Uba7 (ubiquitin like modifier activating enzyme 7) - Rat Genome Database

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Gene: Uba7 (ubiquitin like modifier activating enzyme 7) Heterocephalus glaber
Analyze
Symbol: Uba7
Name: ubiquitin like modifier activating enzyme 7
RGD ID: 18910433
Description: ENCODES a protein that exhibits ubiquitin-protein transferase activity (ortholog); INVOLVED IN ISG15-protein conjugation (ortholog); modification-dependent protein catabolic process (ortholog); ASSOCIATED WITH Aicardi-Goutieres Syndrome 1 (ortholog); developmental and epileptic encephalopathy (ortholog); early infantile epileptic encephalopathy (ortholog); FOUND IN cytoplasm (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: ubiquitin-like modifier-activating enzyme 7
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Alliance Genes
More Info more info ...
Latest Assembly: HetGla 1.0 - Naked Mole-Rat female 1.0 Assembly
Position:
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247303,718,573 - 3,730,097 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247303,720,516 - 3,729,586 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytoplasm  (IEA,ISO)

References
Additional References at PubMed
PMID:30032202  


Genomics

Comparative Map Data
Uba7
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247303,718,573 - 3,730,097 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247303,720,516 - 3,729,586 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2
UBA7
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38349,805,209 - 49,813,953 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl349,805,209 - 49,813,953 (-)EnsemblGRCh38hg38GRCh38
GRCh37349,842,642 - 49,851,386 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36349,817,642 - 49,826,395 (-)NCBINCBI36Build 36hg18NCBI36
Build 34349,817,642 - 49,826,395NCBI
Celera349,808,165 - 49,816,714 (-)NCBICelera
Cytogenetic Map3p21.31NCBI
HuRef349,901,687 - 49,910,450 (-)NCBIHuRef
CHM1_1349,794,699 - 49,803,452 (-)NCBICHM1_1
T2T-CHM13v2.0349,835,086 - 49,843,840 (-)NCBIT2T-CHM13v2.0
Uba7
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm399107,852,766 - 107,861,255 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl9107,852,704 - 107,861,259 (+)EnsemblGRCm39 Ensembl
GRCm389107,975,567 - 107,984,056 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl9107,975,505 - 107,984,060 (+)EnsemblGRCm38mm10GRCm38
MGSCv379107,877,898 - 107,886,387 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv369107,833,668 - 107,842,157 (+)NCBIMGSCv36mm8
Celera9107,583,980 - 107,592,467 (+)NCBICelera
Cytogenetic Map9F1NCBI
cM Map959.07NCBI
Uba7
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr88117,543,902 - 117,552,709 (+)NCBIGRCr8
mRatBN7.28108,665,289 - 108,674,097 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl8108,665,292 - 108,674,099 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx8114,291,762 - 114,300,571 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.08112,491,085 - 112,499,894 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.08110,333,725 - 110,342,534 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.08116,754,178 - 116,766,765 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl8116,754,178 - 116,764,126 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.08116,108,502 - 116,121,088 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.48113,244,829 - 113,253,636 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.18113,264,139 - 113,272,984 (+)NCBI
Celera8107,969,920 - 107,978,739 (+)NCBICelera
Cytogenetic Map8q32NCBI
Uba7
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555321,695,956 - 1,706,676 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049555321,697,667 - 1,706,668 (-)NCBIChiLan1.0ChiLan1.0
UBA7
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2249,791,441 - 49,800,294 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1349,796,214 - 49,805,018 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0349,737,015 - 49,745,783 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1350,973,211 - 50,981,997 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl350,973,211 - 50,981,997 (-)Ensemblpanpan1.1panPan2
UBA7
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12039,459,981 - 39,468,919 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2039,460,216 - 39,468,917 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2039,380,946 - 39,389,763 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02039,816,971 - 39,825,794 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2039,816,974 - 39,838,844 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12039,184,003 - 39,192,827 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02039,588,249 - 39,597,062 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02039,867,799 - 39,876,629 (+)NCBIUU_Cfam_GSD_1.0
Uba7
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440560264,651,699 - 64,660,747 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365291,412,194 - 1,421,197 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365291,412,196 - 1,421,216 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
UBA7
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1332,332,367 - 32,341,217 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11332,330,536 - 32,341,300 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21335,509,800 - 35,520,514 (-)NCBISscrofa10.2Sscrofa10.2susScr3
UBA7
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12211,208,744 - 11,217,834 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2211,207,417 - 11,217,734 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666041155,780,703 - 155,789,500 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSHGLT00000016346   ⟹   ENSHGLP00000016177
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla_female_1.0 EnsemblNW_0046247303,718,573 - 3,730,097 (-)Ensembl
RefSeq Acc Id: XM_013070152   ⟹   XP_012925606
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_0046247303,720,516 - 3,729,584 (-)NCBI
RefSeq Acc Id: XM_021263729   ⟹   XP_021119388
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_0046247303,720,516 - 3,729,584 (-)NCBI
RefSeq Acc Id: XM_021263734   ⟹   XP_021119393
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_0046247303,721,482 - 3,729,585 (-)NCBI
RefSeq Acc Id: XM_021263773   ⟹   XP_021119432
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_0046247303,720,516 - 3,729,257 (-)NCBI
RefSeq Acc Id: XR_002397179
Type: NON-CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_0046247303,723,312 - 3,729,586 (-)NCBI
Protein Sequences
Protein RefSeqs XP_012925606 (Get FASTA)   NCBI Sequence Viewer  
  XP_021119388 (Get FASTA)   NCBI Sequence Viewer  
  XP_021119393 (Get FASTA)   NCBI Sequence Viewer  
  XP_021119432 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSHGLP00000016177
Reference Protein Sequences
RefSeq Acc Id: XP_021119388   ⟸   XM_021263729
- Peptide Label: isoform X2
- UniProtKB: G5BZX5 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_012925606   ⟸   XM_013070152
- Peptide Label: isoform X1
- UniProtKB: G5BZX5 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_021119432   ⟸   XM_021263773
- Peptide Label: isoform X4
- UniProtKB: G5BZX5 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_021119393   ⟸   XM_021263734
- Peptide Label: isoform X3
- UniProtKB: G5BZX5 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSHGLP00000016177   ⟸   ENSHGLT00000016346


