Trim63 (tripartite motif containing 63)

Advanced Search (OLGA)

Gene: Trim63 (tripartite motif containing 63) Chinchilla lanigera

Analyze

Symbol:

Trim63

Name:

tripartite motif containing 63

RGD ID:

8752356

Description:

ENCODES a protein that exhibits titin binding (ortholog); ubiquitin protein ligase activity (ortholog); ubiquitin-protein transferase activity (ortholog); INVOLVED IN cellular response to dexamethasone stimulus (ortholog); muscle contraction (ortholog); negative regulation of cardiac muscle hypertrophy (ortholog); ASSOCIATED WITH Atrophy (ortholog); autosomal recessive hypercholesterolemia (ortholog); Cardiomegaly (ortholog); FOUND IN contractile muscle fiber (ortholog); cytoplasm (ortholog)

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

E3 ubiquitin-protein ligase TRIM63; tripartite motif containing 63, E3 ubiquitin protein ligase

RGD Orthologs

Alliance Orthologs

More Info

more info ...

Latest Assembly:

ChiLan1.0 - Chinchilla ChiLan1.0 Assembly

Position:

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955452	5,520,269 - 5,531,975 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955452	5,517,969 - 5,531,490 (-)	NCBI	ChiLan1.0	ChiLan1.0

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

Atrophy (ISO)

autosomal recessive hypercholesterolemia (ISO)

Cardiomegaly (ISO)

cardiomyopathy (ISO)

familial hypertrophic cardiomyopathy (ISO)

genetic disease (ISO)

hypertrophic cardiomyopathy (ISO)

muscular atrophy (ISO)

muscular dystrophy (ISO)

primary pulmonary hypertension (ISO)

retinitis pigmentosa 59 (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

cellular response to dexamethasone stimulus (ISO)

muscle contraction (ISO)

negative regulation of cardiac muscle hypertrophy (ISO)

negative regulation of glycolytic process (ISO)

proteasome-mediated ubiquitin-dependent protein catabolic process (ISO)

protein monoubiquitination (ISO)

regulation of gene expression (ISO)

response to denervation involved in regulation of muscle adaptation (ISO)

response to electrical stimulus involved in regulation of muscle adaptation (ISO)

response to glucocorticoid (ISO)

response to interleukin-1 (ISO)

skeletal muscle atrophy (ISO)

Cellular Component

contractile muscle fiber (ISO)

cytoplasm (ISO)

Molecular Function

protein binding (ISO)

titin binding (ISO)

ubiquitin protein ligase activity (ISO)

ubiquitin-protein transferase activity (ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	Transitive Annotation Pipeline	Automated assignment of GO, PW and RDO ISO annotations across species

Additional References at PubMed

PMID:22301074

Genomics

Comparative Map Data

Trim63
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955452	5,520,269 - 5,531,975 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955452	5,517,969 - 5,531,490 (-)	NCBI	ChiLan1.0	ChiLan1.0

TRIM63
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	1	26,051,301 - 26,067,630 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	1	26,051,301 - 26,068,436 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	1	26,377,792 - 26,394,121 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	1	26,250,385 - 26,266,708 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	1	26,061,939 - 26,078,263	NCBI
Celera	1	24,774,477 - 24,790,800 (-)	NCBI		Celera
Cytogenetic Map	1	p36.11	NCBI
HuRef	1	24,631,910 - 24,648,243 (-)	NCBI		HuRef
CHM1_1	1	26,491,024 - 26,507,354 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	1	25,888,705 - 25,905,036 (-)	NCBI		T2T-CHM13v2.0

Trim63
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	4	134,042,431 - 134,056,940 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	4	134,042,431 - 134,056,940 (+)	Ensembl		GRCm39 Ensembl
GRCm38	4	134,315,120 - 134,329,629 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	4	134,315,120 - 134,329,629 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	4	133,871,035 - 133,885,544 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	4	133,587,300 - 133,599,849 (+)	NCBI		MGSCv36	mm8
MGSCv36	4	131,890,695 - 131,903,401 (+)	NCBI		MGSCv36	mm8
Celera	4	132,494,119 - 132,532,748 (+)	NCBI		Celera
Cytogenetic Map	4	D2.3	NCBI
cM Map	4	66.58	NCBI

