| 619967 | Stxbp2 | syntaxin binding protein 2 | ENCODES a protein that exhibits syntaxin binding; syntaxin-1 binding; syntaxin-3 binding; INVOLVED IN positive regulation of mast cell degranulation; regulation of mast cell degranulation; response to acidic pH; ASSOCIATED WITH blood platelet disease (ortholog); carotid artery thrombosis (ortholog); Chediak-Higashi syndrome (ortholog); FOUND IN apical plasma membrane; lamellipodium; protein-containing complex; INTERACTS WITH acrylamide; ammonium chloride; bisphenol A | 12 | 6487265 | 6498351 | Rat | 129 | symbol , PhenoGen | gene, protein-coding, VALIDATED [RefSeq] |
| 733592 | STXBP2 | syntaxin binding protein 2 | This gene encodes a member of the STXBP/unc-18/SEC1 family. The encoded protein is involved in intracellular trafficking, control of SNARE (soluble NSF attachment protein receptor) complex assembly, and the release of cytotoxic granules by natural killer cells. Mutations in this gene are associated with familial hemophagocytic lymphohistiocytosis. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene. [provided by RefSeq, Jan 2013] | 19 | 7629793 | 7647873 | Human | 265 | symbol , COSMIC , Human Proteome Map | gene, protein-coding, REVIEWED [RefSeq] |
| 733593 | Stxbp2 | syntaxin binding protein 2 | Enables syntaxin-1 binding activity and syntaxin-3 binding activity. Acts upstream of or within cellular response to type II interferon and exocytosis. Located in apical plasma membrane; phagocytic vesicle; and zymogen granule membrane. Is expressed in several structures, including brain; gut; respi ratory system; sensory organ; and urinary system. Human ortholog(s) of this gene implicated in familial hemophagocytic lymphohistiocytosis 5. Orthologous to human STXBP2 (syntaxin binding protein 2). [provided by Alliance of Genome Resources, Jul 2025] | 8 | 3680960 | 3693998 | Mouse | 133 | symbol , PhenoGen , description | gene, protein-coding, VALIDATED [RefSeq] |
| 8760258 | Stxbp2 | syntaxin binding protein 2 | ENCODES a protein that exhibits syntaxin binding (ortholog); syntaxin-1 binding (ortholog); syntaxin-3 binding (ortholog); INVOLVED IN cellular response to type II interferon (ortholog); exocytosis (ortholog); leukocyte mediated cytotoxicity (ortholog); ASSOCIATED WITH blood platelet disease (orthol og); carotid artery thrombosis (ortholog); Chediak-Higashi syndrome (ortholog); FOUND IN apical plasma membrane (ortholog); azurophil granule (ortholog); cytolytic granule (ortholog) | NW_004955563 | 1617621 | 1624441 | Chinchilla | 45 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12013219 | STXBP2 | syntaxin binding protein 2 | ENCODES a protein that exhibits syntaxin binding (ortholog); syntaxin-1 binding (ortholog); syntaxin-3 binding (ortholog); INVOLVED IN cellular response to type II interferon (ortholog); exocytosis (ortholog); positive regulation of mast cell degranulation (ortholog); ASSOCIATED WITH blood platelet disease (ortholog); carotid artery thrombosis (ortholog); Chediak-Higashi syndrome (ortholog); FOUND IN apical plasma membrane (ortholog); lamellipodium (ortholog); plasma membrane (ortholog) | 19 | 6926833 | 6937385 | Bonobo | 47 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12344838 | STXBP2 | syntaxin binding protein 2 | ENCODES a protein that exhibits syntaxin binding (ortholog); syntaxin-1 binding (ortholog); syntaxin-3 binding (ortholog); INVOLVED IN cellular response to type II interferon (ortholog); exocytosis (ortholog); neutrophil degranulation (ortholog); ASSOCIATED WITH blood platelet disease (ortholog); ca rotid artery thrombosis (ortholog); Chediak-Higashi syndrome (ortholog); FOUND IN apical plasma membrane (ortholog); azurophil granule (ortholog); cytosol (ortholog) | 20 | 52413174 | 52421525 | Dog | 58 | symbol | gene, protein-coding, PROVISIONAL [RefSeq] |
| 12613237 | Stxbp2 | syntaxin binding protein 2 | ENCODES a protein that exhibits syntaxin binding (ortholog); syntaxin-1 binding (ortholog); syntaxin-3 binding (ortholog); INVOLVED IN cellular response to type II interferon (ortholog); exocytosis (ortholog); positive regulation of mast cell degranulation (ortholog); ASSOCIATED WITH blood platelet disease (ortholog); carotid artery thrombosis (ortholog); Chediak-Higashi syndrome (ortholog); FOUND IN apical plasma membrane (ortholog); lamellipodium (ortholog); plasma membrane (ortholog) | NW_004936588 | 4688221 | 4696075 | Squirrel | 46 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18917502 | Stxbp2 | syntaxin binding protein 2 | ENCODES a protein that exhibits syntaxin binding (ortholog); syntaxin-1 binding (ortholog); syntaxin-3 binding (ortholog); INVOLVED IN cellular response to type II interferon (ortholog); exocytosis (ortholog); leukocyte mediated cytotoxicity (ortholog); ASSOCIATED WITH blood platelet disease (orthol og); carotid artery thrombosis (ortholog); Chediak-Higashi syndrome (ortholog); FOUND IN apical plasma membrane (ortholog); azurophil granule (ortholog); cytolytic granule (ortholog) | | | | Naked Mole-Rat | 47 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 626012380 | Stxbp2 | syntaxin binding protein 2 | ENCODES a protein that exhibits syntaxin binding (ortholog); syntaxin-1 binding (ortholog); syntaxin-3 binding (ortholog); INVOLVED IN cellular response to type II interferon (ortholog); exocytosis (ortholog); leukocyte mediated cytotoxicity (ortholog); ASSOCIATED WITH blood platelet disease (orthol og); carotid artery thrombosis (ortholog); Chediak-Higashi syndrome (ortholog); FOUND IN apical plasma membrane (ortholog); azurophil granule (ortholog); cytolytic granule (ortholog) | | | | Black Rat | 43 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18537352 | STXBP2 | syntaxin binding protein 2 | ENCODES a protein that exhibits syntaxin binding (ortholog); syntaxin-1 binding (ortholog); syntaxin-3 binding (ortholog); INVOLVED IN cellular response to type II interferon (ortholog); exocytosis (ortholog); positive regulation of mast cell degranulation (ortholog); ASSOCIATED WITH blood platelet disease (ortholog); carotid artery thrombosis (ortholog); Chediak-Higashi syndrome (ortholog); FOUND IN apical plasma membrane (ortholog); lamellipodium (ortholog); plasma membrane (ortholog) | | | | Green Monkey | 47 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 13915052 | STXBP2 | syntaxin binding protein 2 | ENCODES a protein that exhibits syntaxin binding (ortholog); syntaxin-1 binding (ortholog); syntaxin-3 binding (ortholog); INVOLVED IN cellular response to type II interferon (ortholog); exocytosis (ortholog); positive regulation of mast cell degranulation (ortholog); ASSOCIATED WITH blood platelet disease (ortholog); carotid artery thrombosis (ortholog); Chediak-Higashi syndrome (ortholog); FOUND IN apical plasma membrane (ortholog); lamellipodium (ortholog); protein-containing complex (ortholog); INTERACTS WITH ethanol | | | | Pig | 60 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 155260167 | stxbp2 | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 626175102 | stxbp2.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 16564934 | AC008763.1 | novel transcript, antisense to STXBP2 | | | | | Human | | name | gene, lncrna |