| 1311529 | Tox3 | TOX high mobility group box family member 3 | ENCODES a protein that exhibits chromatin binding (ortholog); phosphoprotein binding (ortholog); protein homodimerization activity (ortholog); INVOLVED IN calcium-mediated signaling; positive regulation of DNA-templated transcription; negative regulation of neuron apoptotic process (ortholog); ASSOC IATED WITH Breast Neoplasms (ortholog); Cleft Lip with or without Cleft Palate, Nonsyndromic, 7 (ortholog); Liver Neoplasms (ortholog); FOUND IN cytosol (ortholog); nucleoplasm (ortholog); INTERACTS WITH (+)-schisandrin B; 2,3,7,8-tetrachlorodibenzodioxine; 6-propyl-2-thiouracil | 19 | 32820957 | 32929776 | Rat | 137 | symbol , PhenoGen | gene, protein-coding, VALIDATED [RefSeq] |
| 1323035 | TOX3 | TOX high mobility group box family member 3 | The protein encoded by this gene contains an HMG-box, indicating that it may be involved in bending and unwinding of DNA and alteration of chromatin structure. The C-terminus of the encoded protein is glutamine-rich due to CAG repeats in the coding sequence. A minor allele of this gene has been impl icated in an elevated risk of breast cancer. Two transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Apr 2009] | 16 | 52436416 | 52547802 | Human | 128 | symbol , COSMIC , Human Proteome Map | gene, protein-coding, VALIDATED [RefSeq] |
| 1551816 | Tox3 | TOX high mobility group box family member 3 | Predicted to enable chromatin DNA binding activity; phosphoprotein binding activity; and protein homodimerization activity. Predicted to be involved in calcium-mediated signaling; negative regulation of neuron apoptotic process; and positive regulation of transcription by RNA polymerase II. Predicte d to be located in cytosol and nucleoplasm. Predicted to be active in nucleus. Is expressed in several structures, including central nervous system; embryo mesenchyme; genitourinary system; gut; and sensory organ. Orthologous to human TOX3 (TOX high mobility group box family member 3). [provided by Alliance of Genome Resources, Jul 2025] | 8 | 90973665 | 91075746 | Mouse | 141 | symbol , PhenoGen , description | gene, protein-coding, VALIDATED [RefSeq] |
| 8919179 | Tox3 | TOX high mobility group box family member 3 | ENCODES a protein that exhibits chromatin binding (ortholog); phosphoprotein binding (ortholog); protein homodimerization activity (ortholog); INVOLVED IN calcium-mediated signaling (ortholog); negative regulation of neuron apoptotic process (ortholog); positive regulation of DNA-templated transcrip tion (ortholog); ASSOCIATED WITH Breast Neoplasms (ortholog); Cleft Lip with or without Cleft Palate, Nonsyndromic, 7 (ortholog); Liver Neoplasms (ortholog); FOUND IN cytosol (ortholog); nucleoplasm (ortholog) | NW_004955433 | 10328886 | 10426540 | Chinchilla | 19 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 11840435 | TOX3 | TOX high mobility group box family member 3 | ENCODES a protein that exhibits chromatin binding (inferred); chromatin DNA binding (inferred); DNA binding (inferred); INVOLVED IN calcium-mediated signaling (ortholog); positive regulation of DNA-templated transcription (ortholog); ASSOCIATED WITH Breast Neoplasms (ortholog); Cleft Lip with or wit hout Cleft Palate, Nonsyndromic, 7 (ortholog); Liver Neoplasms (ortholog); FOUND IN cytosol (inferred); nucleoplasm (inferred); nucleus (inferred) | 16 | 32690290 | 32800974 | Bonobo | 26 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12278448 | TOX3 | TOX high mobility group box family member 3 | ENCODES a protein that exhibits chromatin binding (inferred); DNA binding (inferred); phosphoprotein binding (inferred); INVOLVED IN calcium-mediated signaling (ortholog); positive regulation of DNA-templated transcription (ortholog); ASSOCIATED WITH Breast Neoplasms (ortholog); Cleft Lip with or wi thout Cleft Palate, Nonsyndromic, 7 (ortholog); Liver Neoplasms (ortholog); FOUND IN cytosol (inferred); nucleoplasm (inferred); nucleus (inferred) | 2 | 62981706 | 63087519 | Dog | 26 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12579737 | Tox3 | TOX high mobility group box family member 3 | ENCODES a protein that exhibits chromatin binding (inferred); chromatin DNA binding (inferred); DNA binding (inferred); INVOLVED IN calcium-mediated signaling (ortholog); positive regulation of DNA-templated transcription (ortholog); ASSOCIATED WITH Breast Neoplasms (ortholog); Cleft Lip with or wit hout Cleft Palate, Nonsyndromic, 7 (ortholog); Liver Neoplasms (ortholog); FOUND IN cytosol (inferred); nucleoplasm (inferred); nucleus (inferred) | NW_004936475 | 5283615 | 5388104 | Squirrel | 26 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18908580 | Tox3 | TOX high mobility group box family member 3 | ENCODES a protein that exhibits chromatin binding (ortholog); phosphoprotein binding (ortholog); protein homodimerization activity (ortholog); INVOLVED IN calcium-mediated signaling (ortholog); negative regulation of neuron apoptotic process (ortholog); positive regulation of DNA-templated transcrip tion (ortholog); ASSOCIATED WITH Breast Neoplasms (ortholog); Cleft Lip with or without Cleft Palate, Nonsyndromic, 7 (ortholog); Liver Neoplasms (ortholog); FOUND IN cytosol (ortholog); nucleoplasm (ortholog) | | | | Naked Mole-Rat | 26 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 14259469 | TOX3 | TOX high mobility group box family member 3 | ENCODES a protein that exhibits chromatin binding (inferred); DNA binding (inferred); phosphoprotein binding (inferred); INVOLVED IN calcium-mediated signaling (ortholog); positive regulation of DNA-templated transcription (ortholog); ASSOCIATED WITH Breast Neoplasms (ortholog); Cleft Lip with or wi thout Cleft Palate, Nonsyndromic, 7 (ortholog); Liver Neoplasms (ortholog); FOUND IN cytosol (inferred); nucleoplasm (inferred); nucleus (inferred) | | | | Pig | 26 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 155251021 | tox3 | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 18397076 | TOX3 | TOX high mobility group box family member 3 | ENCODES a protein that exhibits chromatin binding (inferred); chromatin DNA binding (inferred); DNA binding (inferred); INVOLVED IN calcium-mediated signaling (ortholog); positive regulation of DNA-templated transcription (ortholog); ASSOCIATED WITH Breast Neoplasms (ortholog); Cleft Lip with or wit hout Cleft Palate, Nonsyndromic, 7 (ortholog); Liver Neoplasms (ortholog); FOUND IN cytosol (inferred); nucleoplasm (inferred); nucleus (inferred) | | | | Green Monkey | 26 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 155251022 | tox3.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 155235039 | tox3.S | | | | | | African Clawed Frog | | symbol | gene, null |
| 1585613 | Tox3l1 | TOX high mobility group box family member 3 like 1 | | 2 | 155710403 | 155742735 | Rat | | symbol , PhenoGen | gene, ncrna, VALIDATED [RefSeq] |