Trim63
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	5	151,817,209 - 151,831,026 (+)	NCBI		GRCr8
mRatBN7.2	5	146,533,492 - 146,547,332 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	5	146,533,507 - 146,547,322 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	5	149,235,082 - 149,248,910 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	5	151,005,655 - 151,019,448 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	5	150,991,304 - 151,005,134 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	5	152,533,362 - 152,547,138 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	5	152,533,349 - 152,547,179 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	5	156,292,566 - 156,306,092 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	5	153,059,573 - 153,073,907 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	5	153,069,611 - 153,083,946 (+)	NCBI
Celera	5	144,951,021 - 144,964,729 (+)	NCBI		Celera
Cytogenetic Map	5	q36	NCBI

TRIM63
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	1	200,803,361 - 200,822,764 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	1	199,901,170 - 199,921,975 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	1	25,309,949 - 25,373,658 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	1	26,375,950 - 26,392,181 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	1	26,378,373 - 26,392,041 (-)	Ensembl	panpan1.1		panPan2

TRIM63
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	2	73,841,868 - 73,918,371 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	2	73,888,689 - 73,909,414 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	2	70,438,074 - 70,494,650 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	2	74,424,585 - 74,481,266 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	2	74,459,986 - 74,472,864 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	2	71,248,854 - 71,304,886 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	2	72,254,742 - 72,311,207 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	2	73,258,494 - 73,315,066 (+)	NCBI		UU_Cfam_GSD_1.0

Trim63
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405058	44,773,779 - 44,810,443 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936474	10,598,561 - 10,633,001 (-)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936474	10,598,571 - 10,610,197 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

TRIM63
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	6	83,492,633 - 83,507,502 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	6	83,493,200 - 83,507,471 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	6	77,129,128 - 77,143,413 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

TRIM63
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	20	106,676,299 - 106,714,394 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	20	106,703,949 - 106,716,656 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666033	9,699,250 - 9,763,031 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Trim63
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624764	10,128,751 - 10,139,687 (-)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624764	10,126,345 - 10,139,829 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Expression

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_005394841	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AGCD01044038	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AGCD01044039	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	GBDI01181650	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSCLAT00000013806 ⟹ ENSCLAP00000013651

Type:

CODING

Position:

Chinchilla Assembly	Chr	Position (strand)	Source
ChiLan1.0 Ensembl	NW_004955452	5,520,269 - 5,531,975 (-)	Ensembl

RefSeq Acc Id:

XM_005394841 ⟹ XP_005394898

Type:

CODING

Position:

Chinchilla Assembly	Chr	Position (strand)	Source
ChiLan1.0	NW_004955452	5,517,969 - 5,531,490 (-)	NCBI

Sequence:

