| 620975 | Usf2 | upstream transcription factor 2, c-fos interacting | ENCODES a protein that exhibits DNA-binding transcription factor activity; DNA-binding transcription factor activity, RNA polymerase II-specific; double-stranded DNA binding; INVOLVED IN positive regulation of transcription by RNA polymerase II; cellular response to glucose stimulus (ortholog); gluc ose mediated signaling pathway (ortholog); ASSOCIATED WITH prostate cancer (ortholog); FOUND IN nucleoplasm (ortholog); nucleus (ortholog); INTERACTS WITH 1,2-dimethylhydrazine; 2,3,7,8-tetrachlorodibenzodioxine; ammonium chloride | 1 | 95302109 | 95321334 | Rat | 123 | symbol , old_gene_name , PhenoGen | gene, protein-coding, PROVISIONAL [RefSeq] |
| 734370 | USF2 | upstream transcription factor 2, c-fos interacting | This gene encodes a member of the basic helix-loop-helix leucine zipper family of transcription factors. The encoded protein can activate transcription through pyrimidine-rich initiator (Inr) elements and E-box motifs and is involved in regulating multiple cellular processes. [provided by RefSeq, Ma r 2016] | 19 | 35268962 | 35279821 | Human | 131 | symbol , COSMIC , Human Proteome Map | gene, protein-coding, REVIEWED [RefSeq] |
| 734371 | Usf2 | upstream transcription factor 2 | Enables DNA binding activity and DNA-binding transcription activator activity, RNA polymerase II-specific. Involved in glucose mediated signaling pathway; lipid homeostasis; and positive regulation of transcription from RNA polymerase II promoter by glucose. Acts upstream of or within lactation; pos itive regulation of DNA-templated transcription; and regulation of transcription by RNA polymerase II. Located in nucleus. Is expressed in several structures, including central nervous system; dorsal root ganglion; early conceptus; genitourinary system; and sensory organ. Orthologous to human USF2 (upstream transcription factor 2, c-fos interacting). [provided by Alliance of Genome Resources, Jul 2025] | 7 | 30645421 | 30656288 | Mouse | 150 | symbol , PhenoGen , description | gene, protein-coding, VALIDATED [RefSeq] |
| 8779520 | Usf2 | upstream transcription factor 2, c-fos interacting | ENCODES a protein that exhibits bHLH transcription factor binding (ortholog); DNA binding (ortholog); DNA-binding transcription activator activity, RNA polymerase II-specific (ortholog); INVOLVED IN cellular response to glucose stimulus (ortholog); glucose mediated signaling pathway (ortholog); lact ation (ortholog); ASSOCIATED WITH prostate cancer (ortholog); FOUND IN nucleoplasm (ortholog); nucleus (ortholog) | NW_004955468 | 4565089 | 4574294 | Chinchilla | 40 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 11713869 | USF2 | upstream transcription factor 2, c-fos interacting | ENCODES a protein that exhibits bHLH transcription factor binding (ortholog); DNA binding (ortholog); DNA-binding transcription activator activity, RNA polymerase II-specific (ortholog); INVOLVED IN cellular response to glucose stimulus (ortholog); glucose mediated signaling pathway (ortholog); lact ation (ortholog); ASSOCIATED WITH prostate cancer (ortholog); FOUND IN nucleoplasm (ortholog); nucleus (ortholog) | 19 | 32215305 | 32226172 | Bonobo | 40 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12137326 | USF2 | upstream transcription factor 2, c-fos interacting | ENCODES a protein that exhibits DNA-binding transcription factor activity (ortholog); DNA-binding transcription factor activity, RNA polymerase II-specific (ortholog); double-stranded DNA binding (ortholog); INVOLVED IN lactation (ortholog); positive regulation of DNA-templated transcription (orthol og); positive regulation of transcription by RNA polymerase II (ortholog); ASSOCIATED WITH prostate cancer (ortholog); FOUND IN nucleoplasm (inferred); nucleus (inferred) | 1 | 117308882 | 117319397 | Dog | 41 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12581681 | Usf2 | upstream transcription factor 2, c-fos interacting | ENCODES a protein that exhibits DNA-binding transcription factor activity (ortholog); DNA-binding transcription factor activity, RNA polymerase II-specific (ortholog); double-stranded DNA binding (ortholog); INVOLVED IN lactation (ortholog); positive regulation of DNA-templated