| 628735 | Tnfsf15 | TNF superfamily member 15 | ENCODES a protein that exhibits cytokine activity (inferred); tumor necrosis factor receptor binding (inferred); INVOLVED IN activation of NF-kappaB-inducing kinase activity (ortholog); PARTICIPATES IN cytokine mediated signaling pathway; ASSOCIATED WITH Crohn's disease (ortholog); Enteritis (orthol og); Inflammation (ortholog); FOUND IN plasma membrane (ortholog); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 3,4-methylenedioxymethamphetamine; 6-propyl-2-thiouracil | 5 | 82150376 | 82171743 | Rat | 120 | symbol , PhenoGen | gene, protein-coding, VALIDATED [RefSeq] |
| 737096 | TNFSF15 | TNF superfamily member 15 | The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This protein is abundantly expressed in endothelial cells, but is not expressed in either B or T cells. The expression of this protein is inducible by TNF and IL-1 alpha. This cytokine is a ligand for receptor TNFRSF25 and decoy receptor TNFRSF21/DR6. It can activate NF-kappaB and MAP kinases, and acts as an autocrine factor to induce apoptosis in endothelial cells. This cytokine is also found to inhibit endothelial cell proliferation, and thus may function as an angiogenesis inhibitor. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2011] | 9 | 114784635 | 114806039 | Human | 168 | symbol , COSMIC , Human Proteome Map | gene, protein-coding, REVIEWED [RefSeq] |
| 737097 | Tnfsf15 | tumor necrosis factor (ligand) superfamily, member 15 | Predicted to enable cytokine activity and death receptor binding activity. Predicted to be involved in cell surface receptor signaling pathway; positive regulation of cytokine production; and positive regulation of signal transduction. Predicted to be located in plasma membrane. Predicted to be acti ve in extracellular space. Used to study inflammatory bowel disease 16. Orthologous to human TNFSF15 (TNF superfamily member 15). [provided by Alliance of Genome Resources, Apr 2025] | 4 | 63642837 | 63663296 | Mouse | 132 | symbol , PhenoGen , description | gene, protein-coding, VALIDATED [RefSeq] |
| 8843695 | Tnfsf15 | TNF superfamily member 15 | INVOLVED IN activation of NF-kappaB-inducing kinase activity (ortholog); ASSOCIATED WITH Crohn's disease (ortholog); Enteritis (ortholog); Inflammation (ortholog); FOUND IN plasma membrane (ortholog) | NW_004955419 | 12863617 | 12884498 | Chinchilla | 12 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 11819566 | TNFSF15 | TNF superfamily member 15 | ENCODES a protein that exhibits cytokine activity (inferred); signaling receptor binding (inferred); tumor necrosis factor receptor binding (inferred); INVOLVED IN activation of NF-kappaB-inducing kinase activity (ortholog); ASSOCIATED WITH Crohn's disease (ortholog); Enteritis (ortholog); Inflammat ion (ortholog); FOUND IN extracellular space (inferred); membrane (inferred); plasma membrane (inferred) | 9 | 85881800 | 85904191 | Bonobo | 20 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12325984 | TNFSF15 | TNF superfamily member 15 | ENCODES a protein that exhibits cytokine activity (inferred); tumor necrosis factor receptor binding (inferred); INVOLVED IN activation of NF-kappaB-inducing kinase activity (ortholog); ASSOCIATED WITH Crohn's disease (ortholog); Enteritis (ortholog); Inflammation (ortholog); FOUND IN plasma membran e (ortholog) | 11 | 68887858 | 68909406 | Dog | 19 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12541830 | Tnfsf15 | TNF superfamily member 15 | ENCODES a protein that exhibits cytokine activity (inferred); tumor necrosis factor receptor binding (inferred); INVOLVED IN activation of NF-kappaB-inducing kinase activity (ortholog); ASSOCIATED WITH Crohn's disease (ortholog); Enteritis (ortholog); Inflammation (ortholog); FOUND IN extracellular space (inferred); membrane (inferred); plasma membrane (inferred) | NW_004936487 | 3959224 | 3975959 | Squirrel | 19 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18914540 | Tnfsf15 | TNF superfamily member 15 | ENCODES a protein that exhibits cytokine activity (inferred); tumor necrosis factor receptor binding (inferred); INVOLVED IN activation of NF-kappaB-inducing kinase activity (ortholog); ASSOCIATED WITH Crohn's disease (ortholog); Enteritis (ortholog); Inflammation (ortholog); FOUND IN extracellular space (inferred); membrane (inferred); plasma membrane (inferred) | | | | Naked Mole-Rat | 19 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 14077783 | TNFSF15 | TNF superfamily member 15 | ENCODES a protein that exhibits cytokine activity (inferred); tumor necrosis factor receptor binding (inferred); INVOLVED IN activation of NF-kappaB-inducing kinase activity (ortholog); ASSOCIATED WITH Crohn's disease (ortholog); Enteritis (ortholog); Inflammation (ortholog); FOUND IN extracellular space (inferred); membrane (inferred); plasma membrane (inferred); INTERACTS WITH deoxynivalenol | | | | Pig | 25 | symbol | gene, protein-coding, VALIDATED [RefSeq] |
| 625887524 | Tnfsf15 | TNF superfamily member 15 | INVOLVED IN activation of NF-kappaB-inducing kinase activity (ortholog); ASSOCIATED WITH Crohn's disease (ortholog); Enteritis (ortholog); Inflammation (ortholog); FOUND IN plasma membrane (ortholog) | | | | Black Rat | 12 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18485075 | TNFSF15 | TNF superfamily member 15 | ENCODES a protein that exhibits cytokine activity (inferred); signaling receptor binding (inferred); tumor necrosis factor receptor binding (inferred); INVOLVED IN activation of NF-kappaB-inducing kinase activity (ortholog); ASSOCIATED WITH Crohn's disease (ortholog); Enteritis (ortholog); Inflammat ion (ortholog); FOUND IN extracellular space (inferred); membrane (inferred); plasma membrane (inferred) | | | | Green Monkey | 20 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 155259869 | tnfsf15 | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 155245283 | tnfsf15.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 155252635 | tnfsf15.S | | | | | | African Clawed Frog | | symbol | gene, null |
