| 619964 | Trim63 | tripartite motif containing 63 | ENCODES a protein that exhibits ubiquitin-protein transferase activity; titin binding (ortholog); ubiquitin protein ligase activity (ortholog); INVOLVED IN muscle contraction; negative regulation of cardiac muscle hypertrophy; response to electrical stimulus involved in regulation of muscle adaptati on; ASSOCIATED WITH muscular atrophy; muscular dystrophy; Atrophy (ortholog); FOUND IN contractile muscle fiber; Cul4-RING E3 ubiquitin ligase complex (ortholog); cytoplasm (ortholog); INTERACTS WITH 17alpha-ethynylestradiol; 17beta-estradiol; 17beta-estradiol 3-benzoate | 5 | 151817209 | 151831026 | Rat | 167 | symbol , old_gene_name , PhenoGen | gene, protein-coding, VALIDATED [RefSeq] |
| 1345707 | TRIM63 | tripartite motif containing 63 | This gene encodes a member of the RING zinc finger protein family found in striated muscle and iris. The product of this gene is an E3 ubiquitin ligase that localizes to the Z-line and M-line lattices of myofibrils. This protein plays an important role in the atrophy of skeletal and cardiac muscle a nd is required for the degradation of myosin heavy chain proteins, myosin light chain, myosin binding protein, and for muscle-type creatine kinase. [provided by RefSeq, Feb 2012] | 1 | 26051301 | 26067630 | Human | 198 | symbol , old_gene_name , COSMIC , Human Proteome Map | gene, protein-coding, REVIEWED [RefSeq] |
| 1617155 | Trim63 | tripartite motif-containing 63 | Enables ubiquitin protein ligase activity. Involved in protein monoubiquitination and response to denervation involved in regulation of muscle adaptation. Acts upstream of or within several processes, including cellular response to dexamethasone stimulus; myotube cell development; and proteasome-med iated ubiquitin-dependent protein catabolic process. Part of Cul4-RING E3 ubiquitin ligase complex. Is expressed in embryo and heart. Orthologous to human TRIM63 (tripartite motif containing 63). [provided by Alliance of Genome Resources, Jul 2025] | 4 | 134042431 | 134056940 | Mouse | 199 | symbol , old_gene_name , PhenoGen , description | gene, protein-coding, VALIDATED [RefSeq] |
| 8752356 | Trim63 | tripartite motif containing 63 | ENCODES a protein that exhibits titin binding (ortholog); ubiquitin protein ligase activity (ortholog); ubiquitin-protein transferase activity (ortholog); INVOLVED IN cellular response to dexamethasone stimulus (ortholog); muscle contraction (ortholog); myotube cell development (ortholog); ASSOCIATE D WITH Atrophy (ortholog); Cardiomegaly (ortholog); cardiomyopathy (ortholog); FOUND IN contractile muscle fiber (ortholog); Cul4-RING E3 ubiquitin ligase complex (ortholog); cytoplasm (ortholog) | NW_004955452 | 5517969 | 5531490 | Chinchilla | 42 | symbol , old_gene_name | gene, protein-coding, MODEL [RefSeq] |
| 11928032 | TRIM63 | tripartite motif containing 63 | ENCODES a protein that exhibits ubiquitin-protein transferase activity (ortholog); INVOLVED IN cellular response to dexamethasone stimulus (ortholog); muscle contraction (ortholog); myotube cell development (ortholog); ASSOCIATED WITH Atrophy (ortholog); Cardiomegaly (ortholog); cardiomyopathy (orth olog); FOUND IN contractile muscle fiber (ortholog); Cul4-RING E3 ubiquitin ligase complex (ortholog) | 1 | 25309949 | 25373658 | Bonobo | 50 | symbol , old_gene_name | gene, protein-coding, MODEL [RefSeq] |
