| 1563191 | Tigit | T cell immunoreceptor with Ig and ITIM domains | ENCODES a protein that exhibits identical protein binding (ortholog); signaling receptor activity (ortholog); signaling receptor binding (ortholog); INVOLVED IN negative regulation of interleukin-12 production (ortholog); negative regulation of natural killer cell mediated cytotoxicity (ortholog); n egative regulation of T cell activation (ortholog); FOUND IN cell surface (ortholog); plasma membrane (ortholog); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; glyphosate; vinclozolin | 11 | 70534907 | 70552452 | Rat | 61 | symbol , PhenoGen | gene, protein-coding, VALIDATED [RefSeq] |
| 1606681 | TIGIT | T cell immunoreceptor with Ig and ITIM domains | This gene encodes a member of the PVR (poliovirus receptor) family of immunoglobin proteins. The product of this gene is expressed on several classes of T cells including follicular B helper T cells (TFH). The protein has been shown to bind PVR with high affinity; this binding is thought to assist i nteractions between TFH and dendritic cells to regulate T cell dependent B cell responses.[provided by RefSeq, Sep 2009] | 3 | 114294028 | 114310288 | Human | 59 | symbol , COSMIC , Human Proteome Map | gene, protein-coding, VALIDATED [RefSeq] |
| 2294384 | Tigit | T cell immunoreceptor with Ig and ITIM domains | Enables signaling receptor binding activity. Acts upstream of or within negative regulation of T cell activation. Predicted to be located in plasma membrane. Predicted to be active in cell surface. Orthologous to human TIGIT (T cell immunoreceptor with Ig and IT IM domains). [provided by Alliance of Genome Resources, Apr 2025] | 16 | 43469224 | 43485494 | Mouse | 67 | symbol , PhenoGen , description | gene, protein-coding, VALIDATED [RefSeq] |
| 9004566 | Tigit | T cell immunoreceptor with Ig and ITIM domains | ENCODES a protein that exhibits identical protein binding (ortholog); signaling receptor activity (ortholog); signaling receptor binding (ortholog); INVOLVED IN negative regulation of interleukin-12 production (ortholog); negative regulation of natural killer cell mediated cytotoxicity (ortholog); n egative regulation of T cell activation (ortholog); FOUND IN cell surface (ortholog); plasma membrane (ortholog) | NW_004955427 | 14358326 | 14381074 | Chinchilla | 20 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 11930289 | TIGIT | T cell immunoreceptor with Ig and ITIM domains | ENCODES a protein that exhibits identical protein binding (inferred); signaling receptor activity (inferred); signaling receptor binding (inferred); INVOLVED IN negative regulation of T cell activation (ortholog); FOUND IN cell surface (inferred); plasma membrane (inferred) | 3 | 111424940 | 111441126 | Bonobo | 28 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12110163 | TIGIT | T cell immunoreceptor with Ig and ITIM domains | ENCODES a protein that exhibits identical protein binding (inferred); signaling receptor activity (inferred); signaling receptor binding (inferred); INVOLVED IN negative regulation of T cell activation (ortholog); FOUND IN cell surface (inferred); plasma membrane (inferred) | 33 | 18484106 | 18501517 | Dog | 28 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12536668 | Tigit | T cell immunoreceptor with Ig and ITIM domains | ENCODES a protein that exhibits identical protein binding (inferred); signaling receptor activity (inferred); signaling receptor binding (inferred); INVOLVED IN negative regulation of T cell activation (ortholog); FOUND IN cell surface (inferred); plasma membrane (inferred) | NW_004936536 | 1731352 | 1746843 | Squirrel | 28 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 20866297 | TIGIT | T cell immunoreceptor with Ig and ITIM domains | ENCODES a protein that exhibits identical protein binding (inferred); signaling receptor activity (inferred); signaling receptor binding (inferred); INVOLVED IN negative regulation of interleukin-12 production (inferred); negative regulation of natural killer cell mediated cytotoxicity (inferred); n egative regulation of T cell activation (inferred); FOUND IN cell surface (inferred); plasma membrane (inferred) | | | | Green Monkey | 18 | symbol | gene, protein-coding |
| 18933117 | Tigit | T cell immunoreceptor with Ig and ITIM domains | ENCODES a protein that exhibits identical protein binding (ortholog); signaling receptor activity (ortholog); signaling receptor binding (ortholog); INVOLVED IN negative regulation of interleukin-12 production (ortholog); negative regulation of natural killer cell mediated cytotoxicity (ortholog); n egative regulation of T cell activation (ortholog); FOUND IN cell surface (ortholog); plasma membrane (ortholog) | | | | Naked Mole-Rat | 20 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 14197363 | TIGIT | T cell immunoreceptor with Ig and ITIM domains | ENCODES a protein that exhibits identical protein binding (inferred); signaling receptor activity (inferred); signaling receptor binding (inferred); INVOLVED IN negative regulation of T cell activation (ortholog); FOUND IN cell surface (inferred); plasma membrane (inferred); INTERACTS WITH deoxyniva lenol | | | | Pig | 29 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18342490 | TIGIT | T cell immunoreceptor with Ig and ITIM domains | ENCODES a protein that exhibits identical protein binding (ortholog); signaling receptor activity (ortholog); signaling receptor binding (ortholog); INVOLVED IN negative regulation of interleukin-12 production (ortholog); negative regulation of natural killer cell mediated cytotoxicity (ortholog); n egative regulation of T cell activation (ortholog); FOUND IN cell surface (ortholog); plasma membrane (ortholog) | | | | Green Monkey | 20 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 625856120 | Tigit | T cell immunoreceptor with Ig and ITIM domains | ENCODES a protein that exhibits identical protein binding (ortholog); signaling receptor activity (ortholog); signaling receptor binding (ortholog); INVOLVED IN negative regulation of interleukin-12 production (ortholog); negative regulation of natural killer cell mediated cytotoxicity (ortholog); n egative regulation of T cell activation (ortholog); FOUND IN cell surface (ortholog); plasma membrane (ortholog) | | | | Black Rat | 20 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 626183404 | tigit | | | | | | Tropical Clawed Frog | | symbol | gene, null |
