Usp26 (ubiquitin specific peptidase 26) - Rat Genome Database

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Gene: Usp26 (ubiquitin specific peptidase 26) Mus musculus
Analyze
Symbol: Usp26
Name: ubiquitin specific peptidase 26
RGD ID: 1557856
MGI Page MGI
Description: Predicted to enable K48-linked deubiquitinase activity and cysteine-type deubiquitinase activity. Involved in negative regulation of proteasomal ubiquitin-dependent protein catabolic process. Predicted to be located in nucleoplasm and sperm flagellum. Predicted to be active in cytosol and nucleus. Is expressed in testis. Human ortholog(s) of this gene implicated in spermatogenic failure. Orthologous to human USP26 (ubiquitin specific peptidase 26).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: deubiquitinating enzyme 26; MGC159157; ubiquitin carboxyl-terminal hydrolase 26; ubiquitin specific protease 26; ubiquitin thioesterase 26; ubiquitin thiolesterase 26; ubiquitin-specific-processing protease 26
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39X50,841,544 - 50,890,110 (-)NCBIGRCm39GRCm39mm39
GRCm39 EnsemblX50,842,836 - 50,890,110 (-)EnsemblGRCm39 Ensembl
GRCm38X51,752,667 - 51,801,233 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 EnsemblX51,753,959 - 51,801,233 (-)EnsemblGRCm38mm10GRCm38
MGSCv37X49,107,136 - 49,154,410 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36X47,998,586 - 48,042,380 (-)NCBIMGSCv36mm8
CeleraX39,175,908 - 39,222,874 (-)NCBICelera
Cytogenetic MapXA5NCBI
cM MapX28.31NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cell projection  (IEA)
cilium  (IEA)
cytoplasm  (IEA)
cytoskeleton  (IEA)
cytosol  (IBA,ISO)
motile cilium  (IEA)
nucleoplasm  (ISO)
nucleus  (IBA,ISO)
sperm flagellum  (ISO)

Phenotype Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. MGDs mouse GO annotations MGD data from the GO Consortium
2. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
3. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:10349636   PMID:11042159   PMID:11076861   PMID:11217851   PMID:11279525   PMID:12477932   PMID:16118233   PMID:16141072   PMID:16141073   PMID:21079677   PMID:21267068   PMID:21449984  
PMID:21873635   PMID:22530760   PMID:28839133   PMID:30561524   PMID:30887115   PMID:31201419   PMID:31551464   PMID:32325033   PMID:33064378   PMID:33978233   PMID:34824671   PMID:35091692  
PMID:35857630   PMID:35920200  


Genomics

Comparative Map Data
Usp26
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39X50,841,544 - 50,890,110 (-)NCBIGRCm39GRCm39mm39
GRCm39 EnsemblX50,842,836 - 50,890,110 (-)EnsemblGRCm39 Ensembl
GRCm38X51,752,667 - 51,801,233 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 EnsemblX51,753,959 - 51,801,233 (-)EnsemblGRCm38mm10GRCm38
MGSCv37X49,107,136 - 49,154,410 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36X47,998,586 - 48,042,380 (-)NCBIMGSCv36mm8
CeleraX39,175,908 - 39,222,874 (-)NCBICelera
Cytogenetic MapXA5NCBI
cM MapX28.31NCBI
USP26
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38X133,023,168 - 133,097,109 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 EnsemblX133,023,168 - 133,097,109 (-)EnsemblGRCh38hg38GRCh38
GRCh37X132,157,196 - 132,231,137 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36X131,987,173 - 131,989,966 (-)NCBINCBI36Build 36hg18NCBI36
Build 34X131,885,026 - 131,887,820NCBI
CeleraX132,545,874 - 132,548,667 (-)NCBICelera
Cytogenetic MapXq26.2NCBI
HuRefX121,562,395 - 121,565,188 (-)NCBIHuRef
CHM1_1X132,071,082 - 132,073,875 (-)NCBICHM1_1
T2T-CHM13v2.0X131,347,885 - 131,421,825 (-)NCBIT2T-CHM13v2.0
Usp26
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8X136,237,504 - 136,284,646 (-)NCBIGRCr8
mRatBN7.2X131,317,200 - 131,363,964 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 EnsemblX131,319,194 - 131,363,970 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_UtxX133,476,889 - 133,520,935 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0X137,058,822 - 137,102,868 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0X134,633,247 - 134,677,367 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0X139,030,239 - 139,079,336 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 EnsemblX139,030,804 - 139,079,336 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0X139,084,571 - 139,131,158 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4X138,625,478 - 138,669,690 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
CeleraX130,238,525 - 130,282,649 (-)NCBICelera
Cytogenetic MapXq36NCBI
Usp26
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_0049554731,903,865 - 1,957,747 (+)NCBIChiLan1.0ChiLan1.0
USP26
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2X132,433,181 - 132,493,776 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1X132,436,775 - 132,497,371 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0X122,155,933 - 122,160,000 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1X132,463,139 - 132,465,933 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 EnsemblX132,463,140 - 132,465,887 (-)Ensemblpanpan1.1panPan2
USP26
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1X103,869,903 - 103,930,495 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 EnsemblX103,872,397 - 103,875,171 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_TashaX90,042,316 - 90,060,916 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0X105,726,832 - 105,789,778 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 EnsemblX105,729,326 - 105,732,100 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1X103,140,338 - 103,203,243 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0X105,015,482 - 105,072,425 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0X104,789,168 - 104,852,070 (-)NCBIUU_Cfam_GSD_1.0
Usp26
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2X102,040,698 - 102,044,002 (-)NCBIHiC_Itri_2
SpeTri2.0NW_0049366911,913,416 - 1,916,214 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
USP26
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1X109,092,622 - 109,095,548 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2X125,124,840 - 125,177,383 (-)NCBISscrofa10.2Sscrofa10.2susScr3
USP26
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1X108,187,526 - 108,275,829 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 EnsemblX108,187,858 - 108,190,605 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366606545,699,469 - 45,702,346 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Usp26
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462479712,724,584 - 12,797,308 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Usp26
993 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:500
Count of miRNA genes:216
Interacting mature miRNAs:225
Transcripts:ENSMUST00000069509, ENSMUST00000114869
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1357433Dbts2_mdiabetes 2 (mouse)Not determinedX7226295150107038Mouse
13208553Wght11_mweight 11 (mouse)X1186623959045360Mouse
13208557Lgth13_mbody length 13 (mouse)X1186623959045360Mouse
27226750Femd9_mfemur midshaft diameter 9, 10 week (mouse)X3333746355845360Mouse
27226780Femd12_mfemur midshaft diameter 12, 16 week (mouse)X3466365356845360Mouse
13208567Bmiq12_mbody mass index QTL 12 (mouse)X3526365377043606Mouse
1301009Pbwg7_mpostnatal body weight growth 7 (mouse)Not determinedX3911371473113814Mouse
4141565Pbwg21_mpostnatal body weight growth 21 (mouse)Not determinedX3911371473113814Mouse
1300794Spha2_msperm head anomaly 2 (mouse)Not determinedX3992149886260137Mouse
4142200Rtwq1_mreduced testis weight QTL 1 (mouse)Not determined4147706075477203Mouse
1301278Bdln1_mbody length 1 (mouse)Not determinedX4170210675702218Mouse
1300702Fcsa4_mfemoral cross-sectional area 4 (mouse)Not determinedX4602744480027567Mouse
1301212Bw19_mbody weight QTL 19 (mouse)Not determinedX4637692052412327Mouse
4141630Gct6_mgranulosa cell tumorigenesis 6 (mouse)Not determined47179121129764756Mouse
1300853Aggr2_maggression 2 (mouse)Not determinedX4907116752259196Mouse
1301351Obq6_mobesity QTL 6 (mouse)Not determinedX5077237570434751Mouse

Markers in Region
G65224  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38X51,755,186 - 51,755,391UniSTSGRCm38
MGSCv37X49,108,363 - 49,108,568UniSTSGRCm37
CeleraX39,177,135 - 39,177,340UniSTS
Cytogenetic MapXA5UniSTS
cM MapX UniSTS


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSMUST00000069509   ⟹   ENSMUSP00000069140
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 EnsemblX50,842,836 - 50,890,021 (-)Ensembl
GRCm38.p6 EnsemblX51,753,959 - 51,801,144 (-)Ensembl
RefSeq Acc Id: ENSMUST00000114869   ⟹   ENSMUSP00000110519
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 EnsemblX50,842,836 - 50,890,110 (-)Ensembl
GRCm38.p6 EnsemblX51,753,959 - 51,801,233 (-)Ensembl
RefSeq Acc Id: NM_031388   ⟹   NP_113565
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39X50,842,836 - 50,890,110 (-)NCBI
GRCm38X51,753,959 - 51,801,233 (-)NCBI
MGSCv37X49,107,136 - 49,154,410 (-)RGD
CeleraX39,175,908 - 39,222,874 (-)RGD
cM MapX ENTREZGENE
Sequence:
RefSeq Acc Id: XM_017318645   ⟹   XP_017174134
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39X50,841,544 - 50,890,075 (-)NCBI
GRCm38X51,752,667 - 51,801,198 (-)NCBI
Sequence:
Reference Protein Sequences
RefSeq Acc Id: NP_113565   ⟸   NM_031388
- UniProtKB: Q05A11 (UniProtKB/Swiss-Prot),   Q99MX1 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_017174134   ⟸   XM_017318645
- Peptide Label: isoform X1
- UniProtKB: Q05A11 (UniProtKB/Swiss-Prot),   Q99MX1 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSMUSP00000110519   ⟸   ENSMUST00000114869
RefSeq Acc Id: ENSMUSP00000069140   ⟸   ENSMUST00000069509
Protein Domains
Ubiquitin carboxyl-terminal hydrolase 37 pleckstrin   USP

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q99MX1-F1-model_v2 AlphaFold Q99MX1 1-835 view protein structure

Promoters
RGD ID:6846493
Promoter ID:MM_KWN:60282
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:ES_Cell
Transcripts:NM_031388
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36X49,153,946 - 49,154,446 (-)MPROMDB
RGD ID:13680452
Promoter ID:EPDNEW_M24374
Type:single initiation site
Name:Usp26_1
Description:Mus musculus ubiquitin specific peptidase 26 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38X51,801,082 - 51,801,142EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1933247 AgrOrtholog
Ensembl Genes ENSMUSG00000055780 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000069509 ENTREZGENE
  ENSMUST00000069509.4 UniProtKB/Swiss-Prot
  ENSMUST00000114869 ENTREZGENE
  ENSMUST00000114869.8 UniProtKB/Swiss-Prot
Gene3D-CATH 2.30.29.180 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Cysteine proteinases UniProtKB/Swiss-Prot
InterPro Papain-like_cys_pep_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Peptidase_C19_UCH UniProtKB/Swiss-Prot
  USP37-like_PH UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  USP37-like_PH_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  USP_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  USP_dom UniProtKB/Swiss-Prot
KEGG Report mmu:83563 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGD MGI:1933247 ENTREZGENE
NCBI Gene 83563 ENTREZGENE
PANTHER UBIQUITIN CARBOXYL-TERMINAL HYDROLASE UniProtKB/Swiss-Prot
  UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 26 UniProtKB/Swiss-Prot
Pfam UCH UniProtKB/Swiss-Prot
  UCH_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Usp26 PhenoGen
PROSITE USP_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  USP_2 UniProtKB/Swiss-Prot
  USP_3 UniProtKB/Swiss-Prot
Superfamily-SCOP SSF54001 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt Q05A11 ENTREZGENE
  Q3V059_MOUSE UniProtKB/TrEMBL
  Q8C478_MOUSE UniProtKB/TrEMBL
  Q99MX1 ENTREZGENE, UniProtKB/Swiss-Prot
UniProt Secondary Q05A11 UniProtKB/Swiss-Prot