TSSK6 (testis specific serine kinase 6)

Gene: TSSK6 (testis specific serine kinase 6) Homo sapiens

Analyze

Symbol:

TSSK6

Name:

testis specific serine kinase 6

RGD ID:

1605019

HGNC Page

HGNC:30410

Description:

Enables ATP binding activity; magnesium ion binding activity; and protein serine/threonine kinase activity. Predicted to be involved in sperm DNA condensation. Located in nucleus.

Type:

protein-coding

RefSeq Status:

REVIEWED

Previously known as:

cancer/testis antigen 72; CT72; FKSG82; FLJ24002; serine/threonine protein kinase SSTK; serine/threonine-protein kinase SSTK; small serine/threonine kinase; SSTK; testis secretory sperm-binding protein Li 205a; testis-specific kinase 6; testis-specific serine kinase 6; testis-specific serine/threonine-protein kinase 6; TSK-6; TSSK-6; TSSK4

RGD Orthologs

Alliance Genes

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Mus musculus (house mouse):	Tssk6 (testis-specific serine kinase 6)	HGNC	Ensembl, HGNC, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, Panther, PhylomeDB
Rattus norvegicus (Norway rat):	Tssk6 (testis-specific serine kinase 6)	HGNC	Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, Panther
Chinchilla lanigera (long-tailed chinchilla):	Tssk6 (testis specific serine kinase 6)	NCBI	Ortholog
Pan paniscus (bonobo/pygmy chimpanzee):	TSSK6 (testis specific serine kinase 6)	NCBI	Ortholog
Canis lupus familiaris (dog):	TSSK6 (testis specific serine kinase 6)	HGNC	Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, Panther
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Tssk6 (testis specific serine kinase 6)	NCBI	Ortholog
Sus scrofa (pig):	TSSK6 (testis specific serine kinase 6)	HGNC	Ensembl, NCBI, OMA, OrthoDB, Panther
Chlorocebus sabaeus (green monkey):	TSSK6 (testis specific serine kinase 6)	NCBI	Ortholog
Heterocephalus glaber (naked mole-rat):	Tssk6 (testis specific serine kinase 6)	NCBI	Ortholog
Other homologs ²
Rattus norvegicus (Norway rat):	Sike1 (suppressor of IKBKE 1)	HGNC	OMA
Alliance orthologs ³
Mus musculus (house mouse):	Tssk6 (testis-specific serine kinase 6)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Rattus norvegicus (Norway rat):	Tssk6 (testis-specific serine kinase 6)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	tssk6 (testis-specific serine kinase 6)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid\|ZFIN)
Caenorhabditis elegans (roundworm):	C27D6.11	Alliance	DIOPT (Ensembl Compara\|InParanoid\|OMA\|OrthoInspector\|PANTHER\|SonicParanoid)
Caenorhabditis elegans (roundworm):	Y38H8A.4	Alliance	DIOPT (Ensembl Compara\|InParanoid\|OMA\|OrthoInspector\|PANTHER\|SonicParanoid)
Caenorhabditis elegans (roundworm):	tag-344	Alliance	DIOPT (Ensembl Compara\|InParanoid\|OMA\|OrthoInspector\|PANTHER\|SonicParanoid)
Saccharomyces cerevisiae (baker's yeast):	SKS1	Alliance	DIOPT (Ensembl Compara\|PANTHER)
Saccharomyces cerevisiae (baker's yeast):	VHS1	Alliance	DIOPT (Ensembl Compara\|PANTHER)

Allele / Splice:

See ClinVar data

Latest Assembly:

GRCh38 - Human Genome Assembly GRCh38

Position:

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	19	19,514,219 - 19,515,548 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	19	19,512,418 - 19,515,548 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	19	19,625,028 - 19,626,357 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	19	19,486,028 - 19,487,469 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Celera	19	19,529,087 - 19,530,528 (-)	NCBI		Celera
Cytogenetic Map	19	p13.11	NCBI
HuRef	19	19,187,321 - 19,188,762 (-)	NCBI		HuRef
CHM1_1	19	19,625,724 - 19,627,165 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	19	19,651,706 - 19,653,035 (-)	NCBI		T2T-CHM13v2.0

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

genetic disease (IAGP)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

1,2-dimethylhydrazine (ISO)

