| 1354275 | USP26 | ubiquitin specific peptidase 26 | This gene encodes a member of the ubiquitin-specific processing (UBP) family of proteases and is a deubiquitinating enzyme (DUB) with His and Cys domains. It is specifically expressed in testis tissue. Mutations in this gene have been associated with Sertoli cell-only syndrome and male infertility. [provided by RefSeq, Jul 2008] | X | 133023168 | 133097109 | Human | 62 | symbol , COSMIC , Human Proteome Map | gene, protein-coding, REVIEWED [RefSeq] |
| 1557856 | Usp26 | ubiquitin specific peptidase 26 | Predicted to enable K48-linked deubiquitinase activity and cysteine-type deubiquitinase activity. Involved in negative regulation of proteasomal ubiquitin-dependent protein catabolic process. Predicted to be located in nucleoplasm and sperm flagellum. Predicted to be active in cytosol and nucleus. I s expressed in testis. Human ortholog(s) of this gene implicated in X-linked spermatogenic failure 6. Orthologous to human USP26 (ubiquitin specific peptidase 26). [provided by Alliance of Genome Resources, Jul 2025] | X | 50841544 | 50890110 | Mouse | 54 | symbol , PhenoGen , description | gene, protein-coding, VALIDATED [RefSeq] |
| 1563443 | Usp26 | ubiquitin specific peptidase 26 | ENCODES a protein that exhibits deubiquitinase activity (ortholog); K48-linked deubiquitinase activity (ortholog); INVOLVED IN negative regulation of proteasomal ubiquitin-dependent protein catabolic process (ortholog); regulation of androgen receptor signaling pathway (ortholog); spermatogenesis (o rtholog); ASSOCIATED WITH Asthenozoospermia (ortholog); male infertility (ortholog); oligospermia (ortholog); FOUND IN nucleoplasm (ortholog); nucleus (ortholog); sperm flagellum (ortholog); INTERACTS WITH bisphenol A; 2,3',4,4',5-Pentachlorobiphenyl (ortholog); 2,3,7,8-tetrachlorodibenzodioxine (ortholog) | X | 136237504 | 136284646 | Rat | 38 | symbol , PhenoGen | gene, protein-coding, VALIDATED [RefSeq] |
| 8837713 | Usp26 | ubiquitin specific peptidase 26 | ENCODES a protein that exhibits deubiquitinase activity (ortholog); K48-linked deubiquitinase activity (ortholog); INVOLVED IN negative regulation of proteasomal ubiquitin-dependent protein catabolic process (ortholog); regulation of androgen receptor signaling pathway (ortholog); spermatogenesis (o rtholog); ASSOCIATED WITH Asthenozoospermia (ortholog); male infertility (ortholog); oligospermia (ortholog); FOUND IN nucleoplasm (ortholog); nucleus (ortholog); sperm flagellum (ortholog) | NW_004955473 | 1903865 | 1957747 | Chinchilla | 18 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 11692692 | USP26 | ubiquitin specific peptidase 26 | ENCODES a protein that exhibits cysteine-type deubiquitinase activity (inferred); cysteine-type peptidase activity (inferred); deubiquitinase activity (inferred); INVOLVED IN G1/S transition of mitotic cell cycle (inferred); negative regulation of proteasomal ubiquitin-dependent protein catabolic pr ocess (inferred); protein deubiquitination (inferred); ASSOCIATED WITH Asthenozoospermia (ortholog); male infertility (ortholog); oligospermia (ortholog); FOUND IN cytoplasm (inferred); cytosol (inferred); nucleoplasm (inferred) | X | 122155933 | 122160000 | Bonobo | 31 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12211200 | USP26 | ubiquitin specific peptidase 26 | ENCODES a protein that exhibits deubiquitinase activity (ortholog); K48-linked deubiquitinase activity (ortholog); INVOLVED IN negative regulation of proteasomal ubiquitin-dependent protein catabolic process (ortholog); regulation of androgen receptor signaling pathway (ortholog); spermatogenesis (o rtholog); ASSOCIATED WITH Asthenozoospermia (ortholog); male infertility (ortholog); oligospermia (ortholog); FOUND IN nucleoplasm (ortholog); nucleus (ortholog); sperm flagellum (ortholog) | X | 103869903 | 103930495 | Dog | 32 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12673661 | Usp26 | ubiquitin specific peptidase 26 | ENCODES a protein that exhibits deubiquitinase activity (ortholog); K48-linked deubiquitinase activity (ortholog); INVOLVED IN negative regulation of proteasomal ubiquitin-dependent protein catabolic process (ortholog); regulation of androgen receptor signaling pathway (ortholog); spermatogenesis (o rtholog); ASSOCIATED WITH Asthenozoospermia (ortholog); male infertility (ortholog); oligospermia (ortholog); FOUND IN nucleoplasm (ortholog); sperm flagellum (ortholog) | NW_004936691 | 1913416 | 1916214 | Squirrel | 30 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18342952 | USP26 | ubiquitin specific peptidase 26 | ENCODES a protein that exhibits cysteine-type deubiquitinase activity (inferred); cysteine-type peptidase activity (inferred); deubiquitinase activity (inferred); INVOLVED IN G1/S transition of mitotic cell cycle (inferred); negative regulation of proteasomal ubiquitin-dependent protein catabolic pr ocess (inferred); protein deubiquitination (inferred); ASSOCIATED WITH Asthenozoospermia (ortholog); male infertility (ortholog); oligospermia (ortholog); FOUND IN cytoplasm (inferred); cytosol (inferred); nucleoplasm (inferred) | | | | Green Monkey | 31 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 14103372 | USP26 | ubiquitin specific peptidase 26 | ENCODES a protein that exhibits deubiquitinase activity (ortholog); K48-linked deubiquitinase activity (ortholog); INVOLVED IN negative regulation of proteasomal ubiquitin-dependent protein catabolic process (ortholog); regulation of androgen receptor signaling pathway (ortholog); spermatogenesis (o rtholog); ASSOCIATED WITH Asthenozoospermia (ortholog); male infertility (ortholog); oligospermia (ortholog); FOUND IN nucleoplasm (ortholog); nucleus (ortholog); sperm flagellum (ortholog) | | | | Pig | 32 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18930215 | Usp26 | ubiquitin specific peptidase 26 | ENCODES a protein that exhibits deubiquitinase activity (ortholog); K48-linked deubiquitinase activity (ortholog); INVOLVED IN negative regulation of proteasomal ubiquitin-dependent protein catabolic process (ortholog); regulation of androgen receptor signaling pathway (ortholog); spermatogenesis (o rtholog); ASSOCIATED WITH Asthenozoospermia (ortholog); male infertility (ortholog); oligospermia (ortholog); FOUND IN nucleoplasm (ortholog); sperm flagellum (ortholog) | | | | Naked Mole-Rat | 30 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 625954938 | Usp26 | ubiquitin specific peptidase 26 | ENCODES a protein that exhibits deubiquitinase activity (ortholog); K48-linked deubiquitinase activity (ortholog); INVOLVED IN negative regulation of proteasomal ubiquitin-dependent protein catabolic process (ortholog); regulation of androgen receptor signaling pathway (ortholog); spermatogenesis (o rtholog); ASSOCIATED WITH Asthenozoospermia (ortholog); male infertility (ortholog); oligospermia (ortholog); FOUND IN nucleoplasm (ortholog); nucleus (ortholog); sperm flagellum (ortholog) | | | | Black Rat | 18 | symbol | gene, protein-coding, MODEL [RefSeq] |