| 1306607 | Trip12 | thyroid hormone receptor interactor 12 | ENCODES a protein that exhibits nuclear thyroid hormone receptor binding (ortholog); ubiquitin protein ligase activity (ortholog); INVOLVED IN DNA repair-dependent chromatin remodeling (ortholog); heterochromatin boundary formation (ortholog); protein polyubiquitination (ortholog); PARTICIPATES IN a taxia telangiectasia-mutated (ATM) signaling pathway; ubiquitin/proteasome degradation pathway; ASSOCIATED WITH Clark-Baraitser syndrome (ortholog); Developmental Disease (ortholog); genetic disease (ortholog); FOUND IN nucleoplasm (ortholog); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,4-dinitrotoluene; 2,6-dinitrotoluene | 9 | 93364791 | 93491015 | Rat | 148 | symbol , old_gene_name , PhenoGen | gene, protein-coding, VALIDATED [RefSeq] |
| 1315318 | TRIP12 | thyroid hormone receptor interactor 12 | The protein encoded by this gene is an E3 ubiquitin-protein ligase involved in the degradation of the p19ARF/ARF isoform of CDKN2A, a tumor suppressor. The encoded protein also plays a role in the DNA damage response by regulating the stability of USP7, which regulates tumor suppressor p53. [provide d by RefSeq, Jan 2017] | 2 | 229763837 | 229923186 | Human | 208 | symbol , old_gene_name , COSMIC , Human Proteome Map | gene, protein-coding, REVIEWED [RefSeq] |
| 1315319 | Trip12 | thyroid hormone receptor interactor 12 | Predicted to enable nuclear thyroid hormone receptor binding activity and ubiquitin protein ligase activity. Involved in regulation of embryonic development. Predicted to be located in nucleoplasm. Predicted to be active in nuclear speck. Is expressed in several structures, including brain and genit ourinary system. Human ortholog(s) of this gene implicated in Clark-Baraitser syndrome. Orthologous to human TRIP12 (thyroid hormone receptor interactor 12). [provided by Alliance of Genome Resources, Jul 2025] | 1 | 84698910 | 84818285 | Mouse | 154 | symbol , old_gene_name , PhenoGen , description | gene, protein-coding, VALIDATED [RefSeq] |
| 8766720 | Trip12 | thyroid hormone receptor interactor 12 | ENCODES a protein that exhibits nuclear thyroid hormone receptor binding (ortholog); ubiquitin protein ligase activity (ortholog); INVOLVED IN DNA repair-dependent chromatin remodeling (ortholog); heterochromatin boundary formation (ortholog); protein polyubiquitination (ortholog); PARTICIPATES IN a taxia telangiectasia-mutated (ATM) signaling pathway; ASSOCIATED WITH Clark-Baraitser syndrome (ortholog); Developmental Disease (ortholog); genetic disease (ortholog); FOUND IN nucleoplasm (ortholog) | NW_004955453 | 5132776 | 5272250 | Chinchilla | 24 | symbol , old_gene_name | gene, protein-coding, MODEL [RefSeq] |
| 11760661 | TRIP12 | thyroid hormone receptor interactor 12 | ENCODES a protein that exhibits nuclear thyroid hormone receptor binding (ortholog); INVOLVED IN DNA repair-dependent chromatin remodeling (ortholog); heterochromatin boundary formation (ortholog); PARTICIPATES IN ataxia telangiectasia-mutated (ATM) signaling pathway; ASSOCIATED WITH Clark-Baraitser syndrome (ortholog); Developmental Disease (ortholog); genetic disease (ortholog); FOUND IN nuclear speck (inferred); nucleoplasm (inferred); nucleus (inferred) | 2B | 117013343 | 117175296 | Bonobo | 36 | symbol , old_gene_name | gene, protein-coding, MODEL [RefSeq] |
| 12432550 | TRIP12 | thyroid hormone receptor interactor 12 | ENCODES a protein that exhibits nuclear thyroid hormone receptor binding (ortholog); INVOLVED IN DNA repair-dependent chromatin remodeling (ortholog); heterochromatin boundary formation (ortholog); PARTICIPATES IN ataxia telangiectasia-mutated (ATM) signaling pathway; ASSOCIATED WITH Clark-Baraitser syndrome (ortholog); Developmental Disease (ortholog); genetic disease (ortholog); FOUND IN nucleoplasm (inferred); nucleus (inferred) | 25 | 42060103 | 42208326 | Dog | 36 | symbol , old_gene_name | gene, protein-coding, MODEL [RefSeq] |