2,3,7,8-tetrachlorodibenzodioxine (ISO)

4,4'-diaminodiphenylmethane (ISO)

4,4'-sulfonyldiphenol (ISO)

acrylamide (EXP,ISO)

aristolochic acid A (EXP)

benzo[a]pyrene (EXP,ISO)

bisphenol A (ISO)

cadmium atom (EXP)

choline (ISO)

cisplatin (EXP)

clothianidin (EXP)

endosulfan (ISO)

folic acid (EXP,ISO)

gentamycin (ISO)

iron dichloride (EXP)

L-methionine (ISO)

paracetamol (ISO)

sodium arsenite (ISO)

triptonide (ISO)

urethane (EXP)

valproic acid (EXP)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

cell differentiation (IEA)

intracellular signal transduction (IEA)

sperm DNA condensation (IEA,ISS)

spermatogenesis (IEA)

Cellular Component

cytoplasm (IEA)

nucleus (HDA)

Molecular Function

ATP binding (IDA,IEA)

magnesium ion binding (IDA,IEA)

metal ion binding (IEA)

protein binding (IPI)

protein kinase activity (IEA)

protein serine kinase activity (IEA)

protein serine/threonine kinase activity (IBA,IDA,IEA)

protein-containing complex binding (IEA)

References

References - curated

#	Reference Title	Reference Citation
1.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions

Additional References at PubMed

PMID:12477932	PMID:14702039	PMID:15044604	PMID:15489334	PMID:15870294	PMID:20037600	PMID:20829357	PMID:21630459	PMID:21832049	PMID:21873635	PMID:22939624	PMID:23974872
PMID:25036637	PMID:25056061	PMID:25852190	PMID:32707033	PMID:33961781

Genomics

Comparative Map Data

TSSK6
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	19	19,514,219 - 19,515,548 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	19	19,512,418 - 19,515,548 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	19	19,625,028 - 19,626,357 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	19	19,486,028 - 19,487,469 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Celera	19	19,529,087 - 19,530,528 (-)	NCBI		Celera
Cytogenetic Map	19	p13.11	NCBI
HuRef	19	19,187,321 - 19,188,762 (-)	NCBI		HuRef
CHM1_1	19	19,625,724 - 19,627,165 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	19	19,651,706 - 19,653,035 (-)	NCBI		T2T-CHM13v2.0

Tssk6
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	8	70,354,834 - 70,356,168 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	8	70,354,834 - 70,356,168 (+)	Ensembl		GRCm39 Ensembl
GRCm38	8	69,902,184 - 69,903,518 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	8	69,902,184 - 69,903,518 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	8	72,426,114 - 72,427,417 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	8	72,831,204 - 72,832,507 (+)	NCBI		MGSCv36	mm8
Celera	8	72,462,020 - 72,463,323 (+)	NCBI		Celera
Cytogenetic Map	8	B3.3	NCBI
cM Map	8	34.05	NCBI

Tssk6
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	16	19,551,757 - 19,559,918 (-)	NCBI		GRCr8
mRatBN7.2	16	19,523,626 - 19,526,074 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	16	19,517,334 - 19,526,090 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	16	19,565,417 - 19,566,718 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	16	20,703,631 - 20,704,932 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	16	19,618,400 - 19,619,701 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	16	21,272,282 - 21,274,756 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	16	21,273,387 - 21,274,688 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	16	21,189,471 - 21,190,772 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	16	20,009,499 - 20,010,800 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
Celera	16	19,713,817 - 19,715,118 (-)	NCBI		Celera
Cytogenetic Map	16	p14	NCBI

Tssk6
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955524	2,433,955 - 2,434,776 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955524	2,433,855 - 2,434,864 (+)	NCBI	ChiLan1.0	ChiLan1.0

TSSK6
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	20	24,368,803 - 24,377,963 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	19	23,376,046 - 23,384,379 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	19	18,952,643 - 18,954,101 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	19	19,948,494 - 19,951,687 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	19	19,950,614 - 19,951,435 (-)	Ensembl	panpan1.1		panPan2

