| 1309237 | Tle1 | TLE family member 1, transcriptional corepressor | ENCODES a protein that exhibits chromatin binding (ortholog); DNA-binding transcription factor binding (ortholog); identical protein binding (ortholog); INVOLVED IN negative regulation of anoikis (ortholog); negative regulation of canonical NF-kappaB signal transduction (ortholog); negative regulati on of DNA-templated transcription (ortholog); FOUND IN beta-catenin-TCF complex (ortholog); cytosol (ortholog); nucleoplasm (ortholog); INTERACTS WITH 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine; 2,4-dinitrotoluene | 5 | 90898182 | 90982118 | Rat | 143 | symbol , PhenoGen | gene, protein-coding, VALIDATED [RefSeq] |
| 1319465 | TLE1 | TLE family member 1, transcriptional corepressor | Enables DNA-binding transcription factor binding activity; identical protein binding activity; and transcription corepressor activity. Involved in negative regulation of anoikis; negative regulation of signal transduction; and regulation of gene expression. Located in cytosol and nucleoplasm. Part o f beta-catenin-TCF complex. [provided by Alliance of Genome Resources, Jul 2025] | 9 | 81583683 | 81689547 | Human | 159 | symbol , COSMIC , Human Proteome Map | gene, protein-coding, VALIDATED [RefSeq] |
| 1319466 | Tle1 | transducin-like enhancer of split 1 | Enables chromatin binding activity and transcription corepressor activity. Acts upstream of or within negative regulation of transcription by RNA polymerase II. Located in nucleus. Part of transcription regulator complex. Is expressed in several structures, including alimentary system; central nervo us system; genitourinary system; respiratory system; and sensory organ. Orthologous to human TLE1 (TLE family member 1, transcriptional corepressor). [provided by Alliance of Genome Resources, Jul 2025] | 4 | 72028182 | 72124575 | Mouse | 150 | symbol , PhenoGen , description | gene, protein-coding, VALIDATED [RefSeq] |
| 8903401 | Tle1 | TLE family member 1, transcriptional corepressor | ENCODES a protein that exhibits chromatin binding (ortholog); DNA-binding transcription factor binding (ortholog); identical protein binding (ortholog); INVOLVED IN negative regulation of anoikis (ortholog); negative regulation of canonical NF-kappaB signal transduction (ortholog); negative regulati on of DNA-templated transcription (ortholog); FOUND IN beta-catenin-TCF complex (ortholog); cytosol (ortholog); nucleoplasm (ortholog) | NW_004955530 | 1936936 | 2028803 | Chinchilla | 40 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 11982592 | TLE1 | TLE family member 1, transcriptional corepressor | ENCODES a protein that exhibits chromatin binding (ortholog); INVOLVED IN negative regulation of transcription by RNA polymerase II (ortholog); regulation of DNA-templated transcription (ortholog); regulation of transcription by RNA polymerase II (ortholog); FOUND IN beta-catenin-TCF complex (inferr ed); cytosol (inferred); nucleoplasm (inferred) | 9 | 43150356 | 43258551 | Bonobo | 45 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12233652 | TLE1 | TLE family member 1, transcriptional corepressor | ENCODES a protein that exhibits chromatin binding (ortholog); INVOLVED IN negative regulation of transcription by RNA polymerase II (ortholog); regulation of DNA-templated transcription (ortholog); regulation of transcription by RNA polymerase II (ortholog); FOUND IN beta-catenin-TCF complex (inferr ed); cytosol (inferred); nucleoplasm (inferred) | 1 | 77554718 | 77639608 | Dog | 44 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12700253 | Tle1 | TLE family member 1, transcriptional corepressor | ENCODES a protein that exhibits chromatin binding (ortholog); INVOLVED IN negative regulation of transcription by RNA polymerase II (ortholog); regulation of DNA-templated transcription (ortholog); regulation of transcription by RNA polymerase II (ortholog); FOUND IN beta-catenin-TCF complex (inferr ed); cytosol (inferred); nucleoplasm (inferred) | NW_004936632 | 1316812 | 1407817 | Squirrel | 45 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 155236017 | tle1 | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 14079557 | TLE1 | TLE family member 1, transcriptional corepressor | ENCODES a protein that exhibits chromatin binding (ortholog); INVOLVED IN negative regulation of transcription by RNA polymerase II (ortholog); regulation of DNA-templated transcription (ortholog); regulation of transcription by RNA polymerase II (ortholog); FOUND IN beta-catenin-TCF complex (inferr ed); cytosol (inferred); nucleoplasm (inferred); INTERACTS WITH deoxynivalenol; graphene oxide | | | | Pig | 46 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18503285 | TLE1 | TLE family member 1, transcriptional corepressor | ENCODES a protein that exhibits chromatin binding (ortholog); INVOLVED IN negative regulation of transcription by RNA polymerase II (ortholog); regulation of DNA-templated transcription (ortholog); regulation of transcription by RNA polymerase II (ortholog); FOUND IN beta-catenin-TCF complex (inferr ed); cytosol (inferred); nucleoplasm (inferred) | | | | Green Monkey | 44 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 626015327 | Tle1 | TLE family member 1, transcriptional corepressor | ENCODES a protein that exhibits chromatin binding (ortholog); DNA-binding transcription factor binding (ortholog); identical protein binding (ortholog); INVOLVED IN negative regulation of anoikis (ortholog); negative regulation of canonical NF-kappaB signal transduction (ortholog); negative regulati on of DNA-templated transcription (ortholog); FOUND IN beta-catenin-TCF complex (ortholog); cytosol (ortholog); nucleoplasm (ortholog) | | | | Black Rat | 40 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18910049 | Tle1 | TLE family member 1, transcriptional corepressor | ENCODES a protein that exhibits chromatin binding (ortholog); DNA-binding transcription factor binding (ortholog); identical protein binding (ortholog); INVOLVED IN negative regulation of anoikis (ortholog); negative regulation of canonical NF-kappaB signal transduction (ortholog); negative regulati on of transcription by RNA polymerase II (ortholog); FOUND IN beta-catenin-TCF complex (ortholog); cytosol (ortholog); nucleoplasm (ortholog) | | | | Naked Mole-Rat | 42 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 155236016 | tle1.S | | | | | | African Clawed Frog | | symbol | gene, null |
| 16555773 | TLE1-DT | TLE1 divergent transcript | | 9 | 81689713 | 81776900 | Human | | symbol , COSMIC , name , Human Proteome Map | gene, ncrna, VALIDATED [RefSeq] |
| 4891172 | TLE1P1 | TLE family member 1 pseudogene 1 | INTERACTS WITH lipopolysaccharide; S-(1,2-dichlorovinyl)-L-cysteine; temozolomide | X | 65407877 | 65408674 | Human | 4 | symbol , COSMIC , Human Proteome Map | gene, pseudo, INFERRED [RefSeq] |