show sequence

AAAAAACCAAAATCTGCGAGGTGAAGGACCTGGGTACTTCTCAAGGTTTGGAGAGATGGGCCGC
CCGGCAGGGCCTCTTCAGGATCTCTGGTAAATGCTGTCCTCGGGTCTGAGGCAGCGGCGTGGGC
TGGGAGGGGCTGCCGTGACTCATCGGAGGAGCTGTCTGATATTCCAGCAAGGGGCGCTGGCTAT
GAACCCCTGCAGCCCCAGGGGCCATCCCCTGCTCGCCAGCTGGCCAGGGGGACACCCATTTCTG
CAGAAAACCCTGGGTACCAGCCCTCCTCTAAGGCCTCCGGACAGCCTGTTCTTGTTTACGACCC
CCGTCCCGGGGGAACGGGATTGCACACCCTCGCATGTGACTGGAGAGGCTGGTCTCTGAGCGCT
GGAGGAAACTCAAGCCCCGCCAGCCACTTGGCATCAGAATGCTCAGCTGGTCCCCTCTTCGGCG
GGGCTCATGTGACCGAGGCTCAGCTATAAATATCAAGGGGGCCTCAGAGCAAGACAGAAATCGG
ACGCCAGGAAGAGACAGCGAAGAGGATCCGAGCTGGTGTTCTGTGGCCCGGGCAGGAGCCTCAG
ATCCGTGTAGAGAGAGGCAGGTAGAGGCGGCAGCTGCACCTCCGGACAGTATGGATTATAAGTC
CAGCCTGATCCAGGATGGGAACCCCATGGAGAACCTGGAGAAGCAGCTGATCTGTCCCATCTGT
CTGGAGATGTTTACCAAGCCCGTGGTCATCTTACCATGCCAGCACAACCTCTGCCGGAAGTGTG
CCAACGACATCTTCCAGGCTGCAAATCCCTACTGGACCAACCGGGTCGGCTCGGTGTCCATGTC
CGGGGGCCGCTTCCGCTGCCCCTCGTGCCGCCACGAGGTGATCATGGACCGTCACGGGGTATAC
GGGCTGCAGAGGAACCTGCTGGTGGAGAACATCATCGACATCTACAAGCAGGAGTGTTCCAGTC
GGCCCCTGCAGAAGGGCAGCCACCCGATGTGCAAGGAGCACGAAGACGAGAAGATCAACATCTA
CTGCCTCACGTGTGAGGTGCCCACGTGCTCCATGTGCAAGGTGTTTGGGGCTCACCAGGCCTGC
GAGGTAGCTCCGCTCCAGAGCGTCTTCCAGGGACAGAAGATGGAGCTGAGTAACTGTATCTCCA
TGCTGGTGGCGGGGAATGACCGCATGCAGACCATCATCACTCAGCTGGAGGACTCCAGTCGAGT
GACCAAGGAGAACAGTCACCAGGTGAAGGAAGAGCTGAGCCAGAAGTTTGACACGCTGTACGCC
ATCCTGGACGAGAAGAAGAGCGAGCTGCTGCAGAGGGTCACACAGGAGCAGGAGGAGAAGCTCA
GCTTCATCGAGGCCCTCATCCAGCAGTACCGGGCGCAGCTGGACAAGTCCACCAAGCTGGTGGA
GACGGCCATCCAGTCCTTGGACGAGCCTGGCGGGGCCACCTTCCTCTTGAGTGCCAAGCAACTC
ATCCAAAGCATCGTGGAGGCGTCCAAGGGCTGCCAGCTGGGGAAGATAGAGCAAGGCTTTGAGA
ACATGGACTACTTCACTTTGGACTTAGAGCACATAGCAGACACCCTGCGGGCCATCGACTTTGG
GATAGAGGAGGACGAGGAGGAGTTCACTGAAGAGGAAGAAGTCCAGGAAGAGATTTCCACAGAA
GAGAAAGAAGAAGGACACCAGTAAGGAGCTGGATGAGTGAGAGACCCTCTGGATGCAGAGAGAC
TGGGGGAAGGGCCCAGGGTGGGAGGGACGGGGCCCCTGGAGGGGTAATGGGGAATTGTGTCTCC
TCTGCTCAGAGAACAGGGACTAGAATAGCAACCCCACCGCTGTGTCCAGCAGTCACTGAACCAG
GATTGGAAATGTGCCTGAAATCGTCACACAGGACACTTTTCTACGTTGGTGCAAAATGAAATAT
TTTGTACGTTTTTAAAATGTGATTTTTGTATATACTTGTCACGTATGCCAATGTGGTGCTTTTT
GTAAAGGGACTTTTGTATAATAACGCTGGGGCACTCTGACTGGCTTTTGAGAAAGGGAGAGAAA
GCCAGGTCAATAGAGCCGCCCGCTTTCTTTCCCCAGTGGGAGGGCTGGGTCACACTCACGGGCC
TAGAAAGAGATAATGTACTGTATTTCAGTGCCCATCCCTGACGTGGGGGAACTGAGTTTGTTAT
ATGTTGTTTTAATAAACGCACAGTGCTCTCTTCCTGTTATTACAAACGA

hide sequence

Protein Sequences


Protein RefSeqs	XP_005394898	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSCLAP00000013651.1