TSSK6
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	20	43,730,769 - 43,732,179 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	20	43,730,907 - 43,731,728 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	20	43,648,310 - 43,649,731 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	20	44,218,731 - 44,220,145 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	20	44,218,873 - 44,219,694 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	20	43,456,322 - 43,457,736 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	20	43,865,730 - 43,867,144 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	20	44,141,362 - 44,142,783 (+)	NCBI		UU_Cfam_GSD_1.0

Tssk6
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405118	202,405,185 - 202,406,630 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936596	1,954,517 - 1,955,338 (+)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936596	1,953,797 - 1,955,753 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

TSSK6
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	2	58,411,122 - 58,411,943 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	2	58,411,122 - 58,411,943 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	2	58,286,057 - 58,286,878 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

TSSK6
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	6	17,974,174 - 17,975,996 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	6	17,974,913 - 17,975,734 (-)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666074	1,325,901 - 1,327,361 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Tssk6
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624908	2,310,872 - 2,311,693 (-)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624908	2,310,456 - 2,311,803 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in TSSK6
4 total Variants

Clinical Variants

Name	Type	Condition(s)	Position(s)	Clinical significance
GRCh38/hg38 19p13.11-q13.11(chr19:17176767-34924150)x3	copy number gain	See cases [RCV000050635]	Chr19:17176767..34924150 [GRCh38] Chr19:17287576..35415054 [GRCh37] Chr19:17148576..40106894 [NCBI36] Chr19:19p13.11-q13.11	pathogenic
GRCh38/hg38 19p13.12-q11(chr19:13974677-27839676)x3	copy number gain	See cases [RCV000052912]	Chr19:13974677..27839676 [GRCh38] Chr19:14085489..28330584 [GRCh37] Chr19:13946489..33022424 [NCBI36] Chr19:19p13.12-q11	pathogenic
GRCh38/hg38 19p13.2-q13.31(chr19:11227942-44626354)x3	copy number gain	See cases [RCV000133888]	Chr19:11227942..44626354 [GRCh38] Chr19:11338618..45129651 [GRCh37] Chr19:11199618..49821491 [NCBI36] Chr19:19p13.2-q13.31	pathogenic
GRCh38/hg38 19p13.12-12(chr19:15133594-24193591)x3	copy number gain	See cases [RCV000136696]	Chr19:15133594..24193591 [GRCh38] Chr19:15244405..24376393 [GRCh37] Chr19:15105405..24168233 [NCBI36] Chr19:19p13.12-12	pathogenic\|likely pathogenic
chr19:19230868-24115369 complex variant	complex	Breast ductal adenocarcinoma [RCV000207223]	Chr19:19230868..24115369 [GRCh37] Chr19:19p13.11-12	uncertain significance
GRCh37/hg19 19p13.11-11(chr19:16526787-24631604)x3	copy number gain	not provided [RCV000752593]	Chr19:16526787..24631604 [GRCh37] Chr19:19p13.11-11	pathogenic
GRCh37/hg19 19p13.3-q13.43(chr19:260912-58956888)x3	copy number gain	See cases [RCV000511289]	Chr19:260912..58956888 [GRCh37] Chr19:19p13.3-q13.43	pathogenic\|uncertain significance
GRCh37/hg19 19p13.3-q13.43(chr19:260912-58956888)	copy number gain	See cases [RCV000512296]	Chr19:260912..58956888 [GRCh37] Chr19:19p13.3-q13.43	pathogenic
GRCh37/hg19 19p13.3-q13.43(chr19:260912-59097160)x3	copy number gain	not provided [RCV000752444]	Chr19:260912..59097160 [GRCh37] Chr19:19p13.3-q13.43	pathogenic
GRCh37/hg19 19p13.3-q13.43(chr19:68029-59110290)x3	copy number gain	not provided [RCV000752439]	Chr19:68029..59110290 [GRCh37] Chr19:19p13.3-q13.43	pathogenic
GRCh37/hg19 19p13.11(chr19:19560981-19962412)x3	copy number gain	not provided [RCV000849580]	Chr19:19560981..19962412 [GRCh37] Chr19:19p13.11	uncertain significance
GRCh37/hg19 19p13.12-12(chr19:14286624-20956753)x3	copy number gain	not provided [RCV001259370]	Chr19:14286624..20956753 [GRCh37] Chr19:19p13.12-12	pathogenic
GRCh37/hg19 19p13.11-q13.2(chr19:19546923-41313229)x3	copy number gain	Specific learning disability [RCV001801194]	Chr19:19546923..41313229 [GRCh37] Chr19:19p13.11-q13.2	pathogenic
NM_032037.4(TSSK6):c.434C>G (p.Pro145Arg)	single nucleotide variant	Inborn genetic diseases [RCV002956273]	Chr19:19514994 [GRCh38] Chr19:19625803 [GRCh37] Chr19:19p13.11	uncertain significance
NM_032037.4(TSSK6):c.679G>A (p.Gly227Ser)	single nucleotide variant	Inborn genetic diseases [RCV003180291]	Chr19:19514749 [GRCh38] Chr19:19625558 [GRCh37] Chr19:19p13.11	uncertain significance
NM_032037.4(TSSK6):c.736G>A (p.Glu246Lys)	single nucleotide variant	Inborn genetic diseases [RCV003201027]	Chr19:19514692 [GRCh38] Chr19:19625501 [GRCh37] Chr19:19p13.11	uncertain significance
NM_032037.4(TSSK6):c.606C>T (p.Leu202=)	single nucleotide variant	not provided [RCV003415161]	Chr19:19514822 [GRCh38] Chr19:19625631 [GRCh37] Chr19:19p13.11	likely benign
GRCh37/hg19 19p13.11-12(chr19:18926463-21100330)x1	copy number loss	not specified [RCV003986109]	Chr19:18926463..21100330 [GRCh37] Chr19:19p13.11-12	uncertain significance

