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Gene: VPS33B (VPS33B late endosome and lysosome associated) Homo sapiens
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Symbol: VPS33B
Name: VPS33B late endosome and lysosome associated
Description: Vesicle mediated protein sorting plays an important role in segregation of intracellular molecules into distinct organelles. Genetic studies in yeast have identified more than 40 vacuolar protein sorting (VPS) genes involved in vesicle transport to vacuoles. This gene is a member of the Sec-1 domain family, and encodes the human ortholog of rat Vps33b which is homologous to the yeast class C Vps33 protein. The mammalian class C vacuolar protein sorting proteins are predominantly associated with late endosomes/lysosomes, and like their yeast counterparts, may mediate vesicle trafficking steps in the endosome/lysosome pathway. Mutations in this gene are associated with arthrogryposis-renal dysfunction-cholestasis syndrome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014]
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: FLJ14848; hVPS33B; vacuolar protein sorting 33 homolog B; vacuolar protein sorting 33-like protein B; vacuolar protein sorting 33B; vacuolar protein sorting homolog r-vps33b; vacuolar protein sorting-associated protein 33B; VPS33B, late endosome and lysosome associated
Orthologs:
Mus musculus (house mouse) : Vps33b (vacuolar protein sorting 33B)  MGI  Alliance
Rattus norvegicus (Norway rat) : Vps33b (VPS33B, late endosome and lysosome associated)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Vps33b (VPS33B late endosome and lysosome associated)
Pan paniscus (bonobo/pygmy chimpanzee) : VPS33B (VPS33B late endosome and lysosome associated)
Canis lupus familiaris (dog) : VPS33B (VPS33B late endosome and lysosome associated)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Vps33b (VPS33B late endosome and lysosome associated)
Sus scrofa (pig) : VPS33B (VPS33B late endosome and lysosome associated)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381590,998,416 - 91,022,839 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh371591,541,774 - 91,565,833 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361589,342,778 - 89,366,837 (-)NCBINCBI36hg18NCBI36
Build 341589,342,908 - 89,366,817NCBI
Celera1567,950,993 - 67,975,048 (-)NCBI
Cytogenetic Map15q26.1NCBI
HuRef1567,652,646 - 67,676,700 (-)NCBIHuRef
CHM1_11591,383,216 - 91,407,410 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
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Nomenclature History
 
More on VPS33B
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 732726
Created: 2004-01-12
Species: Homo sapiens
Last Modified: 2019-07-09
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.