transcription (orthol og); positive regulation of transcription by RNA polymerase II (ortholog); ASSOCIATED WITH prostate cancer (ortholog); FOUND IN nucleoplasm (inferred); nucleus (inferred) | NW_004936570 | 1012696 | 1024243 | Squirrel | 41 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18633455 | USF2 | upstream transcription factor 2, c-fos interacting | ENCODES a protein that exhibits DNA-binding transcription factor activity (ortholog); DNA-binding transcription factor activity, RNA polymerase II-specific (ortholog); double-stranded DNA binding (ortholog); INVOLVED IN lactation (ortholog); positive regulation of DNA-templated transcription (orthol og); positive regulation of transcription by RNA polymerase II (ortholog); ASSOCIATED WITH prostate cancer (ortholog); FOUND IN nucleoplasm (inferred); nucleus (inferred) | | | | Green Monkey | 41 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 155241007 | usf2 | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 625835972 | Usf2 | upstream transcription factor 2, c-fos interacting | ENCODES a protein that exhibits bHLH transcription factor binding (ortholog); DNA binding (ortholog); DNA-binding transcription activator activity, RNA polymerase II-specific (ortholog); INVOLVED IN cellular response to glucose stimulus (ortholog); glucose mediated signaling pathway (ortholog); lact ation (ortholog); ASSOCIATED WITH prostate cancer (ortholog); FOUND IN nucleoplasm (ortholog); nucleus (ortholog) | | | | Black Rat | 39 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18910149 | Usf2 | upstream transcription factor 2, c-fos interacting | ENCODES a protein that exhibits DNA-binding transcription factor activity (ortholog); DNA-binding transcription factor activity, RNA polymerase II-specific (ortholog); double-stranded DNA binding (ortholog); INVOLVED IN lactation (ortholog); positive regulation of DNA-templated transcription (orthol og); positive regulation of transcription by RNA polymerase II (ortholog); ASSOCIATED WITH prostate cancer (ortholog); FOUND IN nucleoplasm (inferred); nucleus (inferred) | | | | Naked Mole-Rat | 41 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 13960536 | USF2 | upstream transcription factor 2, c-fos interacting | ENCODES a protein that exhibits DNA-binding transcription factor activity (ortholog); DNA-binding transcription factor activity, RNA polymerase II-specific (ortholog); double-stranded DNA binding (ortholog); INVOLVED IN lactation (ortholog); positive regulation of DNA-templated transcription (orthol og); positive regulation of transcription by RNA polymerase II (ortholog); ASSOCIATED WITH prostate cancer (ortholog); FOUND IN nucleoplasm (inferred); nucleus (inferred) | | | | Pig | 41 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 155249861 | usf2.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 155259692 | usf2.S | | | | | | African Clawed Frog | | symbol | gene, null |
| 1623022 | Usf2-ps1 | upstream transcription factor 2, pseudogene 1 | | 7 | 30625358 | 30626571 | Mouse | | symbol , PhenoGen | gene, pseudo, INFERRED [RefSeq] |
| 1551792 | Usf1 | upstream transcription factor 1 | This protein encoded by this gene is a member of the basic-Helix-Hoop-Helix-Leucine zipper (bHLH-LZ) family and encodes a protein that can act as a transcription factor. Studies indicate that the basic region interacts with DNA at E-Box motifs, while the helix-loop-helix and leucine zipper domains a re involved in dimerization with different partners. This protein is involved in a wide array of biological pathways, including cell cycle regulation, immune response, and responses to ultraviolet radiation. Mice lacking most of the coding exons of this gene often lacked both whiskers and nasal fur, and were prone to epileptic seizures, while mice lacking both this gene and another family member, Usf2, displayed embryonic lethality (PMID:9520440). Mutations in the human ortholog of this gene have been associated with Familial Combined Hyperlipidemia (FCHL) in humans. Pseudogenes of this gene are found on chromosome 11 and the X chromosome. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Mar 2015] | 1 | 171238881 | 171246327 | Mouse | 165 | description | gene, protein-coding, REVIEWED [RefSeq] |