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	1705
Count of miRNA genes:	525
Interacting mature miRNAs:	610
Transcripts:	ENST00000360913, ENST00000585580, ENST00000587522, ENST00000602623
Prediction methods:	Microtar, Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

Markers in Region

TSSK6

Human Assembly	Chr	Position (strand)	Source	JBrowse
GRCh37	19	19,625,619 - 19,625,788	UniSTS	GRCh37
Celera	19	19,529,678 - 19,529,847	UniSTS
HuRef	19	19,187,912 - 19,188,081	UniSTS

Expression

RNA-SEQ Expression

High: > 1000 TPM value Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system

circulatory system

endocrine system

exocrine system

hemolymphoid system

hepatobiliary system

integumental system

musculoskeletal system

nervous system

renal system

reproductive system

respiratory system

sensory system

adipose tissue

appendage

entire extraembryonic component

High

Medium

415

Low

2360

2167

1645

570

1710

413

3749

1259

3375

408

1013

1513

169

1089

2204

Below cutoff

816

214

593

919

329

114

574

View RNA-SEQ Expression Data

Sequence

Nucleotide Sequences


RefSeq Transcripts	NG_013380	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	NG_033078	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	NM_032037	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AA608857	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AC011448	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AF329483	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AF348077	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AK058166	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AK172841	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AK313767	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BC014611	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH471106	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CP068259	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	HM005618	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

ENST00000585580 ⟹ ENSP00000466477

Type:

CODING

Position:

Human Assembly	Chr	Position (strand)	Source
GRCh38.p14 Ensembl	19	19,514,219 - 19,515,548 (-)	Ensembl

RefSeq Acc Id:

ENST00000587522 ⟹ ENSP00000466056

Type:

CODING

Position:

Human Assembly	Chr	Position (strand)	Source
GRCh38.p14 Ensembl	19	19,512,418 - 19,515,548 (-)	Ensembl

RefSeq Acc Id:

ENST00000602623 ⟹ ENSP00000473413

Type:

CODING

Position:

Human Assembly	Chr	Position (strand)	Source
GRCh38.p14 Ensembl	19	19,512,456 - 19,514,935 (-)	Ensembl

RefSeq Acc Id:

NM_032037 ⟹ NP_114426

RefSeq Status:

REVIEWED

Type:

CODING

Position:

Human Assembly	Chr	Position (strand)	Source
GRCh38	19	19,514,219 - 19,515,548 (-)	NCBI
GRCh37	19	19,625,028 - 19,626,469 (-)	RGD
Build 36	19	19,486,028 - 19,487,469 (-)	NCBI Archive
Celera	19	19,529,087 - 19,530,528 (-)	RGD
HuRef	19	19,187,321 - 19,188,762 (-)	RGD
CHM1_1	19	19,625,724 - 19,627,165 (-)	NCBI
T2T-CHM13v2.0	19	19,651,706 - 19,653,035 (-)	NCBI

