| 1311825 | Usp14 | ubiquitin specific peptidase 14 | ENCODES a protein that exhibits cysteine-type deubiquitinase activity (ortholog); deubiquitinase activity (ortholog); endopeptidase inhibitor activity (ortholog); INVOLVED IN chemical synaptic transmission (ortholog); inflammatory response (ortholog); negative regulation of ERAD pathway (ortholog); ASSOCIATED WITH distal arthrogryposis (ortholog); FOUND IN cell surface (ortholog); cytoplasm (ortholog); cytoplasmic vesicle (ortholog); INTERACTS WITH (+)-schisandrin B; 2,4,6-trinitrotoluene; 2,4-dinitrotoluene | 18 | 1292745 | 1330867 | Rat | 151 | symbol , PhenoGen | gene, protein-coding, PROVISIONAL [RefSeq] |
| 1323483 | USP14 | ubiquitin specific peptidase 14 | This gene encodes a member of the ubiquitin-specific processing (UBP) family of proteases that is a deubiquitinating enzyme (DUB) with His and Cys domains. This protein is located in the cytoplasm and cleaves the ubiquitin moiety from ubiquitin-fused precursors and ubiquitinylated proteins. Mice wit h a mutation that results in reduced expression of the ortholog of this protein are retarded for growth, develop severe tremors by 2 to 3 weeks of age followed by hindlimb paralysis and death by 6 to 10 weeks of age. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008] | 18 | 158557 | 214629 | Human | 157 | symbol , COSMIC , Human Proteome Map | gene, protein-coding, REVIEWED [RefSeq] |
| 1323484 | Usp14 | ubiquitin specific peptidase 14 | Predicted to enable deubiquitinase activity; endopeptidase inhibitor activity; and proteasome binding activity. Acts upstream of or within chemical synaptic transmission. Located in synapse. Is active in glutamatergic synapse and presynaptic cytosol. Is expressed in several structures, including ali mentary system; cardiovascular system; central nervous system; genitourinary system; and respiratory system. Orthologous to human USP14 (ubiquitin specific peptidase 14). [provided by Alliance of Genome Resources, Jul 2025] | 18 | 9993615 | 10030149 | Mouse | 235 | symbol , PhenoGen , description | gene, protein-coding, VALIDATED [RefSeq] |
| 8795140 | Usp14 | ubiquitin specific peptidase 14 | ENCODES a protein that exhibits cysteine-type deubiquitinase activity (ortholog); deubiquitinase activity (ortholog); endopeptidase inhibitor activity (ortholog); INVOLVED IN chemical synaptic transmission (ortholog); inflammatory response (ortholog); negative regulation of ERAD pathway (ortholog); ASSOCIATED WITH distal arthrogryposis (ortholog); FOUND IN cell surface (ortholog); cytoplasm (ortholog); cytoplasmic vesicle (ortholog) | NW_004955402 | 9710080 | 9737601 | Chinchilla | 25 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 11993211 | USP14 | ubiquitin specific peptidase 14 | ENCODES a protein that exhibits K63-linked deubiquitinase activity (ortholog); INVOLVED IN chemical synaptic transmission (ortholog); ASSOCIATED WITH distal arthrogryposis (ortholog); FOUND IN cell surface (inferred); cytoplasm (inferred); cytoplasmic vesicle (inferred) | 18 | 14104754 | 14158402 | Bonobo | 39 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12384300 | USP14 | ubiquitin specific peptidase 14 | ENCODES a protein that exhibits deubiquitinase activity (ortholog); endopeptidase inhibitor activity (ortholog); K63-linked deubiquitinase activity (ortholog); INVOLVED IN chemical synaptic transmission (ortholog); inflammatory response (ortholog); negative regulation of ubiquitin-dependent protein catabolic process (ortholog); ASSOCIATED WITH distal arthrogryposis (ortholog); FOUND IN cell surface (ortholog); cytoplasm (ortholog); cytoplasmic vesicle (ortholog) | 7 | 67035774 | 67080082 | Dog | 35 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12657520 | Usp14 | ubiquitin specific peptidase 14 | ENCODES a protein that exhibits K63-linked deubiquitinase activity (ortholog); INVOLVED IN chemical synaptic transmission (ortholog); ASSOCIATED WITH distal arthrogryposis (ortholog); FOUND IN cell surface (inferred); cytoplasm (inferred); cytoplasmic vesicle (inferred) | NW_004936550 | 640331 | 675703 | Squirrel | 39 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 14221744 | USP14 | ubiquitin specific peptidase 14 | ENCODES a protein that exhibits K63-linked deubiquitinase activity (ortholog); INVOLVED IN chemical synaptic transmission (ortholog); ASSOCIATED WITH distal arthrogryposis (ortholog); FOUND IN cell surface (inferred); cytoplasm (inferred); cytoplasmic vesicle (inferred) | | | | Pig | 38 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 626062667 | Usp14 | ubiquitin specific peptidase 14 | ENCODES a protein that exhibits cysteine-type deubiquitinase activity (ortholog); deubiquitinase activity (ortholog); endopeptidase inhibitor activity (ortholog); INVOLVED IN chemical synaptic transmission (ortholog); inflammatory response (ortholog); negative regulation of ERAD pathway (ortholog); ASSOCIATED WITH distal arthrogryposis (ortholog); FOUND IN cell surface (ortholog); cytoplasm (ortholog); cytoplasmic vesicle (ortholog) | | | | Black Rat | 25 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18420370 | USP14 | ubiquitin specific peptidase 14 | ENCODES a protein that exhibits K63-linked deubiquitinase activity (ortholog); INVOLVED IN chemical synaptic transmission (ortholog); ASSOCIATED WITH distal arthrogryposis (ortholog); FOUND IN cell surface (inferred); cytoplasm (inferred); cytoplasmic vesicle (inferred) | | | | Green Monkey | 39 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 14389119 | Usp14 | | | | | | Fly | | symbol | gene, null |
| 18923353 | Usp14 | ubiquitin specific peptidase 14 | ENCODES a protein that exhibits deubiquitinase activity (ortholog); endopeptidase inhibitor activity (ortholog); K63-linked deubiquitinase activity (ortholog); INVOLVED IN chemical synaptic transmission (ortholog); inflammatory response (ortholog); negative regulation of ERAD pathway (ortholog); ASS OCIATED WITH distal arthrogryposis (ortholog); FOUND IN cell surface (ortholog); cytoplasm (ortholog); cytoplasmic vesicle (ortholog) | | | | Naked Mole-Rat | 36 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 155231810 | usp14 | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 155231811 | usp14.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 155249460 | usp14.S | | | | | | African Clawed Frog | | symbol | gene, null |