ENCODES a protein that exhibits phospholipid scramblase activity (ortholog); INVOLVED IN autophagy; autophagosome assembly (ortholog); autophagosome membrane docking (ortholog); ASSOCIATED WITH Monoclonal B-Cell Lymphocytosis (ortholog); FOUND IN autophagosome membrane; endoplasmic reticulum (orthol
This gene encodes a transmembrane protein that plays a key regulatory role in the process of autophagy. The ectopic overexpression of the encoded protein in cultured cells triggers autophagy even under nutrient-rich conditions. This gene is overexpressed in pancreatitis affected acinar cells where t
he encoded protein mediates sequestration and degradation of potentially deleterious activated zymogen granules in a process termed, zymophagy. [provided by RefSeq, Jul 2016]
Predicted to enable phospholipid scramblase activity. Involved in autophagy and lipoprotein transport. Acts upstream of or within embryo implantation. Located in phagophore assembly site. Orthologous to human VMP1 (vacuole membrane protein 1). [provided by Alliance of Genome Resources, Jul 2025]
ENCODES a protein that exhibits phospholipid scramblase activity (inferred); INVOLVED IN embryo implantation (ortholog); positive regulation of ATPase-coupled calcium transmembrane transporter activity (ortholog); ASSOCIATED WITH Monoclonal B-Cell Lymphocytosis (ortholog); FOUND IN autophagosome mem