| 1311696 | Yars2 | tyrosyl-tRNA synthetase 2 | ENCODES a protein that exhibits L-tyrosine binding (ortholog); protein homodimerization activity (ortholog); tRNA binding (ortholog); INVOLVED IN mitochondrial tyrosyl-tRNA aminoacylation (ortholog); tRNA aminoacylation (ortholog); PARTICIPATES IN aminoacyl-tRNA biosynthetic pathway; ASSOCIATED WITH genetic disease (ortholog); mitochondrial metabolism disease (ortholog); myopathy, lactic acidosis, and sideroblastic anemia (ortholog); FOUND IN mitochondrial matrix (ortholog); mitochondrion (ortholog); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,4-dinitrotoluene; 4-amino-2,6-dinitrotoluene | 11 | 98136530 | 98142320 | Rat | 109 | symbol , PhenoGen | gene, protein-coding, PROVISIONAL [RefSeq] |
| 1550943 | Yars2 | tyrosyl-tRNA synthetase 2 (mitochondrial) | Predicted to enable several functions, including L-tyrosine binding activity; protein homodimerization activity; and tyrosine-tRNA ligase activity. Predicted to be involved in mitochondrial tyrosyl-tRNA aminoacylation. Located in mitochondrion. Is expressed in several structures, including alimentar y system; central nervous system; genitourinary system; integumental system; and respiratory system. Human ortholog(s) of this gene implicated in myopathy, lactic acidosis, and sideroblastic anemia 2. Orthologous to human YARS2 (tyrosyl-tRNA synthetase 2). [provided by Alliance of Genome Resources, Jul 2025] | 16 | 16120829 | 16127504 | Mouse | 119 | symbol , PhenoGen , description | gene, protein-coding, VALIDATED [RefSeq] |
| 1606290 | YARS2 | tyrosyl-tRNA synthetase 2 | This gene encodes a mitochondrial protein that catalyzes the attachment of tyrosine to tRNA(Tyr). Mutations in this gene are associated with myopathy with lactic acidosis and sideroblastic anemia type 2 (MLASA2). [provided by RefSeq, Jan 2011] | 12 | 32746544 | 32755897 | Human | 182 | symbol , COSMIC , Human Proteome Map | gene, protein-coding, REVIEWED [RefSeq] |
| 8827916 | Yars2 | tyrosyl-tRNA synthetase 2 | ENCODES a protein that exhibits L-tyrosine binding (ortholog); protein homodimerization activity (ortholog); tRNA binding (ortholog); INVOLVED IN mitochondrial tyrosyl-tRNA aminoacylation (ortholog); tRNA aminoacylation (ortholog); ASSOCIATED WITH genetic disease (ortholog); mitochondrial metabolism disease (ortholog); myopathy, lactic acidosis, and sideroblastic anemia (ortholog); FOUND IN mitochondrial matrix (ortholog); mitochondrion (ortholog) | NW_004955505 | 3004084 | 3011003 | Chinchilla | 15 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 11868480 | YARS2 | tyrosyl-tRNA synthetase 2 | ENCODES a protein that exhibits aminoacyl-tRNA ligase activity (inferred); ATP binding (inferred); L-tyrosine binding (inferred); INVOLVED IN mitochondrial tyrosyl-tRNA aminoacylation (inferred); translation (inferred); tRNA aminoacylation (inferred); ASSOCIATED WITH genetic disease (ortholog); mito chondrial metabolism disease (ortholog); myopathy, lactic acidosis, and sideroblastic anemia (ortholog); FOUND IN cytosol (inferred); mitochondrial matrix (inferred); mitochondrion (inferred) | 12 | 53463086 | 53493352 | Bonobo | 33 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12355674 | YARS2 | tyrosyl-tRNA synthetase 2 | ENCODES a protein that exhibits L-tyrosine binding (ortholog); protein homodimerization activity (ortholog); tRNA binding (ortholog); INVOLVED IN mitochondrial tyrosyl-tRNA aminoacylation (ortholog); ASSOCIATED WITH genetic disease (ortholog); mitochondrial metabolism disease (ortholog); myopathy, l actic acidosis, and sideroblastic anemia (ortholog); FOUND