| 620644 | Vps33b | VPS33B, late endosome and lysosome associated | ENCODES a protein that exhibits protein-containing complex binding (ortholog); INVOLVED IN autophagosome maturation (ortholog); collagen fibril organization (ortholog); collagen metabolic process (ortholog); ASSOCIATED WITH ARC syndrome (ortholog); arthrogryposis multiplex congenita (ortholog); arth rogryposis, renal dysfunction, and cholestasis 1 (ortholog); FOUND IN synaptic vesicle; clathrin-coated vesicle (ortholog); cytoplasm (ortholog); INTERACTS WITH 1,2,4-trimethylbenzene; 2,4-dinitrotoluene; 2,6-dinitrotoluene | 1 | 143633167 | 143656228 | Rat | 133 | symbol , old_gene_name , PhenoGen , name | gene, protein-coding, PROVISIONAL [RefSeq] |
| 732726 | VPS33B | VPS33B late endosome and lysosome associated | Vesicle mediated protein sorting plays an important role in segregation of intracellular molecules into distinct organelles. Genetic studies in yeast have identified more than 40 vacuolar protein sorting (VPS) genes involved in vesicle transport to vacuoles. This gene is a member of the Sec-1 domain family, and encodes the human ortholog of rat Vps33b which is homologous to the yeast class C Vps33 protein. The mammalian class C vacuolar protein sorting proteins are predominantly associated with late endosomes/lysosomes, and like their yeast counterparts, may mediate vesicle trafficking steps in the endosome/lysosome pathway. Mutations in this gene are associated with arthrogryposis-renal dysfunction-cholestasis syndrome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014] | 15 | 90998416 | 91022621 | Human | 254 | symbol , old_gene_name , COSMIC , name , description , Human Proteome Map | gene, protein-coding, REVIEWED [RefSeq] |
| 737437 | Vps33b | vacuolar protein sorting 33B | Involved in megakaryocyte development; platelet alpha granule organization; and regulation of platelet aggregation. Acts upstream of or within several processes, including collagen fibril organization; collagen metabolic process; and peptidyl-lysine hydroxylation. Predicted to be located in Golgi ap paratus; cytoplasmic vesicle; and perinuclear region of cytoplasm. Predicted to be part of CORVET complex and HOPS complex. Predicted to be active in lysosome and synaptic vesicle. Is expressed in dorsal root ganglion; facial ganglion; glossopharyngeal ganglion; trigeminal ganglion; and vestibulo-cochlear ganglion. Used to study ARC syndrome. Human ortholog(s) of this gene implicated in arthrogryposis multiplex congenita; arthrogryposis, renal dysfunction, and cholestasis 1; cholestasis; kidney disease; and progressive familial intrahepatic cholestasis. Orthologous to human VPS33B (VPS33B late endosome and lysosome associated). [provided by Alliance of Genome Resources, Jul 2025] | 7 | 79919369 | 79941323 | Mouse | 174 | symbol , PhenoGen , description | gene, protein-coding, VALIDATED [RefSeq] |
| 8936447 | Vps33b | VPS33B late endosome and lysosome associated | ENCODES a protein that exhibits protein-containing complex binding (ortholog); INVOLVED IN autophagosome maturation (ortholog); collagen fibril organization (ortholog); collagen metabolic process (ortholog); ASSOCIATED WITH ARC syndrome (ortholog); arthrogryposis multiplex congenita (ortholog); arth rogryposis, renal dysfunction, and cholestasis 1 (ortholog); FOUND IN clathrin-coated vesicle (ortholog); cytoplasm (ortholog); early endosome membrane (ortholog) | NW_004955416 | 15049849 | 15071108 | Chinchilla | 55 | symbol , old_gene_name , name | gene, protein-coding, MODEL [RefSeq] |
| 11927925 | VPS33B | VPS33B late endosome and lysosome associated | ENCODES a protein that exhibits protein-containing complex binding (inferred); INVOLVED IN autophagosome maturation (ortholog); collagen fibril organization (ortholog); collagen metabolic process (ortholog); ASSOCIATED WITH ARC syndrome (ortholog); arthrogryposis multiplex congenita (ortholog); arth rogryposis, renal dysfunction, and cholestasis 1 (ortholog); FOUND IN HOPS complex (ortholog); synaptic vesicle (ortholog) | 15 | 69691717 | 69715617 | Bonobo | 62 | symbol , old_gene_name , name | gene, protein-coding, MODEL [RefSeq] |
