| 1345321 | TSSK4 | testis specific serine kinase 4 | This gene encodes a member of the testis-specific serine/threonine kinase family. The encoded protein is thought to be involved in spermatogenesis via stimulation of the CREB/CRE responsive pathway through phosphorylation of the cAMP responsive element binding protein transcription factor. Alternati ve splicing results in multiple transcript variants.[provided by RefSeq, May 2010] | 14 | 24205696 | 24208248 | Human | 75 | symbol , COSMIC , Human Proteome Map | gene, protein-coding, REVIEWED [RefSeq] |
| 1557156 | Tssk4 | testis-specific serine kinase 4 | Enables magnesium ion binding activity; protein homodimerization activity; and protein serine/threonine kinase activity. Involved in several processes, including flagellated sperm motility; positive regulation of CREB transcription factor activity; and protein phosphorylation. Located in sperm flage llum. Orthologous to human TSSK4 (testis specific serine kinase 4). [provided by Alliance of Genome Resources, Jul 2025] | 14 | 55880893 | 55889996 | Mouse | 86 | symbol , PhenoGen , description | gene, protein-coding, VALIDATED [RefSeq] |
| 1560814 | Tssk4 | testis-specific serine kinase 4 | ENCODES a protein that exhibits ATP binding (ortholog); identical protein binding (ortholog); magnesium ion binding (ortholog); INVOLVED IN fertilization (ortholog); flagellated sperm motility (ortholog); obsolete positive regulation of CREB transcription factor activity (ortholog); FOUND IN motile cilium (ortholog); sperm flagellum (ortholog); INTERACTS WITH aflatoxin B1; bisphenol A; endosulfan | 15 | 33108248 | 33114083 | Rat | 72 | symbol , PhenoGen | gene, protein-coding, VALIDATED [RefSeq] |
| 8938752 | Tssk4 | testis specific serine kinase 4 | ENCODES a protein that exhibits ATP binding (ortholog); identical protein binding (ortholog); magnesium ion binding (ortholog); INVOLVED IN fertilization (ortholog); flagellated sperm motility (ortholog); obsolete positive regulation of CREB transcription factor activity (ortholog); FOUND IN motile cilium (ortholog); sperm flagellum (ortholog) | NW_004955409 | 36190182 | 36191801 | Chinchilla | 26 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 11790055 | TSSK4 | testis specific serine kinase 4 | ENCODES a protein that exhibits protein kinase activity (ortholog); INVOLVED IN flagellated sperm motility (ortholog); obsolete positive regulation of CREB transcription factor activity (ortholog); peptidyl-serine phosphorylation (ortholog); FOUND IN acrosomal vesicle (inferred); cytoplasm (inferred ); cytoplasmic vesicle (inferred) | 14 | 4980178 | 4984291 | Bonobo | 47 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12060935 | TSSK4 | testis specific serine kinase 4 | ENCODES a protein that exhibits protein kinase activity (ortholog); INVOLVED IN flagellated sperm motility (ortholog); obsolete positive regulation of CREB transcription factor activity (ortholog); peptidyl-serine phosphorylation (ortholog); FOUND IN cytoplasmic vesicle (inferred); motile cilium (in ferred); sperm flagellum (inferred) | 8 | 4192060 | 4195052 | Dog | 43 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12619818 | Tssk4 | testis specific serine kinase 4 | ENCODES a protein that exhibits protein kinase activity (ortholog); INVOLVED IN flagellated sperm motility (ortholog); obsolete positive regulation of CREB transcription factor activity (ortholog); peptidyl-serine phosphorylation (ortholog); FOUND IN acrosomal vesicle (inferred); cytoplasm (inferred ); cytoplasmic vesicle (inferred) | NW_004936722 | 345698 | 348531 | Squirrel | 46 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 14081706 | TSSK4 | testis specific serine kinase 4 | ENCODES a protein that exhibits protein kinase activity (ortholog); INVOLVED IN flagellated sperm motility (ortholog); obsolete positive regulation of CREB transcription factor activity (ortholog); peptidyl-serine phosphorylation (ortholog); FOUND IN cytoplasmic vesicle (inferred); motile cilium (in ferred); sperm flagellum (inferred) | | | | Pig | 43 | symbol | gene, protein-coding, PROVISIONAL [RefSeq] |
| 626144211 | Tssk4 | testis specific serine kinase 4 | ENCODES a protein that exhibits ATP binding (ortholog); identical protein binding (ortholog); magnesium ion binding (ortholog); INVOLVED IN fertilization (ortholog); flagellated sperm motility (ortholog); obsolete positive regulation of CREB transcription factor activity (ortholog); FOUND IN motile cilium (ortholog); sperm flagellum (ortholog) | | | | Black Rat | 26 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18901499 | Tssk4 | testis specific serine kinase 4 | ENCODES a protein that exhibits identical protein binding (ortholog); protein homodimerization activity (ortholog); protein kinase activity (ortholog); INVOLVED IN fertilization (ortholog); flagellated sperm motility (ortholog); obsolete positive regulation of CREB transcription factor activity (ort holog); FOUND IN sperm flagellum (ortholog) | | | | Naked Mole-Rat | 41 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 39131429 | TSSK4 | testis specific serine kinase 4 | | | | | Chinchilla | | symbol | gene, protein-coding |
| 18725785 | TSSK4 | testis specific serine kinase 4 | ENCODES a protein that exhibits protein kinase activity (ortholog); INVOLVED IN flagellated sperm motility (ortholog); obsolete positive regulation of CREB transcription factor activity (ortholog); peptidyl-serine phosphorylation (ortholog); FOUND IN acrosomal vesicle (inferred); cytoplasm (inferred ); cytoplasmic vesicle (inferred) | | | | Green Monkey | 47 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 1605019 | TSSK6 | testis specific serine kinase 6 | This intronless gene encodes a member of the CAMK (calcium/calmodulin-dependent) serine/threonine protein kinase family. The encoded kinase has a broad expression pattern but is described as testis-specific due to effects on fertility. Male mice which lack the gene encoding a highly similar protein are sterile and have morphologically abnormal sperm. [provided by RefSeq, Jan 2012] | 19 | 19514219 | 19515548 | Human | 74 | old_gene_symbol | gene, protein-coding, REVIEWED [RefSeq] |