| 12626298 | Trip12 | thyroid hormone receptor interactor 12 | ENCODES a protein that exhibits nuclear thyroid hormone receptor binding (ortholog); INVOLVED IN DNA repair-dependent chromatin remodeling (ortholog); heterochromatin boundary formation (ortholog); PARTICIPATES IN ataxia telangiectasia-mutated (ATM) signaling pathway; ASSOCIATED WITH Clark-Baraitser syndrome (ortholog); Developmental Disease (ortholog); genetic disease (ortholog); FOUND IN nuclear speck (inferred); nucleoplasm (inferred); nucleus (inferred) | NW_004936525 | 6539234 | 6690457 | Squirrel | 36 | symbol , old_gene_name | gene, protein-coding, MODEL [RefSeq] |
| 626132260 | Trip12 | thyroid hormone receptor interactor 12 | ENCODES a protein that exhibits nuclear thyroid hormone receptor binding (ortholog); ubiquitin protein ligase activity (ortholog); INVOLVED IN DNA repair-dependent chromatin remodeling (ortholog); heterochromatin boundary formation (ortholog); protein polyubiquitination (ortholog); PARTICIPATES IN a taxia telangiectasia-mutated (ATM) signaling pathway; ASSOCIATED WITH Clark-Baraitser syndrome (ortholog); Developmental Disease (ortholog); genetic disease (ortholog); FOUND IN nucleoplasm (ortholog) | | | | Black Rat | 23 | symbol , old_gene_name | gene, protein-coding, MODEL [RefSeq] |
| 18665107 | TRIP12 | thyroid hormone receptor interactor 12 | ENCODES a protein that exhibits nuclear thyroid hormone receptor binding (ortholog); INVOLVED IN DNA repair-dependent chromatin remodeling (ortholog); heterochromatin boundary formation (ortholog); PARTICIPATES IN ataxia telangiectasia-mutated (ATM) signaling pathway; ASSOCIATED WITH Clark-Baraitser syndrome (ortholog); Developmental Disease (ortholog); genetic disease (ortholog); FOUND IN nuclear speck (inferred); nucleoplasm (inferred); nucleus (inferred) | | | | Green Monkey | 36 | symbol , old_gene_name | gene, protein-coding, MODEL [RefSeq] |
| 18919018 | Trip12 | thyroid hormone receptor interactor 12 | ENCODES a protein that exhibits nuclear thyroid hormone receptor binding (ortholog); INVOLVED IN DNA repair-dependent chromatin remodeling (ortholog); heterochromatin boundary formation (ortholog); regulation of embryonic development (ortholog); PARTICIPATES IN ataxia telangiectasia-mutated (ATM) si gnaling pathway; ASSOCIATED WITH Clark-Baraitser syndrome (ortholog); Developmental Disease (ortholog); genetic disease (ortholog); FOUND IN nuclear speck (inferred); nucleoplasm (inferred); nucleus (inferred) | | | | Naked Mole-Rat | 36 | symbol , old_gene_name | gene, protein-coding, MODEL [RefSeq] |
| 155253846 | trip12 | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 14000586 | TRIP12 | thyroid hormone receptor interactor 12 | ENCODES a protein that exhibits nuclear thyroid hormone receptor binding (ortholog); INVOLVED IN DNA repair-dependent chromatin remodeling (ortholog); heterochromatin boundary formation (ortholog); PARTICIPATES IN ataxia telangiectasia-mutated (ATM) signaling pathway; ASSOCIATED WITH Clark-Baraitser syndrome (ortholog); Developmental Disease (ortholog); genetic disease (ortholog); FOUND IN nucleoplasm (inferred); nucleus (inferred) | | | | Pig | 36 | symbol , old_gene_name | gene, protein-coding, MODEL [RefSeq] |
| 155235705 | trip12.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 155256852 | trip12.S | | | | | | African Clawed Frog | | symbol | gene, null |
| 18914070 | LOC101719769 | E3 ubiquitin-protein ligase TRIP12-like | | | | | Naked Mole-Rat | | name | gene, pseudo, MODEL [RefSeq] |
| 18930599 | LOC110343854 | E3 ubiquitin-protein ligase TRIP12-like | | | | | Naked Mole-Rat | | name | gene, pseudo, MODEL [RefSeq] |
| 18900398 | LOC110343862 | E3 ubiquitin-protein ligase TRIP12-like | | | | | Naked Mole-Rat | | name | gene, pseudo, MODEL [RefSeq] |
| 39128499 | Gm50613 | predicted gene, 50613 | | 17 | 8785877 | 8787783 | Mouse | | old_gene_name | gene, pseudo, MODEL [RefSeq] |