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSHGLG00000011581 Ensembl, ENTREZGENE
Ensembl Transcript ENSHGLT00000016346 ENTREZGENE
Gene3D-CATH NAD(P)-binding Rossmann-like Domain UniProtKB/TrEMBL
  Ubiquitin-activating enzyme E1, FCCH domain UniProtKB/TrEMBL
  Ubiquitin-activating enzyme E1, inactive adenylation domain, subdomain 1 UniProtKB/TrEMBL
  Ubiquitin-activating enzyme E1, inactive adenylation domain, subdomain 2 UniProtKB/TrEMBL
  Ubiquitin-activating enzyme E1, SCCH domain UniProtKB/TrEMBL
  Ubiquitin-activating enzyme E1, UFD domain UniProtKB/TrEMBL
InterPro E1_4HB UniProtKB/TrEMBL
  E1_FCCH UniProtKB/TrEMBL
  E1_FCCH_sf UniProtKB/TrEMBL
  ThiF/MoeB/HesA UniProtKB/TrEMBL
  ThiF_NAD_FAD-bd UniProtKB/TrEMBL
  Ub-activating_enz_E1_C UniProtKB/TrEMBL
  Ub-E1_IAD_1 UniProtKB/TrEMBL
  UBA_E1_C_sf UniProtKB/TrEMBL
  UBA_E1_SCCH UniProtKB/TrEMBL
  Ubi_acti_E1_SCCH UniProtKB/TrEMBL
  Ubiquitin-activating_enz UniProtKB/TrEMBL
  UBQ-activ_enz_E1 UniProtKB/TrEMBL
  UBQ-activ_enz_E1_Cys_AS UniProtKB/TrEMBL
  UBQ/SUMO-activ_enz_E1-like UniProtKB/TrEMBL
NCBI Gene Uba7 ENTREZGENE
PANTHER UBIQUITIN-ACTIVATING ENZYME E1 UniProtKB/TrEMBL
  UBIQUITIN-LIKE MODIFIER-ACTIVATING ENZYME 7 UniProtKB/TrEMBL
Pfam E1_4HB UniProtKB/TrEMBL
  E1_FCCH UniProtKB/TrEMBL
  E1_UFD UniProtKB/TrEMBL
  ThiF UniProtKB/TrEMBL
  UBA_E1_SCCH UniProtKB/TrEMBL
PRINTS UBIQUITINACT UniProtKB/TrEMBL
PROSITE UBIQUITIN_ACTIVAT_2 UniProtKB/TrEMBL
SMART UBA_e1_C UniProtKB/TrEMBL
Superfamily-SCOP Activating enzymes of the ubiquitin-like proteins UniProtKB/TrEMBL
UniProt G5BZX5 ENTREZGENE, UniProtKB/TrEMBL