The protein encoded by this gene is a heat stable, nuclear protein and functions as a molecular chaperone. It is thought to regulate dimerization, DNA binding, and transcriptional activity of basic region-leucine zipper (bZIP) proteins. [provided by RefSeq, Jul 2008]
Enables several functions, including RNA binding activity; RNA folding chaperone; and single-stranded DNA binding activity. Predicted to be involved in mRNA export from nucleus. Predicted to be located in cytoplasm. Predicted to be part of catalytic step 2 spliceosome; exon-exon junction complex; an
d transcription export complex. Predicted to be active in nucleus. Predicted to colocalize with chromosome, telomeric region. Is expressed in several structures, including branchial arch; central nervous system; future brain; genitourinary system; and sensory organ. Orthologous to human ALYREF (Aly/REF export factor). [provided by Alliance of Genome Resources, Jul 2025]
ENCODES a protein that exhibits C5-methylcytidine-containing RNA reader activity (ortholog); molecular adaptor activity (ortholog); RNA binding (ortholog); INVOLVED IN mRNA export from nucleus (ortholog); mRNA metabolic process (ortholog); RNA export from nucleus (ortholog); PARTICIPATES IN NXF1-NXT
ENCODES a protein that exhibits C5-methylcytidine-containing RNA reader activity (ortholog); molecular adaptor activity (ortholog); RNA folding chaperone (ortholog); INVOLVED IN mRNA metabolic process (ortholog); RNA export from nucleus (ortholog); PARTICIPATES IN NXF1-NXT1 export pathway; ASSOCIATE
D WITH basal cell carcinoma (ortholog); human immunodeficiency virus infectious disease (ortholog); FOUND IN catalytic step 2 spliceosome (ortholog); chromosome, telomeric region (ortholog); cytoplasm (ortholog)