| 12192158 | VPS33B | VPS33B late endosome and lysosome associated | ENCODES a protein that exhibits protein-containing complex binding (ortholog); INVOLVED IN autophagosome maturation (ortholog); collagen fibril organization (ortholog); collagen metabolic process (ortholog); ASSOCIATED WITH ARC syndrome (ortholog); arthrogryposis multiplex congenita (ortholog); arth rogryposis, renal dysfunction, and cholestasis 1 (ortholog); FOUND IN cytoplasm (ortholog); early endosome membrane (ortholog); endosome (ortholog); INTERACTS WITH mocetinostat | 3 | 53220199 | 53239738 | Dog | 65 | symbol , old_gene_name , name | gene, protein-coding, MODEL [RefSeq] |
| 12732467 | Vps33b | VPS33B late endosome and lysosome associated | ENCODES a protein that exhibits protein-containing complex binding (inferred); INVOLVED IN autophagosome maturation (ortholog); collagen fibril organization (ortholog); collagen metabolic process (ortholog); ASSOCIATED WITH ARC syndrome (ortholog); arthrogryposis multiplex congenita (ortholog); arth rogryposis, renal dysfunction, and cholestasis 1 (ortholog); FOUND IN HOPS complex (ortholog); synaptic vesicle (ortholog) | NW_004936483 | 16007448 | 16031353 | Squirrel | 62 | symbol , old_gene_name , name | gene, protein-coding, MODEL [RefSeq] |
| 155234616 | vps33b | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 14389160 | Vps33B | | | | | | Fly | | symbol | gene, null |
| 18550638 | VPS33B | VPS33B late endosome and lysosome associated | ENCODES a protein that exhibits protein-containing complex binding (inferred); INVOLVED IN autophagosome maturation (ortholog); collagen fibril organization (ortholog); collagen metabolic process (ortholog); ASSOCIATED WITH ARC syndrome (ortholog); arthrogryposis multiplex congenita (ortholog); arth rogryposis, renal dysfunction, and cholestasis 1 (ortholog); FOUND IN HOPS complex (ortholog); synaptic vesicle (ortholog) | | | | Green Monkey | 62 | symbol , name | gene, protein-coding, MODEL [RefSeq] |
| 626028478 | Vps33b | VPS33B late endosome and lysosome associated | ENCODES a protein that exhibits protein-containing complex binding (ortholog); INVOLVED IN autophagosome maturation (ortholog); collagen fibril organization (ortholog); collagen metabolic process (ortholog); ASSOCIATED WITH ARC syndrome (ortholog); arthrogryposis multiplex congenita (ortholog); arth rogryposis, renal dysfunction, and cholestasis 1 (ortholog); FOUND IN clathrin-coated vesicle (ortholog); cytoplasm (ortholog); early endosome membrane (ortholog) | | | | Black Rat | 55 | symbol , name | gene, protein-coding, MODEL [RefSeq] |
| 14001866 | VPS33B | VPS33B late endosome and lysosome associated | ENCODES a protein that exhibits protein-containing complex binding (inferred); INVOLVED IN autophagosome maturation (ortholog); collagen fibril organization (ortholog); collagen metabolic process (ortholog); ASSOCIATED WITH ARC syndrome (ortholog); arthrogryposis multiplex congenita (ortholog); arth rogryposis, renal dysfunction, and cholestasis 1 (ortholog); FOUND IN HOPS complex (ortholog); synaptic vesicle (ortholog) | | | | Pig | 66 | symbol , name | gene, protein-coding, MODEL [RefSeq] |
| 18935683 | Vps33b | VPS33B late endosome and lysosome associated | ENCODES a protein that exhibits protein-containing complex binding (ortholog); INVOLVED IN autophagosome maturation (ortholog); collagen fibril organization (ortholog); collagen metabolic process (ortholog); ASSOCIATED WITH ARC syndrome (ortholog); arthrogryposis multiplex congenita (ortholog); arth rogryposis, renal dysfunction, and cholestasis 1 (ortholog); FOUND IN cytoplasm (ortholog); early endosome membrane (ortholog); endosome (ortholog) | | | | Naked Mole-Rat | 66 | symbol , name | gene, protein-coding, MODEL [RefSeq] |
