ENCODES a protein that exhibits 7S RNA binding (ortholog); endoplasmic reticulum signal peptide binding (ortholog); GDP binding (ortholog); INVOLVED IN exocrine pancreas development (ortholog); granulocyte differentiation (ortholog); neutrophil chemotaxis (ortholog); ASSOCIATED WITH Desbuquois dyspl
asia (ortholog); genetic disease (ortholog); severe congenital neutropenia 8 (ortholog); FOUND IN cytoplasm (ortholog); nucleolus (ortholog); nucleus (ortholog); INTERACTS WITH 2,6-dinitrotoluene; 6-propyl-2-thiouracil; bisphenol A
Predicted to enable several functions, including 7S RNA binding activity; endoplasmic reticulum signal peptide binding activity; and guanyl ribonucleotide binding activity. Predicted to contribute to GTPase activity. Predicted to be involved in several processes, including SRP-dependent cotranslatio
nal protein targeting to membrane, translocation; exocrine pancreas development; and neutrophil chemotaxis. Predicted to act upstream of or within SRP-dependent cotranslational protein targeting to membrane. Predicted to be located in cytoplasm and nucleus. Predicted to be part of signal recognition particle, endoplasmic reticulum targeting. Predicted to be active in cytosol. Human ortholog(s) of this gene implicated in severe congenital neutropenia 8. Orthologous to human SRP54 (signal recognition particle 54). [provided by Alliance of Genome Resources, Jul 2025]