| 1306615 | Usp53 | ubiquitin specific peptidase 53 | ENCODES a protein that exhibits cysteine-type deubiquitinase activity (ortholog); K63-linked deubiquitinase activity (ortholog); INVOLVED IN action potential (ortholog); apoptotic process (ortholog); neuron apoptotic process (ortholog); ASSOCIATED WITH cholestasis (ortholog); genetic disease (orthol og); primary ovarian insufficiency (ortholog); FOUND IN bicellular tight junction (ortholog); cell-cell junction (ortholog); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 4,4'-diaminodiphenylmethane; acrylamide | 2 | 213744106 | 213805619 | Rat | 112 | symbol , PhenoGen | gene, protein-coding, VALIDATED [RefSeq] |
| 1315332 | USP53 | ubiquitin specific peptidase 53 | Enables K63-linked deubiquitinase activity. Predicted to be involved in response to auditory stimulus and sensory perception of sound. Predicted to act upstream of or within action potential; epithelial cell apoptotic process; and outer hair cell apoptotic process. Located in bicellular tight juncti on. Implicated in progressive familial intrahepatic cholestasis. [provided by Alliance of Genome Resources, Jul 2025] | 4 | 119212601 | 119295518 | Human | 161 | symbol , COSMIC , Human Proteome Map | gene, protein-coding, VALIDATED [RefSeq] |
| 1550534 | Usp53 | ubiquitin specific peptidase 53 | Predicted to enable K63-linked deubiquitinase activity. Acts upstream of or within several processes, including outer hair cell apoptotic process; response to auditory stimulus; and sensory perception of sound. Located in cell-cell junction. Is expressed in olfactory epithelium; submandibular gland primordium; and tooth. Human ortholog(s) of this gene implicated in progressive familial intrahepatic cholestasis. Orthologous to human USP53 (ubiquitin specific peptidase 53). [provided by Alliance of Genome Resources, Jul 2025] | 3 | 122725142 | 122778184 | Mouse | 142 | symbol , PhenoGen , description | gene, protein-coding, VALIDATED [RefSeq] |
| 9068207 | Usp53 | ubiquitin specific peptidase 53 | ENCODES a protein that exhibits cysteine-type deubiquitinase activity (ortholog); K63-linked deubiquitinase activity (ortholog); INVOLVED IN action potential (ortholog); apoptotic process (ortholog); neuron apoptotic process (ortholog); ASSOCIATED WITH cholestasis (ortholog); genetic disease (orthol og); primary ovarian insufficiency (ortholog); FOUND IN bicellular tight junction (ortholog); cell-cell junction (ortholog) | NW_004955428 | 20957807 | 21023380 | Chinchilla | 19 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 11694234 | USP53 | ubiquitin specific peptidase 53 | ENCODES a protein that exhibits cysteine-type deubiquitinase activity (ortholog); INVOLVED IN action potential (ortholog); apoptotic process (ortholog); neuron apoptotic process (ortholog); ASSOCIATED WITH cholestasis (ortholog); genetic disease (ortholog); primary ovarian insufficiency (ortholog); FOUND IN bicellular tight junction (inferred); cell-cell junction (inferred) | 4 | 111407037 | 111483541 | Bonobo | 27 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12224684 | USP53 | ubiquitin specific peptidase 53 | ENCODES a protein that exhibits cysteine-type deubiquitinase activity (ortholog); INVOLVED IN action potential (ortholog); apoptotic process (ortholog); neuron apoptotic process (ortholog); ASSOCIATED WITH cholestasis (ortholog); genetic disease (ortholog); primary ovarian insufficiency (ortholog); FOUND IN bicellular tight junction (inferred); cell-cell junction (inferred) | 32 | 38148120 | 38213370 | Dog | 25 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12665718 | Usp53 | ubiquitin specific peptidase 53 | ENCODES a protein that exhibits cysteine-type deubiquitinase activity (ortholog); INVOLVED IN action potential (ortholog); apoptotic process (ortholog); neuron apoptotic process (ortholog); ASSOCIATED WITH cholestasis (ortholog); genetic disease (ortholog); primary ovarian insufficiency (ortholog); FOUND IN bicellular tight junction (inferred); cell-cell junction (inferred) | NW_004936869 | 169118 | 226495 | Squirrel | 26 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18373014 | USP53 | ubiquitin specific peptidase 53 | ENCODES a protein that exhibits cysteine-type deubiquitinase activity (ortholog); INVOLVED IN action potential (ortholog); apoptotic process (ortholog); neuron apoptotic process (ortholog); ASSOCIATED WITH cholestasis (ortholog); genetic disease (ortholog); primary ovarian insufficiency (ortholog); FOUND IN bicellular tight junction (inferred); cell-cell junction (inferred) | | | | Green Monkey | 27 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 625873532 | Usp53 | ubiquitin specific peptidase 53 | ENCODES a protein that exhibits cysteine-type deubiquitinase activity (ortholog); K63-linked deubiquitinase activity (ortholog); INVOLVED IN action potential (ortholog); apoptotic process (ortholog); neuron apoptotic process (ortholog); ASSOCIATED WITH cholestasis (ortholog); genetic disease (orthol og); primary ovarian insufficiency (ortholog); FOUND IN bicellular tight junction (ortholog); cell-cell junction (ortholog) | | | | Black Rat | 19 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 14094288 | USP53 | ubiquitin specific peptidase 53 | ENCODES a protein that exhibits cysteine-type deubiquitinase activity (ortholog); INVOLVED IN action potential (ortholog); apoptotic process (ortholog); neuron apoptotic process (ortholog); ASSOCIATED WITH cholestasis (ortholog); genetic disease (ortholog); primary ovarian insufficiency (ortholog); FOUND IN bicellular tight junction (inferred); cell-cell junction (inferred) | | | | Pig | 25 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 155256238 | usp53 | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 155256239 | usp53.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 155256842 | usp53.S | | | | | | African Clawed Frog | | symbol | gene, null |
| 38616286 | USP53-DT | USP53 divergent transcript | | 4 | 119192773 | 119212644 | Human | | symbol , GTEx , COSMIC , name , Human Proteome Map | gene, ncrna, VALIDATED [RefSeq] |
| 18930475 | LOC101723513 | inactive ubiquitin carboxyl-terminal hydrolase 53 | ENCODES a protein that exhibits cysteine-type deubiquitinase activity (inferred); hydrolase activity (inferred); INVOLVED IN response to auditory stimulus (inferred); sensory perception of sound (inferred); FOUND IN cell-cell junction (inferred) | | | | Naked Mole-Rat | 5 | old_gene_symbol | gene, protein-coding, MODEL [RefSeq] |