| 1321047 | TBC1D5 | TBC1 domain family member 5 | Enables AP-2 adaptor complex binding activity and retromer complex binding activity. Involved in several processes, including macroautophagy; positive regulation of receptor internalization; and retrograde transport, endosome to Golgi. Located in several cellular components, including Atg1/ULK1 kina se complex; autophagosome; and cytoplasmic vesicle membrane. Part of retromer complex. [provided by Alliance of Genome Resources, Jul 2025] | 3 | 17157162 | 17742631 | Human | 125 | symbol , COSMIC , Human Proteome Map | gene, protein-coding, VALIDATED [RefSeq] |
| 1321048 | Tbc1d5 | TBC1 domain family, member 5 | Predicted to enable AP-2 adaptor complex binding activity; GTPase activator activity; and retromer complex binding activity. Predicted to be involved in several processes, including macroautophagy; positive regulation of receptor internalization; and retrograde transport, endosome to Golgi. Predicte d to be located in autophagosome. Predicted to be part of AP-2 adaptor complex; Atg1/ULK1 kinase complex; and retromer complex. Predicted to be active in Golgi apparatus and endosome membrane. Orthologous to human TBC1D5 (TBC1 domain family member 5). [provided by Alliance of Genome Resources, Jul 2025] | 17 | 51040155 | 51488228 | Mouse | 130 | symbol , PhenoGen , description | gene, protein-coding, VALIDATED [RefSeq] |
| 1561626 | Tbc1d5 | TBC1 domain family, member 5 | ENCODES a protein that exhibits AP-2 adaptor complex binding (ortholog); protein-containing complex binding (ortholog); retromer complex binding (ortholog); INVOLVED IN autophagy (ortholog); macroautophagy (ortholog); positive regulation of receptor internalization (ortholog); PARTICIPATES IN retrom er-mediated pathway; FOUND IN AP-2 adaptor complex (ortholog); Atg1/ULK1 kinase complex (ortholog); autophagosome (ortholog); INTERACTS WITH 1,3-dinitrobenzene; 17beta-estradiol; 2,5-hexanedione | 9 | 3740032 | 4256971 | Rat | 111 | symbol , PhenoGen | gene, protein-coding, VALIDATED [RefSeq] |
| 9002078 | Tbc1d5 | TBC1 domain family member 5 | ENCODES a protein that exhibits AP-2 adaptor complex binding (ortholog); protein-containing complex binding (ortholog); retromer complex binding (ortholog); INVOLVED IN autophagy (ortholog); macroautophagy (ortholog); positive regulation of receptor internalization (ortholog); PARTICIPATES IN retrom er-mediated pathway; FOUND IN AP-2 adaptor complex (ortholog); Atg1/ULK1 kinase complex (ortholog); autophagosome (ortholog) | NW_004955430 | 9411865 | 9966710 | Chinchilla | 30 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 11967335 | TBC1D5 | TBC1 domain family member 5 | ENCODES a protein that exhibits AP-2 adaptor complex binding (inferred); GTPase activator activity (inferred); protein-containing complex binding (inferred); INVOLVED IN regulation of cilium assembly (ortholog); PARTICIPATES IN retromer-mediated pathway; FOUND IN AP-2 adaptor complex (inferred); Atg 1/ULK1 kinase complex (inferred); autophagosome (inferred) | 3 | 17080589 | 17664776 | Bonobo | 39 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12335146 | TBC1D5 | TBC1 domain family member 5 | ENCODES a protein that exhibits AP-2 adaptor complex binding (inferred); GTPase activator activity (inferred); protein-containing complex binding (inferred); INVOLVED IN regulation of cilium assembly (ortholog); PARTICIPATES IN retromer-mediated pathway; FOUND IN AP-2 adaptor complex (inferred); Atg 1/ULK1 kinase complex (inferred); autophagosome (inferred) | 23 | 25206825 | 25758026 | Dog | 43 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12476465 | Tbc1d5 | TBC1 domain family member 5 | ENCODES a protein that exhibits AP-2 adaptor complex binding (inferred); GTPase activator activity (inferred); protein-containing complex binding (inferred); INVOLVED IN regulation of cilium assembly (ortholog); PARTICIPATES IN retromer-mediated pathway; FOUND IN AP-2 adaptor complex (inferred); Atg 1/ULK1 kinase complex (inferred); autophagosome (inferred) | NW_004936473 | 9868657 | 10294554 | Squirrel | 39 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18713302 | TBC1D5 | TBC1 domain family member 5 | ENCODES a protein that exhibits AP-2 adaptor complex binding (inferred); GTPase activator activity (inferred); protein-containing complex binding (inferred); INVOLVED IN regulation of cilium assembly (ortholog); PARTICIPATES IN retromer-mediated pathway; FOUND IN AP-2 adaptor complex (inferred); Atg 1/ULK1 kinase complex (inferred); autophagosome (inferred) | | | | Green Monkey | 39 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18916740 | Tbc1d5 | TBC1 domain family member 5 | ENCODES a protein that exhibits AP-2 adaptor complex binding (ortholog); protein-containing complex binding (ortholog); retromer complex binding (ortholog); INVOLVED IN macroautophagy (ortholog); positive regulation of receptor internalization (ortholog); regulation of cilium assembly (ortholog); PA RTICIPATES IN retromer-mediated pathway; FOUND IN AP-2 adaptor complex (ortholog); Atg1/ULK1 kinase complex (ortholog); retromer complex (ortholog) | | | | Naked Mole-Rat | 35 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 14091805 | TBC1D5 | TBC1 domain family member 5 | ENCODES a protein that exhibits AP-2 adaptor complex binding (inferred); GTPase activator activity (inferred); protein-containing complex binding (inferred); INVOLVED IN regulation of cilium assembly (ortholog); PARTICIPATES IN retromer-mediated pathway; FOUND IN AP-2 adaptor complex (inferred); Atg 1/ULK1 kinase complex (inferred); autophagosome (inferred) | | | | Pig | 43 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 155253894 | tbc1d5 | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 14377084 | TBC1D5 | | | | | | Fly | | symbol | gene, null |
| 625948650 | Tbc1d5 | TBC1 domain family member 5 | ENCODES a protein that exhibits AP-2 adaptor complex binding (ortholog); protein-containing complex binding (ortholog); retromer complex binding (ortholog); INVOLVED IN autophagy (ortholog); macroautophagy (ortholog); positive regulation of receptor internalization (ortholog); PARTICIPATES IN retrom er-mediated pathway; FOUND IN AP-2 adaptor complex (ortholog); Atg1/ULK1 kinase complex (ortholog); autophagosome (ortholog) | | | | Black Rat | 30 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 155253893 | tbc1d5.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 1592089 | Tbc1d5-ps1 | TBC1 domain family, member 5, pseudogene 1 | | 5 | 116680346 | 116688765 | Rat | | symbol , PhenoGen | gene, pseudo, MODEL [RefSeq] |
| 16570923 | AC090644.1 | Novel transcript, antisense to TBC1D5 | | | | | Human | | name | gene, lncrna |