Sequence:

show sequence

AGTGGGCACATGGGGGTGCGGGGGTGTAGGTGCCAAGCGCCATGGCTTAGACCCGAGATTGGAG
TCCGGCCGCCCCCCGACAGCAGCCGCCTCCTGCCCCCCGTGCGCCCTAGGCGCCACCATGTCGG
GAGACAAACTTCTGAGCGAACTCGGTTATAAGCTGGGCCGCACAATTGGAGAGGGCAGCTACTC
CAAGGTGAAGGTGGCCACATCCAAGAAGTACAAGGGTACCGTGGCCATCAAGGTGGTGGACCGG
CGGCGAGCGCCCCCGGACTTCGTCAACAAGTTCCTGCCGCGAGAGCTGTCCATCCTGCGGGGCG
TGCGACACCCGCACATCGTGCACGTCTTCGAGTTCATCGAGGTGTGCAACGGGAAACTGTACAT
CGTGATGGAAGCGGCCGCCACCGACCTGCTGCAAGCCGTGCAGCGCAACGGGCGCATCCCCGGA
GTTCAGGCGCGCGACCTCTTTGCGCAGATCGCCGGCGCCGTGCGCTACCTGCACGATCATCACC
TGGTGCACCGCGACCTCAAGTGCGAAAACGTGCTGCTGAGCCCGGACGAGCGCCGCGTCAAGCT
CACCGACTTCGGCTTCGGCCGCCAGGCCCATGGCTACCCAGACCTGAGCACCACCTACTGCGGC
TCAGCCGCCTACGCGTCACCCGAGGTGCTCCTGGGCATCCCCTACGACCCCAAGAAGTACGATG
TGTGGAGCATGGGCGTCGTGCTCTACGTCATGGTCACCGGGTGCATGCCCTTCGACGACTCGGA
CATCGCCGGCCTGCCCCGGCGCCAGAAACGCGGCGTGCTCTATCCCGAAGGCCTCGAGCTGTCC
GAGCGCTGCAAGGCCCTGATCGCCGAGCTGCTGCAGTTCAGCCCGTCCGCCAGGCCCTCCGCGG
GCCAGGTAGCGCGCAACTGCTGGCTGCGCGCCGGGGACTCCGGCTAGAAGCCGGGTGGTTCCAG
CCATTCCTGCAGCCAAGGGCACTGGGCCAGGGCGGCGCACGCGCAAGAGGCGCGCTTCGAGGGA
ATATGCGAAGCTGCCGCGTGCTGCTGCACATGCGCTTTTTCCCTTCCGCTTCCCTCCCTTTCTT
CCCACGGGGGAGTCCGCAGTTGCCCTTGTTCGGAATCCACGTTCCCCGCGATCCCGGGAGCTGG
AGGCGCATGCGCATCCGCGATTCCCTGCGACCAGGCCCCGAGAGGGCGAGACCAGAGGGGACGG
AAGCATTGCGCCTGCGCGGAACTCTCAGCCTCTGCGCGGAGGGCGTCCCTTCCCAACCAGCCGT
GGGTGCCAGGTTCCCGGTTGGAACCTGCAATAAACTCGCTGTTCCTCGCA

hide sequence

Protein Sequences


Protein RefSeqs	NP_114426	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAH14611	(Get FASTA)	NCBI Sequence Viewer
	AAK29414	(Get FASTA)	NCBI Sequence Viewer
	AAK48827	(Get FASTA)	NCBI Sequence Viewer
	AEE61215	(Get FASTA)	NCBI Sequence Viewer
	BAB71697	(Get FASTA)	NCBI Sequence Viewer
	BAD18805	(Get FASTA)	NCBI Sequence Viewer
	BAG36505	(Get FASTA)	NCBI Sequence Viewer
	EAW84824	(Get FASTA)	NCBI Sequence Viewer
	EAW84825	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSP00000466056.1
	ENSP00000466477
	ENSP00000466477.1
	ENSP00000473413.1
GenBank Protein	Q9BXA6	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:

NP_114426 ⟸ NM_032037

- UniProtKB:

Q6ZMC4 (UniProtKB/Swiss-Prot), B2R9F8 (UniProtKB/Swiss-Prot), Q96LJ4 (UniProtKB/Swiss-Prot), Q9BXA6 (UniProtKB/Swiss-Prot), A0A024R7Q5 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MSGDKLLSELGYKLGRTIGEGSYSKVKVATSKKYKGTVAIKVVDRRRAPPDFVNKFLPRELSIL
RGVRHPHIVHVFEFIEVCNGKLYIVMEAAATDLLQAVQRNGRIPGVQARDLFAQIAGAVRYLHD
HHLVHRDLKCENVLLSPDERRVKLTDFGFGRQAHGYPDLSTTYCGSAAYASPEVLLGIPYDPKK
YDVWSMGVVLYVMVTGCMPFDDSDIAGLPRRQKRGVLYPEGLELSERCKALIAELLQFSPSARP
SAGQVARNCWLRAGDSG

hide sequence

RefSeq Acc Id:

ENSP00000466477 ⟸ ENST00000585580

RefSeq Acc Id:

ENSP00000466056 ⟸ ENST00000587522

RefSeq Acc Id:

ENSP00000473413 ⟸ ENST00000602623

Protein Domains

Protein kinase

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-Q9BXA6-F1-model_v2	AlphaFold	Q9BXA6	1-273	view protein structure

Promoters

RGD ID:

6795842

Promoter ID:

HG_KWN:29367

Type:

CpG-Island

SO ACC ID:

SO:0000170

Source:

MPROMDB

Tissues & Cell Lines:

CD4+TCell, CD4+TCell_12Hour, CD4+TCell_2Hour, HeLa_S3, Jurkat, K562, Lymphoblastoid, NB4

Transcripts:

ENST00000360913, UC002NMS.2

Position:

Human Assembly	Chr	Position (strand)	Source
Build 36	19	19,487,731 - 19,488,231 (+)	MPROMDB

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	HGNC:30410	AgrOrtholog
COSMIC	TSSK6	COSMIC
Ensembl Genes	ENSG00000178093	Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript	ENST00000585580	ENTREZGENE
	ENST00000585580.4	UniProtKB/Swiss-Prot
	ENST00000587522.3	UniProtKB/Swiss-Prot
	ENST00000602623.1	UniProtKB/TrEMBL
Gene3D-CATH	Transferase(Phosphotransferase) domain 1	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
GTEx	ENSG00000178093	GTEx
HGNC ID	HGNC:30410	ENTREZGENE
Human Proteome Map	TSSK6	Human Proteome Map
InterPro	Kinase-like_dom_sf	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Prot_kinase_dom	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Protein_kinase_ATP_BS	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Ser/Thr_kinase_AS	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	TSSK6_STKc	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report	hsa:83983	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene	83983	ENTREZGENE
OMIM	610712	OMIM
PANTHER	MAP/MICROTUBULE AFFINITY-REGULATING KINASE	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	TESTIS-SPECIFIC SERINE_THREONINE-PROTEIN KINASE 1	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam	Pkinase	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB	PA142670682	PharmGKB
PIRSF	Integrin-linked_kinase	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE	PROTEIN_KINASE_ATP	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	PROTEIN_KINASE_DOM	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	PROTEIN_KINASE_ST	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART	S_TKc	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP	SSF56112	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt	A0A024R7Q5	ENTREZGENE, UniProtKB/TrEMBL
	B2R9F8	ENTREZGENE
	Q6ZMC4	ENTREZGENE
	Q96LJ4	ENTREZGENE
	Q9BXA6	ENTREZGENE
	R4GMZ2_HUMAN	UniProtKB/TrEMBL
	TSSK6_HUMAN	UniProtKB/Swiss-Prot
UniProt Secondary	B2R9F8	UniProtKB/Swiss-Prot
	Q6ZMC4	UniProtKB/Swiss-Prot
	Q96LJ4	UniProtKB/Swiss-Prot

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2016-02-02	TSSK6	testis specific serine kinase 6		testis-specific serine kinase 6	Symbol and/or name change	5135510	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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Imported Disease Annotations - ClinVar