ENCODES a protein that exhibits ISG15 activating enzyme activity (ortholog); ubiquitin-protein transferase activity (ortholog); INVOLVED IN innate immune response (ortholog); ISG15-protein conjugation (ortholog); modification-dependent protein catabolic process (ortholog); PARTICIPATES IN Parkinson'
s disease pathway; ubiquitin/proteasome degradation pathway; ASSOCIATED WITH intellectual disability (ortholog); squamous cell carcinoma (ortholog); FOUND IN cytoplasm (ortholog); INTERACTS WITH 17alpha-ethynylestradiol; 17beta-estradiol; 17beta-estradiol 3-benzoate
The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein
ligases, or E3s. This gene encodes a member of the E1 ubiquitin-activating enzyme family. The encoded enzyme is a retinoid target that triggers promyelocytic leukemia (PML)/retinoic acid receptor alpha (RARalpha) degradation and apoptosis in acute promyelocytic leukemia, where it is involved in the conjugation of the ubiquitin-like interferon-stimulated gene 15 protein. [provided by RefSeq, Jul 2008]
3
49805209
49813953
Human
162
symbol , old_gene_name , COSMIC , Human Proteome Map
Enables ISG15 activating enzyme activity. Acts upstream of or within ISG15-protein conjugation and modification-dependent protein catabolic process. Predicted to be located in nucleus. Predicted to be active in cytoplasm. Is expressed in liver lobe and thymus primordium. Orthologous to human UBA7
ENCODES a protein that exhibits ISG15 activating enzyme activity (ortholog); ubiquitin-protein transferase activity (ortholog); INVOLVED IN innate immune response (ortholog); ISG15-protein conjugation (ortholog); modification-dependent protein catabolic process (ortholog); ASSOCIATED WITH intellectu
ENCODES a protein that exhibits ubiquitin-protein transferase activity (ortholog); INVOLVED IN ISG15-protein conjugation (ortholog); modification-dependent protein catabolic process (ortholog); ASSOCIATED WITH intellectual disability (ortholog); squamous cell carcinoma (ortholog); FOUND IN cytoplasm
ENCODES a protein that exhibits ubiquitin-protein transferase activity (ortholog); INVOLVED IN ISG15-protein conjugation (ortholog); modification-dependent protein catabolic process (ortholog); ASSOCIATED WITH intellectual disability (ortholog); squamous cell carcinoma (ortholog); FOUND IN cytoplasm
ENCODES a protein that exhibits ubiquitin-protein transferase activity (ortholog); INVOLVED IN ISG15-protein conjugation (ortholog); modification-dependent protein catabolic process (ortholog); ASSOCIATED WITH intellectual disability (ortholog); squamous cell carcinoma (ortholog); FOUND IN cytoplasm
ENCODES a protein that exhibits ubiquitin-protein transferase activity (ortholog); INVOLVED IN ISG15-protein conjugation (ortholog); modification-dependent protein catabolic process (ortholog); ASSOCIATED WITH intellectual disability (ortholog); squamous cell carcinoma (ortholog); FOUND IN cytoplasm
ENCODES a protein that exhibits ubiquitin-protein transferase activity (ortholog); INVOLVED IN ISG15-protein conjugation (ortholog); modification-dependent protein catabolic process (ortholog); ASSOCIATED WITH intellectual disability (ortholog); squamous cell carcinoma (ortholog); FOUND IN cytoplasm
ENCODES a protein that exhibits ubiquitin-protein transferase activity (ortholog); INVOLVED IN ISG15-protein conjugation (ortholog); modification-dependent protein catabolic process (ortholog); ASSOCIATED WITH intellectual disability (ortholog); squamous cell carcinoma (ortholog); FOUND IN cytoplasm
ENCODES a protein that exhibits ISG15 activating enzyme activity (ortholog); ubiquitin-protein transferase activity (ortholog); INVOLVED IN innate immune response (ortholog); ISG15-protein conjugation (ortholog); modification-dependent protein catabolic process (ortholog); ASSOCIATED WITH intellectu