IN mitochondrion (ortholog) | 27 | 16139462 | 16162701 | Dog | 31 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12493259 | Yars2 | tyrosyl-tRNA synthetase 2 | ENCODES a protein that exhibits aminoacyl-tRNA ligase activity (inferred); ATP binding (inferred); L-tyrosine binding (inferred); INVOLVED IN mitochondrial tyrosyl-tRNA aminoacylation (inferred); translation (inferred); tRNA aminoacylation (inferred); ASSOCIATED WITH genetic disease (ortholog); mito chondrial metabolism disease (ortholog); myopathy, lactic acidosis, and sideroblastic anemia (ortholog); FOUND IN cytosol (inferred); mitochondrial matrix (inferred); mitochondrion (inferred) | NW_004936607 | 3565333 | 3590499 | Squirrel | 33 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 13955038 | YARS2 | tyrosyl-tRNA synthetase 2 | ENCODES a protein that exhibits aminoacyl-tRNA ligase activity (inferred); ATP binding (inferred); L-tyrosine binding (inferred); INVOLVED IN mitochondrial tyrosyl-tRNA aminoacylation (inferred); translation (inferred); tRNA aminoacylation (inferred); ASSOCIATED WITH genetic disease (ortholog); mito chondrial metabolism disease (ortholog); myopathy, lactic acidosis, and sideroblastic anemia (ortholog); FOUND IN mitochondrial matrix (inferred); mitochondrion (inferred); INTERACTS WITH deoxynivalenol | | | | Pig | 34 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18562117 | YARS2 | tyrosyl-tRNA synthetase 2 | ENCODES a protein that exhibits aminoacyl-tRNA ligase activity (inferred); ATP binding (inferred); L-tyrosine binding (inferred); INVOLVED IN mitochondrial tyrosyl-tRNA aminoacylation (inferred); translation (inferred); tRNA aminoacylation (inferred); ASSOCIATED WITH genetic disease (ortholog); mito chondrial metabolism disease (ortholog); myopathy, lactic acidosis, and sideroblastic anemia (ortholog); FOUND IN cytosol (inferred); mitochondrial matrix (inferred); mitochondrion (inferred) | | | | Green Monkey | 33 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18929470 | Yars2 | tyrosyl-tRNA synthetase 2 | ENCODES a protein that exhibits L-tyrosine binding (ortholog); protein homodimerization activity (ortholog); tRNA binding (ortholog); INVOLVED IN mitochondrial tyrosyl-tRNA aminoacylation (ortholog); ASSOCIATED WITH genetic disease (ortholog); mitochondrial metabolism disease (ortholog); myopathy, l actic acidosis, and sideroblastic anemia (ortholog); FOUND IN cytosol (inferred); mitochondrial matrix (inferred); mitochondrion (inferred) | | | | Naked Mole-Rat | 30 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 155257759 | yars2 | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 625954579 | Yars2 | tyrosyl-tRNA synthetase 2 | ENCODES a protein that exhibits L-tyrosine binding (ortholog); protein homodimerization activity (ortholog); tRNA binding (ortholog); INVOLVED IN mitochondrial tyrosyl-tRNA aminoacylation (ortholog); tRNA aminoacylation (ortholog); ASSOCIATED WITH genetic disease (ortholog); mitochondrial metabolism disease (ortholog); myopathy, lactic acidosis, and sideroblastic anemia (ortholog); FOUND IN mitochondrial matrix (ortholog); mitochondrion (ortholog) | | | | Black Rat | 15 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 626186963 | yars2.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 16572046 | AC087588.2 | novel transcript, antisense to YARS2 | | | | | Human | | name | gene, lncrna |
| 16567096 | AC084824.3 | novel transcript, sense intronic to YARS2 | | | | | Human | | name | gene, lncrna |
| 16567692 | AC084824.4 | novel transcript, sense intronic to YARS2 | | | | | Human | | name | gene, lncrna |