| 155243582 | vps33b.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 13208396 | VPS33B-DT | VPS33B divergent transcript | INTERACTS WITH acrylamide; aristolochic acid A; bisphenol A | 15 | 91022622 | 91031139 | Human | 3 | symbol , COSMIC , name , Human Proteome Map | gene, ncrna, VALIDATED [RefSeq] |
| 16558725 | AL445187.1 | vacuolar protein sorting 33B (VPS33B) pseudogene | | | | | Human | | name | gene, unprocessed_pseudogene |
| 1351893 | VIPAS39 | VPS33B interacting protein, apical-basolateral polarity regulator, spe-39 homolog | Involved in endosome to lysosome transport and intracellular protein transport. Acts upstream of or within collagen metabolic process and peptidyl-lysine hydroxylation. Located in Golgi apparatus and endosome. Part of vesicle tethering complex. Implicated in arthrogryposis, renal dysfunction, and ch olestasis 2. [provided by Alliance of Genome Resources, Jul 2025] | 14 | 77426675 | 77457601 | Human | 142 | old_gene_name , name | gene, protein-coding, REVIEWED [RefSeq] |
| 1589291 | Vipas39 | VPS33B interacting protein, apical-basolateral polarity regulator, spe-39 homolog | ENCODES a protein that exhibits protein-containing complex binding (ortholog); INVOLVED IN autophagosome maturation (ortholog); collagen fibril organization (ortholog); collagen metabolic process (ortholog); ASSOCIATED WITH ARC syndrome (ortholog); arthrogryposis, renal dysfunction, and cholestasis 1 (ortholog); arthrogryposis, renal dysfunction, and cholestasis 2 (ortholog); FOUND IN cytoplasm (ortholog); early endosome (ortholog); endosome (ortholog); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; bisphenol A; endosulfan | 6 | 112619228 | 112644089 | Rat | 83 | old_gene_name , name | gene, protein-coding, VALIDATED [RefSeq] |
| 1618250 | Vipas39 | VPS33B interacting protein, apical-basolateral polarity regulator, spe-39 homolog | Acts upstream of or within several processes, including collagen fibril organization; collagen metabolic process; and protein modification process. Predicted to be located in Golgi apparatus and endosome. Predicted to be part of vesicle tethering complex. Predicted to be active in cytoplasm. Is expr essed in several structures, including central nervous system; retina layer; and skeletal muscle. Used to study ARC syndrome. Human ortholog(s) of this gene implicated in arthrogryposis, renal dysfunction, and cholestasis 2. Orthologous to human VIPAS39 (VPS33B interacting protein, apical-basolateral polarity regulator, spe-39 homolog). [provided by Alliance of Genome Resources, Apr 2025] | 12 | 87285647 | 87313426 | Mouse | 91 | old_gene_name , name , description | gene, protein-coding, VALIDATED [RefSeq] |
| 8875708 | Vipas39 | VPS33B interacting protein, apical-basolateral polarity regulator, spe-39 homolog | ENCODES a protein that exhibits protein-containing complex binding (ortholog); INVOLVED IN autophagosome maturation (ortholog); collagen fibril organization (ortholog); collagen metabolic process (ortholog); ASSOCIATED WITH ARC syndrome (ortholog); arthrogryposis, renal dysfunction, and cholestasis 1 (ortholog); arthrogryposis, renal dysfunction, and cholestasis 2 (ortholog); FOUND IN cytoplasm (ortholog); early endosome (ortholog); endosome (ortholog) | NW_004955438 | 1320862 | 1351344 | Chinchilla | 27 | name | gene, protein-coding, MODEL [RefSeq] |
| 11938742 | VIPAS39 | VPS33B interacting protein, apical-basolateral polarity regulator, spe-39 homolog | ENCODES a protein that exhibits protein-containing complex binding (inferred); INVOLVED IN autophagosome maturation (ortholog); collagen fibril organization (ortholog); collagen metabolic process (ortholog); ASSOCIATED WITH ARC syndrome (ortholog); arthrogryposis, renal dysfunction, and cholestasis 1 (ortholog); arthrogryposis, renal dysfunction, and cholestasis 2 (ortholog); FOUND IN HOPS complex (ortholog) | 14 | 57982041 | 58013037 | Bonobo | 38 | name | gene, protein-coding, MODEL [RefSeq] |