RefSeq Acc Id:

XP_005394898 ⟸ XM_005394841

- Sequence:

show sequence

MLSWSPLRRGSCDRGSAINIKGASEQDRNRTPGRDSEEDPSWCSVARAGASDPCRERQVEAAAA
PPDSMDYKSSLIQDGNPMENLEKQLICPICLEMFTKPVVILPCQHNLCRKCANDIFQAANPYWT
NRVGSVSMSGGRFRCPSCRHEVIMDRHGVYGLQRNLLVENIIDIYKQECSSRPLQKGSHPMCKE
HEDEKINIYCLTCEVPTCSMCKVFGAHQACEVAPLQSVFQGQKMELSNCISMLVAGNDRMQTII
TQLEDSSRVTKENSHQVKEELSQKFDTLYAILDEKKSELLQRVTQEQEEKLSFIEALIQQYRAQ
LDKSTKLVETAIQSLDEPGGATFLLSAKQLIQSIVEASKGCQLGKIEQGFENMDYFTLDLEHIA
DTLRAIDFGIEEDEEEFTEEEEVQEEISTEEKEEGHQ

hide sequence

Ensembl Acc Id:

ENSCLAP00000013651 ⟸ ENSCLAT00000013806

Protein Domains

B box-type COS RING-type

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSCLAG00000009429	Ensembl, UniProtKB/TrEMBL
Ensembl Transcript	ENSCLAT00000013806.1	UniProtKB/TrEMBL
Gene3D-CATH	1.20.5.170	UniProtKB/TrEMBL
	3.30.40.10	UniProtKB/TrEMBL
	Classic Zinc Finger	UniProtKB/TrEMBL
InterPro	Bbox_C	UniProtKB/TrEMBL
	COS_domain	UniProtKB/TrEMBL
	TRIM/RBCC	UniProtKB/TrEMBL
	Znf-RING_LisH	UniProtKB/TrEMBL
	Znf_B-box	UniProtKB/TrEMBL
	Znf_RING	UniProtKB/TrEMBL
	Znf_RING/FYVE/PHD	UniProtKB/TrEMBL
	Znf_RING_CS	UniProtKB/TrEMBL
NCBI Gene	Trim63	ENTREZGENE
PANTHER	E3 UBIQUITIN-PROTEIN LIGASE TRIM	UniProtKB/TrEMBL
	E3 UBIQUITIN-PROTEIN LIGASE TRIM63	UniProtKB/TrEMBL
Pfam	zf-B_box	UniProtKB/TrEMBL
	zf-RING_UBOX	UniProtKB/TrEMBL
PROSITE	COS	UniProtKB/TrEMBL
	ZF_BBOX	UniProtKB/TrEMBL
	ZF_RING_1	UniProtKB/TrEMBL
	ZF_RING_2	UniProtKB/TrEMBL
SMART	BBC	UniProtKB/TrEMBL
	BBOX	UniProtKB/TrEMBL
	RING	UniProtKB/TrEMBL
Superfamily-SCOP	B-box zinc-binding domain	UniProtKB/TrEMBL
	RING/U-box	UniProtKB/TrEMBL
UniProt	A0A8C2VJ90_CHILA	UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2016-08-03	Trim63	tripartite motif containing 63		tripartite motif containing 63, E3 ubiquitin protein ligase	Symbol and/or name change	5135510	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Send us a Message

Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD