VMP1 (vacuole membrane protein 1) - Rat Genome Database

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Gene: VMP1 (vacuole membrane protein 1) Homo sapiens
Analyze
Symbol: VMP1
Name: vacuole membrane protein 1
RGD ID: 731420
HGNC Page HGNC
Description: Involved in several processes, including lipoprotein transport; macroautophagy; and mitochondrion-endoplasmic reticulum membrane tethering. Located in endoplasmic reticulum membrane and nucleolus.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: DKFZp566I133; ectopic P-granules autophagy protein 3 homolog; EPG3; TANGO5; TMEM49; transmembrane protein 49; transport and golgi organization 5 homolog
RGD Orthologs
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1759,707,192 - 59,842,255 (+)EnsemblGRCh38hg38GRCh38
GRCh381759,707,654 - 59,842,255 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh371757,785,015 - 57,919,616 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361755,139,811 - 55,273,235 (+)NCBINCBI36hg18NCBI36
Build 341755,139,810 - 55,273,235NCBI
Celera1754,248,613 - 54,381,467 (+)NCBI
Cytogenetic Map17q23.1NCBI
HuRef1753,157,402 - 53,290,443 (+)NCBIHuRef
CHM1_11757,849,881 - 57,981,975 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
17beta-estradiol  (EXP)
17beta-hydroxy-5alpha-androstan-3-one  (EXP)
2,2',5,5'-tetrachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2-butoxyethanol  (ISO)
2-hydroxypropanoic acid  (EXP)
3H-1,2-dithiole-3-thione  (ISO)
6-propyl-2-thiouracil  (ISO)
actinomycin D  (EXP)
aflatoxin B1  (EXP)
ammonium chloride  (ISO)
amphetamine  (ISO)
antirheumatic drug  (EXP)
aristolochic acid  (EXP)
benzo[a]pyrene  (EXP)
benzo[a]pyrene diol epoxide I  (EXP)
benzo[b]fluoranthene  (EXP)
bisphenol A  (EXP,ISO)
cadmium atom  (EXP,ISO)
carbon nanotube  (ISO)
choline  (ISO)
copper(II) sulfate  (EXP)
cyclosporin A  (EXP)
DDT  (EXP)
dehydroepiandrosterone  (EXP)
dibenz[a,h]anthracene  (EXP)
dibutyl phthalate  (ISO)
dicrotophos  (EXP)
dieldrin  (EXP)
dorsomorphin  (EXP)
doxorubicin  (EXP)
ethanol  (ISO)
fenbuconazole  (EXP)
fenhexamid  (EXP)
fludioxonil  (EXP)
fluoranthene  (EXP)
folic acid  (ISO)
formaldehyde  (EXP)
geldanamycin  (EXP)
gemcitabine  (EXP)
hypochlorous acid  (ISO)
indometacin  (EXP)
isotretinoin  (EXP)
ivermectin  (EXP)
L-methionine  (ISO)
leflunomide  (EXP,ISO)
levofloxacin  (ISO)
methyl beta-cyclodextrin  (EXP)
methylmercury chloride  (EXP)
methylparaben  (EXP)
N-methyl-4-phenylpyridinium  (ISO)
nickel atom  (EXP)
nickel dichloride  (EXP)
oxaliplatin  (ISO)
paracetamol  (EXP)
paraquat  (ISO)
PCB138  (ISO)
phenobarbital  (ISO)
pirinixic acid  (EXP)
pregnenolone 16alpha-carbonitrile  (ISO)
propiconazole  (ISO)
rac-lactic acid  (EXP)
SB 431542  (EXP)
sodium dichromate  (ISO)
sodium dodecyl sulfate  (EXP)
sulindac sulfide  (EXP)
tetrachloromethane  (ISO)
titanium dioxide  (ISO)
topotecan  (ISO)
trichostatin A  (EXP)
trimellitic anhydride  (ISO)
valproic acid  (EXP)

References

Additional References at PubMed
PMID:11076863   PMID:11230166   PMID:11256614   PMID:11785947   PMID:12477932   PMID:15466293   PMID:15489336   PMID:16381901   PMID:17724469   PMID:17940279   PMID:18384814   PMID:18550798  
PMID:19019082   PMID:19056683   PMID:19322201   PMID:19490893   PMID:20299819   PMID:21173155   PMID:21467264   PMID:21873635   PMID:22144109   PMID:22333543   PMID:22404213   PMID:22535956  
PMID:22810586   PMID:22971212   PMID:23118302   PMID:23316280   PMID:23460482   PMID:23710913   PMID:24365149   PMID:24623722   PMID:26186194   PMID:26328607   PMID:26638075   PMID:27023910  
PMID:27415425   PMID:27861594   PMID:28380382   PMID:28514442   PMID:28692057   PMID:28890335   PMID:29180619   PMID:29507755   PMID:29509190   PMID:30093494   PMID:30833792   PMID:30933966  
PMID:31056421   PMID:31442252   PMID:31526472   PMID:31527615   PMID:32149426   PMID:32296183   PMID:33226137   PMID:33318473   PMID:33845483   PMID:34079125  


Genomics

Comparative Map Data
VMP1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1759,707,192 - 59,842,255 (+)EnsemblGRCh38hg38GRCh38
GRCh381759,707,654 - 59,842,255 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh371757,785,015 - 57,919,616 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361755,139,811 - 55,273,235 (+)NCBINCBI36hg18NCBI36
Build 341755,139,810 - 55,273,235NCBI
Celera1754,248,613 - 54,381,467 (+)NCBI
Cytogenetic Map17q23.1NCBI
HuRef1753,157,402 - 53,290,443 (+)NCBIHuRef
CHM1_11757,849,881 - 57,981,975 (+)NCBICHM1_1
Vmp1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391186,474,684 - 86,574,662 (-)NCBIGRCm39mm39
GRCm39 Ensembl1186,474,691 - 86,574,662 (-)Ensembl
GRCm381186,583,858 - 86,683,836 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1186,583,865 - 86,683,836 (-)EnsemblGRCm38mm10GRCm38
MGSCv371186,397,367 - 86,497,324 (-)NCBIGRCm37mm9NCBIm37
MGSCv361186,400,060 - 86,500,017 (-)NCBImm8
Celera1196,199,772 - 96,299,263 (-)NCBICelera
Cytogenetic Map11CNCBI
Vmp1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21071,405,058 - 71,505,045 (-)NCBImRatBN7.2
mRatBN7.2 Ensembl1071,405,452 - 71,505,007 (-)Ensembl
Rnor_6.01073,901,988 - 74,001,900 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1073,902,837 - 74,001,895 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01076,098,589 - 76,197,394 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41074,865,123 - 74,964,158 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11074,879,495 - 74,978,528 (-)NCBI
Celera1070,326,998 - 70,425,606 (-)NCBICelera
Cytogenetic Map10q26NCBI
Vmp1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554513,265,109 - 3,370,610 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554513,265,109 - 3,370,610 (-)NCBIChiLan1.0ChiLan1.0
VMP1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Mhudiblu_PPA_v01753,773,215 - 53,907,992 (+)NCBIMhudiblu_PPA_v0panPan3
VMP1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1934,197,045 - 34,340,401 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl934,197,133 - 34,339,597 (+)EnsemblCanFam3.1canFam3CanFam3.1
ROS_Cfam_1.0935,007,411 - 35,151,837 (+)NCBI
Vmp1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440560233,427,171 - 33,543,081 (+)NCBI
SpeTri2.0NW_0049364903,532,985 - 3,648,009 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
VMP1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11633,606,863 - 33,738,427 (-)NCBI
ChlSab1.1 Ensembl1633,609,202 - 33,738,289 (-)Ensembl
Vero_WHO_p1.0NW_0236660774,392,201 - 4,528,582 (-)NCBI
Vmp1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046248711,519,662 - 1,626,040 (+)NCBI

Position Markers
SHGC-64257  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371757,917,735 - 57,917,824UniSTSGRCh37
Build 361755,272,517 - 55,272,606RGDNCBI36
Celera1754,381,248 - 54,381,337RGD
Cytogenetic Map17q23.1UniSTS
HuRef1753,290,224 - 53,290,313UniSTS
TNG Radiation Hybrid Map1726111.0UniSTS
RH91780  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371757,917,788 - 57,917,888UniSTSGRCh37
Build 361755,272,570 - 55,272,670RGDNCBI36
Celera1754,381,301 - 54,381,401RGD
Cytogenetic Map17q23.1UniSTS
HuRef1753,290,277 - 53,290,377UniSTS
GeneMap99-GB4 RH Map17372.1UniSTS
G42203  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371757,849,483 - 57,849,602UniSTSGRCh37
Build 361755,204,265 - 55,204,384RGDNCBI36
Celera1754,313,449 - 54,313,568RGD
Cytogenetic Map17q23.1UniSTS
HuRef1753,222,095 - 53,222,214UniSTS
G42241  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371757,869,674 - 57,869,807UniSTSGRCh37
Build 361755,224,456 - 55,224,589RGDNCBI36
Celera1754,333,641 - 54,333,774RGD
Cytogenetic Map17q23.1UniSTS
HuRef1753,242,287 - 53,242,420UniSTS
G42376  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371757,908,795 - 57,908,884UniSTSGRCh37
Build 361755,263,577 - 55,263,666RGDNCBI36
Celera1754,372,309 - 54,372,398RGD
Cytogenetic Map17q23.1UniSTS
HuRef1753,281,281 - 53,281,370UniSTS
G42384  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371757,863,910 - 57,864,097UniSTSGRCh37
Build 361755,218,692 - 55,218,879RGDNCBI36
Celera1754,327,877 - 54,328,064RGD
Cytogenetic Map17q23.1UniSTS
HuRef1753,236,523 - 53,236,710UniSTS
RH46129  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371757,918,157 - 57,918,341UniSTSGRCh37
Build 361755,272,939 - 55,273,123RGDNCBI36
Celera1754,381,670 - 54,381,854RGD
Cytogenetic Map17q23.1UniSTS
HuRef1753,290,646 - 53,290,830UniSTS
GeneMap99-GB4 RH Map17377.81UniSTS
NCBI RH Map17665.5UniSTS
RH48465  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371757,915,537 - 57,915,682UniSTSGRCh37
Build 361755,270,319 - 55,270,464RGDNCBI36
Celera1754,379,050 - 54,379,195RGD
Cytogenetic Map17q23.1UniSTS
HuRef1753,288,026 - 53,288,171UniSTS
GeneMap99-GB4 RH Map17372.1UniSTS

miRNA Target Status

Confirmed Target Of
miRNA GeneMature miRNAMethod NameResult TypeData TypeSupport TypePMID
MIR210hsa-miR-210-3pMirtarbaseexternal_infoLuciferase reporter assay//Microarray//Western bloFunctional MTI22144109
MIR210hsa-miR-210-3pOncomiRDBexternal_infoNANA22144109
MIR210hsa-miR-210-5pMirecordsexternal_info{changed}NA22144109

Predicted Target Of
Summary Value
Count of predictions:2886
Count of miRNA genes:1061
Interacting mature miRNAs:1292
Transcripts:ENST00000262291, ENST00000536180, ENST00000537567, ENST00000539763, ENST00000545362, ENST00000585847, ENST00000586245, ENST00000587259, ENST00000587470, ENST00000587945, ENST00000588131, ENST00000588617, ENST00000588915, ENST00000589823, ENST00000591315, ENST00000591782, ENST00000591877, ENST00000592106, ENST00000592619, ENST00000592790, ENST00000593168
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system sensory system visual system adipose tissue appendage entire extraembryonic component pharyngeal arch
High 11
Medium 2429 2713 1702 602 1941 444 4021 1616 3044 399 1435 1606 171 1203 2456 4
Low 8 277 24 22 10 21 335 579 688 19 14 6 3 1 1 332 1 2
Below cutoff 1 1 1 2 1 1 1

Sequence

Nucleotide Sequences
RefSeq Transcripts NG_051107 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001329394 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001329395 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001329396 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001329397 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001329398 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001329399 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001329400 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001329401 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001329402 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_030938 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AB047551 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC004686 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC025858 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC040904 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC091271 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC244499 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF161410 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF214006 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK024969 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK025987 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK293578 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK293664 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK294854 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK301254 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL136711 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AX083452 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AX775965 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC009758 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC024020 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BM803108 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BQ002999 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CA412810 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CB216599 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH471109 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CR533521 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DC339443 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DC428792 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENST00000262291   ⟹   ENSP00000262291
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1759,707,654 - 59,842,255 (+)Ensembl
RefSeq Acc Id: ENST00000585847   ⟹   ENSP00000465947
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1759,707,651 - 59,765,068 (+)Ensembl
RefSeq Acc Id: ENST00000586245   ⟹   ENSP00000466579
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1759,707,650 - 59,765,111 (+)Ensembl
RefSeq Acc Id: ENST00000587259   ⟹   ENSP00000465397
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1759,729,715 - 59,737,517 (+)Ensembl
RefSeq Acc Id: ENST00000587470
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1759,837,951 - 59,840,315 (+)Ensembl
RefSeq Acc Id: ENST00000587945   ⟹   ENSP00000466413
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1759,707,664 - 59,773,881 (+)Ensembl
RefSeq Acc Id: ENST00000588131
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1759,707,671 - 59,735,744 (+)Ensembl
RefSeq Acc Id: ENST00000588617
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1759,837,855 - 59,840,207 (+)Ensembl
RefSeq Acc Id: ENST00000588915
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1759,707,192 - 59,707,676 (+)Ensembl
RefSeq Acc Id: ENST00000589823   ⟹   ENSP00000466198
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1759,707,696 - 59,765,138 (+)Ensembl
RefSeq Acc Id: ENST00000591315   ⟹   ENSP00000466511
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1759,707,718 - 59,738,947 (+)Ensembl
RefSeq Acc Id: ENST00000591782
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1759,837,628 - 59,840,223 (+)Ensembl
RefSeq Acc Id: ENST00000591877   ⟹   ENSP00000467350
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1759,773,754 - 59,840,024 (+)Ensembl
RefSeq Acc Id: ENST00000592106   ⟹   ENSP00000467093
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1759,707,706 - 59,737,474 (+)Ensembl
RefSeq Acc Id: ENST00000592619   ⟹   ENSP00000465911
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1759,735,338 - 59,840,106 (+)Ensembl
RefSeq Acc Id: ENST00000592790
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1759,837,931 - 59,842,255 (+)Ensembl
RefSeq Acc Id: ENST00000593168   ⟹   ENSP00000465972
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1759,707,648 - 59,773,804 (+)Ensembl
RefSeq Acc Id: NM_001329394   ⟹   NP_001316323
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381759,707,654 - 59,842,255 (+)NCBI
Sequence:
RefSeq Acc Id: NM_001329395   ⟹   NP_001316324
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381759,707,654 - 59,842,255 (+)NCBI
Sequence:
RefSeq Acc Id: NM_001329396   ⟹   NP_001316325
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381759,707,654 - 59,842,255 (+)NCBI
Sequence:
RefSeq Acc Id: NM_001329397   ⟹   NP_001316326
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381759,707,654 - 59,842,255 (+)NCBI
Sequence:
RefSeq Acc Id: NM_001329398   ⟹   NP_001316327
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381759,707,654 - 59,842,255 (+)NCBI
Sequence:
RefSeq Acc Id: NM_001329399   ⟹   NP_001316328
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381759,707,654 - 59,842,255 (+)NCBI
Sequence:
RefSeq Acc Id: NM_001329400   ⟹   NP_001316329
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381759,707,654 - 59,842,255 (+)NCBI
Sequence:
RefSeq Acc Id: NM_001329401   ⟹   NP_001316330
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381759,707,654 - 59,842,255 (+)NCBI
Sequence:
RefSeq Acc Id: NM_001329402   ⟹   NP_001316331
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381759,707,654 - 59,842,255 (+)NCBI
Sequence:
RefSeq Acc Id: NM_030938   ⟹   NP_112200
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381759,707,654 - 59,842,255 (+)NCBI
GRCh371757,784,553 - 57,919,610 (+)NCBI
Build 361755,139,811 - 55,273,235 (+)NCBI Archive
Celera1754,248,613 - 54,381,467 (+)RGD
HuRef1753,157,402 - 53,290,443 (+)RGD
CHM1_11757,849,881 - 57,981,975 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_001316323 (Get FASTA)   NCBI Sequence Viewer  
  NP_001316324 (Get FASTA)   NCBI Sequence Viewer  
  NP_001316325 (Get FASTA)   NCBI Sequence Viewer  
  NP_001316326 (Get FASTA)   NCBI Sequence Viewer  
  NP_001316327 (Get FASTA)   NCBI Sequence Viewer  
  NP_001316328 (Get FASTA)   NCBI Sequence Viewer  
  NP_001316329 (Get FASTA)   NCBI Sequence Viewer  
  NP_001316330 (Get FASTA)   NCBI Sequence Viewer  
  NP_001316331 (Get FASTA)   NCBI Sequence Viewer  
  NP_112200 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAF28970 (Get FASTA)   NCBI Sequence Viewer  
  AAH09758 (Get FASTA)   NCBI Sequence Viewer  
  AAL36461 (Get FASTA)   NCBI Sequence Viewer  
  BAF47368 (Get FASTA)   NCBI Sequence Viewer  
  BAG57048 (Get FASTA)   NCBI Sequence Viewer  
  BAG57110 (Get FASTA)   NCBI Sequence Viewer  
  BAG57958 (Get FASTA)   NCBI Sequence Viewer  
  BAG62821 (Get FASTA)   NCBI Sequence Viewer  
  CAB66646 (Get FASTA)   NCBI Sequence Viewer  
  CAC33315 (Get FASTA)   NCBI Sequence Viewer  
  CAE11682 (Get FASTA)   NCBI Sequence Viewer  
  CAG38552 (Get FASTA)   NCBI Sequence Viewer  
  EAW94390 (Get FASTA)   NCBI Sequence Viewer  
  EAW94391 (Get FASTA)   NCBI Sequence Viewer  
  EAW94392 (Get FASTA)   NCBI Sequence Viewer  
  EAW94393 (Get FASTA)   NCBI Sequence Viewer  
  Q96GC9 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: NP_112200   ⟸   NM_030938
- Peptide Label: isoform 1
- UniProtKB: Q96GC9 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_001316323   ⟸   NM_001329394
- Peptide Label: isoform 1
- UniProtKB: Q96GC9 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_001316324   ⟸   NM_001329395
- Peptide Label: isoform 2
- UniProtKB: D3DU01 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001316326   ⟸   NM_001329397
- Peptide Label: isoform 4
- UniProtKB: Q96GC9 (UniProtKB/Swiss-Prot),   B4DEJ9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001316325   ⟸   NM_001329396
- Peptide Label: isoform 3
- Sequence:
RefSeq Acc Id: NP_001316327   ⟸   NM_001329398
- Peptide Label: isoform 5
- Sequence:
RefSeq Acc Id: NP_001316328   ⟸   NM_001329399
- Peptide Label: isoform 6
- UniProtKB: B4DGZ7 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001316330   ⟸   NM_001329401
- Peptide Label: isoform 8
- Sequence:
RefSeq Acc Id: NP_001316329   ⟸   NM_001329400
- Peptide Label: isoform 7
- UniProtKB: B4DED7 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001316331   ⟸   NM_001329402
- Peptide Label: isoform 9
- UniProtKB: Q96GC9 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSP00000465947   ⟸   ENST00000585847
RefSeq Acc Id: ENSP00000466579   ⟸   ENST00000586245
RefSeq Acc Id: ENSP00000465397   ⟸   ENST00000587259
RefSeq Acc Id: ENSP00000466413   ⟸   ENST00000587945
RefSeq Acc Id: ENSP00000466198   ⟸   ENST00000589823
RefSeq Acc Id: ENSP00000262291   ⟸   ENST00000262291
RefSeq Acc Id: ENSP00000466511   ⟸   ENST00000591315
RefSeq Acc Id: ENSP00000467350   ⟸   ENST00000591877
RefSeq Acc Id: ENSP00000465911   ⟸   ENST00000592619
RefSeq Acc Id: ENSP00000467093   ⟸   ENST00000592106
RefSeq Acc Id: ENSP00000465972   ⟸   ENST00000593168

Promoters
RGD ID:7235859
Promoter ID:EPDNEW_H23676
Type:initiation region
Name:VMP1_2
Description:vacuole membrane protein 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H23677  
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh381759,707,509 - 59,707,569EPDNEW
RGD ID:7235863
Promoter ID:EPDNEW_H23677
Type:initiation region
Name:VMP1_1
Description:vacuole membrane protein 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H23676  
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh381759,707,665 - 59,707,725EPDNEW

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 17q21.33-24.2(chr17:36449220-68170214)x3 copy number gain See cases [RCV000050957] Chr17:36449220..68170214 [GRCh38]
Chr17:48563237..65936105 [GRCh37]
Chr17:45918236..63677950 [NCBI36]
Chr17:17q21.33-24.2
pathogenic
GRCh38/hg38 17q23.2-25.3(chr17:36449220-83086677)x3 copy number gain Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000052483]|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000052483]|See cases [RCV000052483] Chr17:36449220..83086677 [GRCh38]
Chr17:58617905..81044553 [GRCh37]
Chr17:55972687..78637842 [NCBI36]
Chr17:17q23.2-25.3
pathogenic
GRCh38/hg38 17q22-23.1(chr17:59481220-59756756)x1 copy number loss See cases [RCV000135625] Chr17:59481220..59756756 [GRCh38]
Chr17:57558581..57834117 [GRCh37]
Chr17:54913363..55188899 [NCBI36]
Chr17:17q22-23.1
likely pathogenic|uncertain significance
GRCh38/hg38 17q23.1-25.1(chr17:36449220-75053130)x3 copy number gain See cases [RCV000137437] Chr17:36449220..75053130 [GRCh38]
Chr17:57595736..73049225 [GRCh37]
Chr17:54950518..70560820 [NCBI36]
Chr17:17q23.1-25.1
pathogenic
GRCh38/hg38 17q22-23.1(chr17:57418806-59735464)x1 copy number loss See cases [RCV000140211] Chr17:57418806..59735464 [GRCh38]
Chr17:55496167..57812825 [GRCh37]
Chr17:52851166..55167607 [NCBI36]
Chr17:17q22-23.1
pathogenic
NM_030938.5(VMP1):c.331_332del (p.Leu111fs) deletion Monoclonal B-Cell Lymphocytosis [RCV000208550] Chr17:59738863..59738864 [GRCh38]
Chr17:57816224..57816225 [GRCh37]
Chr17:17q23.1
uncertain significance
GRCh37/hg19 17q22-23.3(chr17:56321134-62080001)x3 copy number gain See cases [RCV000240364] Chr17:56321134..62080001 [GRCh37]
Chr17:17q22-23.3
pathogenic
GRCh37/hg19 17q21.33-23.2(chr17:49076980-58740945)x3 copy number gain See cases [RCV000448805] Chr17:49076980..58740945 [GRCh37]
Chr17:17q21.33-23.2
pathogenic
GRCh37/hg19 17q21.31-25.3(chr17:42580684-81085615)x3 copy number gain See cases [RCV000447823] Chr17:42580684..81085615 [GRCh37]
Chr17:17q21.31-25.3
pathogenic
GRCh37/hg19 17p13.3-q25.3(chr17:526-81041938) copy number gain See cases [RCV000511439] Chr17:526..81041938 [GRCh37]
Chr17:17p13.3-q25.3
pathogenic
GRCh37/hg19 17q22-23.2(chr17:56623275-60285107)x1 copy number loss See cases [RCV000511292] Chr17:56623275..60285107 [GRCh37]
Chr17:17q22-23.2
pathogenic
GRCh37/hg19 17p13.3-q25.3(chr17:526-81041938)x3 copy number gain See cases [RCV000512441] Chr17:526..81041938 [GRCh37]
Chr17:17p13.3-q25.3
pathogenic
GRCh37/hg19 17p13.3-q25.3(chr17:7214-81058310)x3 copy number gain not provided [RCV000739320] Chr17:7214..81058310 [GRCh37]
Chr17:17p13.3-q25.3
pathogenic
GRCh37/hg19 17p13.3-q25.3(chr17:12344-81057996)x3 copy number gain not provided [RCV000739325] Chr17:12344..81057996 [GRCh37]
Chr17:17p13.3-q25.3
pathogenic
GRCh37/hg19 17p13.3-q25.3(chr17:8547-81060040)x3 copy number gain not provided [RCV000739324] Chr17:8547..81060040 [GRCh37]
Chr17:17p13.3-q25.3
pathogenic
GRCh37/hg19 17q23.1(chr17:57817697-57955754)x3 copy number gain not provided [RCV000739625] Chr17:57817697..57955754 [GRCh37]
Chr17:17q23.1
benign
GRCh37/hg19 17q22-23.1(chr17:57582867-58080569)x3 copy number gain not provided [RCV000752157] Chr17:57582867..58080569 [GRCh37]
Chr17:17q22-23.1
benign
GRCh37/hg19 17q23.1(chr17:57616400-57986918)x1 copy number loss not provided [RCV001006908] Chr17:57616400..57986918 [GRCh37]
Chr17:17q23.1
likely pathogenic
GRCh37/hg19 17q22-24.2(chr17:57357088-66306668) copy number gain not provided [RCV000767764] Chr17:57357088..66306668 [GRCh37]
Chr17:17q22-24.2
pathogenic
GRCh37/hg19 17q23.1-24.2(chr17:57869604-67078443)x3 copy number gain not provided [RCV000845965] Chr17:57869604..67078443 [GRCh37]
Chr17:17q23.1-24.2
pathogenic

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:29559 AgrOrtholog
COSMIC VMP1 COSMIC
Ensembl Genes ENSG00000062716 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSP00000262291 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSP00000465397 UniProtKB/TrEMBL
  ENSP00000465911 UniProtKB/TrEMBL
  ENSP00000465947 UniProtKB/TrEMBL
  ENSP00000465972 UniProtKB/TrEMBL
  ENSP00000466198 UniProtKB/TrEMBL
  ENSP00000466413 UniProtKB/TrEMBL
  ENSP00000466511 UniProtKB/TrEMBL
  ENSP00000466579 UniProtKB/TrEMBL
  ENSP00000467093 UniProtKB/TrEMBL
  ENSP00000467350 ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENST00000262291 ENTREZGENE, UniProtKB/Swiss-Prot
  ENST00000585847 UniProtKB/TrEMBL
  ENST00000586245 UniProtKB/TrEMBL
  ENST00000587259 UniProtKB/TrEMBL
  ENST00000587945 UniProtKB/TrEMBL
  ENST00000589823 UniProtKB/TrEMBL
  ENST00000591315 UniProtKB/TrEMBL
  ENST00000591877 ENTREZGENE, UniProtKB/TrEMBL
  ENST00000592106 UniProtKB/TrEMBL
  ENST00000592619 UniProtKB/TrEMBL
  ENST00000593168 UniProtKB/TrEMBL
GTEx ENSG00000062716 GTEx
HGNC ID HGNC:29559 ENTREZGENE
Human Proteome Map VMP1 Human Proteome Map
InterPro SNARE_assoc UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report hsa:81671 UniProtKB/Swiss-Prot
NCBI Gene 81671 ENTREZGENE
OMIM 611753 OMIM
Pfam SNARE_assoc UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB PA142670765 PharmGKB
UniProt B4DED7 ENTREZGENE, UniProtKB/TrEMBL
  B4DEJ9 ENTREZGENE, UniProtKB/TrEMBL
  B4DGZ7 ENTREZGENE, UniProtKB/TrEMBL
  D3DU01 ENTREZGENE, UniProtKB/TrEMBL
  K7EK01_HUMAN UniProtKB/TrEMBL
  K7EL46_HUMAN UniProtKB/TrEMBL
  K7EL74_HUMAN UniProtKB/TrEMBL
  K7EL93_HUMAN UniProtKB/TrEMBL
  K7ELS2_HUMAN UniProtKB/TrEMBL
  K7EM96_HUMAN UniProtKB/TrEMBL
  K7EMI0_HUMAN UniProtKB/TrEMBL
  K7EMN6_HUMAN UniProtKB/TrEMBL
  K7ENU2_HUMAN UniProtKB/TrEMBL
  K7EPE7_HUMAN UniProtKB/TrEMBL
  Q96GC9 ENTREZGENE, UniProtKB/Swiss-Prot
UniProt Secondary B4DVV9 UniProtKB/Swiss-Prot
  Q9H0P4 UniProtKB/Swiss-Prot
  Q9P089 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2011-07-27 VMP1  vacuole membrane protein 1  TMEM49  transmembrane protein 49  Symbol and/or name change 5135510 APPROVED