| 12123384 | VIPAS39 | VPS33B interacting protein, apical-basolateral polarity regulator, spe-39 homolog | ENCODES a protein that exhibits protein-containing complex binding (inferred); INVOLVED IN autophagosome maturation (ortholog); collagen fibril organization (ortholog); collagen metabolic process (ortholog); ASSOCIATED WITH ARC syndrome (ortholog); arthrogryposis, renal dysfunction, and cholestasis 1 (ortholog); arthrogryposis, renal dysfunction, and cholestasis 2 (ortholog); FOUND IN HOPS complex (ortholog) | 8 | 50233162 | 50258030 | Dog | 38 | name | gene, protein-coding, MODEL [RefSeq] |
| 12517657 | Vipas39 | VPS33B interacting protein, apical-basolateral polarity regulator, spe-39 homolog | ENCODES a protein that exhibits protein-containing complex binding (inferred); INVOLVED IN autophagosome maturation (ortholog); collagen fibril organization (ortholog); collagen metabolic process (ortholog); ASSOCIATED WITH ARC syndrome (ortholog); arthrogryposis, renal dysfunction, and cholestasis 1 (ortholog); arthrogryposis, renal dysfunction, and cholestasis 2 (ortholog); FOUND IN HOPS complex (ortholog) | NW_004936488 | 6247329 | 6277494 | Squirrel | 36 | name | gene, protein-coding, MODEL [RefSeq] |
| 13993857 | VIPAS39 | VPS33B interacting protein, apical-basolateral polarity regulator, spe-39 homolog | ENCODES a protein that exhibits protein-containing complex binding (inferred); INVOLVED IN autophagosome maturation (ortholog); collagen fibril organization (ortholog); collagen metabolic process (ortholog); ASSOCIATED WITH ARC syndrome (ortholog); arthrogryposis, renal dysfunction, and cholestasis 1 (ortholog); arthrogryposis, renal dysfunction, and cholestasis 2 (ortholog); FOUND IN HOPS complex (ortholog) | | | | Pig | 38 | name | gene, protein-coding, MODEL [RefSeq] |
| 18906684 | Vipas39 | VPS33B interacting protein, apical-basolateral polarity regulator, spe-39 homolog | ENCODES a protein that exhibits protein-containing complex binding (ortholog); INVOLVED IN autophagosome maturation (ortholog); collagen fibril organization (ortholog); collagen metabolic process (ortholog); ASSOCIATED WITH ARC syndrome (ortholog); arthrogryposis, renal dysfunction, and cholestasis 1 (ortholog); arthrogryposis, renal dysfunction, and cholestasis 2 (ortholog); FOUND IN endosome (ortholog); Golgi apparatus (ortholog); HOPS complex (ortholog) | | | | Naked Mole-Rat | 32 | name | gene, protein-coding, MODEL [RefSeq] |
| 625992285 | Vipas39 | VPS33B interacting protein, apical-basolateral polarity regulator, spe-39 homolog | ENCODES a protein that exhibits protein-containing complex binding (ortholog); INVOLVED IN autophagosome maturation (ortholog); collagen fibril organization (ortholog); collagen metabolic process (ortholog); ASSOCIATED WITH ARC syndrome (ortholog); arthrogryposis, renal dysfunction, and cholestasis 1 (ortholog); arthrogryposis, renal dysfunction, and cholestasis 2 (ortholog); FOUND IN cytoplasm (ortholog); early endosome (ortholog); endosome (ortholog) | | | | Black Rat | 27 | name | gene, protein-coding, MODEL [RefSeq] |
| 18486547 | VIPAS39 | VPS33B interacting protein, apical-basolateral polarity regulator, spe-39 homolog | ENCODES a protein that exhibits protein-containing complex binding (inferred); INVOLVED IN autophagosome maturation (ortholog); collagen fibril organization (ortholog); collagen metabolic process (ortholog); ASSOCIATED WITH ARC syndrome (ortholog); arthrogryposis, renal dysfunction, and cholestasis 1 (ortholog); arthrogryposis, renal dysfunction, and cholestasis 2 (ortholog); FOUND IN HOPS complex (ortholog) | | | | Green Monkey | 38 | name | gene, protein-coding, MODEL [RefSeq] |