNA-binding transcription repressor activity, RNA polymerase II-specific (inferred); INVOLVED IN negative regulation of transcription by RNA polymerase II (orthol og); ASSOCIATED WITH autism spectrum disorder (ortholog); autistic disorder (ortholog); COVID-19 (ortholog); FOUND IN cytoplasm (inferred); nuclear body (inferred); nucleoplasm (inferred) | | | | Naked Mole-Rat | 41 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 284315838 | zbtb20 | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 13852216 | ZBTB20 | zinc finger and BTB domain containing 20 | ENCODES a protein that exhibits DNA binding (inferred); DNA-binding transcription repressor activity, RNA polymerase II-specific (inferred); metal ion binding (inferred); INVOLVED IN negative regulation of transcription by RNA polymerase II (ortholog); ASSOCIATED WITH autism spectrum disorder (ortho log); autistic disorder (ortholog); COVID-19 (ortholog); FOUND IN cytoplasm (inferred); nuclear body (inferred); nucleoplasm (inferred) | | | | Pig | 44 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18748317 | ZBTB20 | zinc finger and BTB domain containing 20 | ENCODES a protein that exhibits DNA binding (inferred); DNA-binding transcription factor activity, RNA polymerase II-specific (inferred); DNA-binding transcription repressor activity, RNA polymerase II-specific (inferred); INVOLVED IN negative regulation of transcription by RNA polymerase II (orthol og); ASSOCIATED WITH autism spectrum disorder (ortholog); autistic disorder (ortholog); COVID-19 (ortholog); FOUND IN cytoplasm (inferred); nuclear body (inferred); nucleoplasm (inferred) | | | | Green Monkey | 41 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 288083261 | zbtb20.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 288083399 | zbtb20.S | | | | | | African Clawed Frog | | symbol | gene, null |
| 5144405 | ZBTB20-AS1 | ZBTB20 antisense RNA 1 | | 3 | 114351811 | 114388978 | Human | 1 | symbol , COSMIC , name , Human Proteome Map | gene, ncrna, VALIDATED [RefSeq] |
| 5144697 | ZBTB20-AS2 | ZBTB20 antisense RNA 2 | INTERACTS WITH sodium arsenite | | | | Human | 1 | symbol , COSMIC , name , Human Proteome Map | gene, ncrna |
| 9588968 | ZBTB20-AS3 | ZBTB20 antisense RNA 3 | | 3 | 114873033 | 114876514 | Human | | symbol , COSMIC , name , Human Proteome Map | gene, ncrna, VALIDATED [RefSeq] |
| 6481224 | ZBTB20-AS4 | ZBTB20 antisense RNA 4 | INTERACTS WITH 2-hydroxypropanoic acid; okadaic acid; rac-lactic acid | 3 | 115100423 | 115103061 | Human | 3 | symbol , COSMIC , name , Human Proteome Map | gene, ncrna, VALIDATED [RefSeq] |
| 11571533 | ZBTB20-AS5 | ZBTB20 antisense RNA 5 | | 3 | 114453593 | 114520132 | Human | | symbol , COSMIC , name , Human Proteome Map | gene, ncrna, VALIDATED [RefSeq] |
| 11561972 | Zbtb20Tn(pb-Bhr7)1Wmukf | zinc finger and BTB domain containing 20;Bhr7 transposon insertion 1, Wmukf | Transposon "Bhr7" was inserted into the Intron 3 of Zbtb20 gene. | | | | Rat | | symbol , description , old_gene_symbol | gene, allele |
| 16555078 | AC236972.1 | zinc finger and BTB domain containing 20 (ZBTB20) pseudogene | | | | | Human | | name | gene, unprocessed_pseudogene |