| 12274482 | TRIM63 | tripartite motif containing 63 | ENCODES a protein that exhibits ubiquitin-protein transferase activity (ortholog); INVOLVED IN cellular response to dexamethasone stimulus (ortholog); muscle contraction (ortholog); myotube cell development (ortholog); ASSOCIATED WITH Atrophy (ortholog); Cardiomegaly (ortholog); cardiomyopathy (orth olog); FOUND IN contractile muscle fiber (ortholog); Cul4-RING E3 ubiquitin ligase complex (ortholog); INTERACTS WITH bisphenol A | 2 | 73841868 | 73918371 | Dog | 52 | symbol , old_gene_name | gene, protein-coding, MODEL [RefSeq] |
| 12489171 | Trim63 | tripartite motif containing 63 | ENCODES a protein that exhibits ubiquitin-protein transferase activity (ortholog); INVOLVED IN cellular response to dexamethasone stimulus (ortholog); muscle contraction (ortholog); myotube cell development (ortholog); ASSOCIATED WITH Atrophy (ortholog); Cardiomegaly (ortholog); cardiomyopathy (orth olog); FOUND IN contractile muscle fiber (ortholog); Cul4-RING E3 ubiquitin ligase complex (ortholog) | NW_004936474 | 10598571 | 10610197 | Squirrel | 49 | symbol , old_gene_name | gene, protein-coding, MODEL [RefSeq] |
| 18922784 | Trim63 | tripartite motif containing 63 | ENCODES a protein that exhibits titin binding (ortholog); ubiquitin-protein transferase activity (ortholog); INVOLVED IN cellular response to dexamethasone stimulus (ortholog); muscle contraction (ortholog); myotube cell development (ortholog); ASSOCIATED WITH Atrophy (ortholog); Cardiomegaly (ortho log); cardiomyopathy (ortholog); FOUND IN contractile muscle fiber (ortholog); Cul4-RING E3 ubiquitin ligase complex (ortholog); M band (ortholog) | | | | Naked Mole-Rat | 47 | symbol , old_gene_name | gene, protein-coding, MODEL [RefSeq] |
| 14027302 | TRIM63 | tripartite motif containing 63 | ENCODES a protein that exhibits ubiquitin-protein transferase activity (ortholog); INVOLVED IN cellular response to dexamethasone stimulus (ortholog); muscle contraction (ortholog); myotube cell development (ortholog); ASSOCIATED WITH Atrophy (ortholog); Cardiomegaly (ortholog); cardiomyopathy (orth olog); FOUND IN contractile muscle fiber (ortholog); Cul4-RING E3 ubiquitin ligase complex (ortholog) | | | | Pig | 50 | symbol , old_gene_name | gene, protein-coding, PROVISIONAL [RefSeq] |
| 625851554 | Trim63 | tripartite motif containing 63 | ENCODES a protein that exhibits titin binding (ortholog); ubiquitin protein ligase activity (ortholog); ubiquitin-protein transferase activity (ortholog); INVOLVED IN cellular response to dexamethasone stimulus (ortholog); muscle contraction (ortholog); myotube cell development (ortholog); ASSOCIATE D WITH Atrophy (ortholog); Cardiomegaly (ortholog); cardiomyopathy (ortholog); FOUND IN contractile muscle fiber (ortholog); Cul4-RING E3 ubiquitin ligase complex (ortholog); cytoplasm (ortholog) | | | | Black Rat | 42 | symbol , old_gene_name | gene, protein-coding, MODEL [RefSeq] |
| 155236900 | trim63 | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 18366609 | TRIM63 | tripartite motif containing 63 | ENCODES a protein that exhibits ubiquitin-protein transferase activity (ortholog); INVOLVED IN cellular response to dexamethasone stimulus (ortholog); muscle contraction (ortholog); myotube cell development (ortholog); ASSOCIATED WITH Atrophy (ortholog); Cardiomegaly (ortholog); cardiomyopathy (orth olog); FOUND IN contractile muscle fiber (ortholog); Cul4-RING E3 ubiquitin ligase complex (ortholog) | | | | Green Monkey | 50 | symbol , old_gene_name | gene, protein-coding, MODEL [RefSeq] |
| 155239459 | trim63.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 155257036 | trim63.S | | | | | | African Clawed Frog | | symbol | gene, null |
| 14696789 | Trim63em1(hiLuc) | tripartite motif containing 63; ZFN targeted mutation 1 | ASSOCIATED WITH muscular dystrophy | | | | Rat | 1 | symbol , description | gene, allele |