| 1305616 | Spag6 | sperm associated antigen 6 | INVOLVED IN cell projection organization (inferred); FOUND IN axoneme (ortholog); microtubule cytoskeleton (ortholog); sperm end piece (ortholog); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 6-propyl-2-thiouracil; amitrole | 17 | 86258418 | 86309922 | Rat | 77 | symbol , PhenoGen , old_gene_symbol | gene, protein-coding, PROVISIONAL [RefSeq] |
| 1313749 | SPAG6 | sperm associated antigen 6 | The correlation of anti-sperm antibodies with cases of unexplained infertility implicates a role for these antibodies in blocking fertilization. Improved diagnosis and treatment of immunologic infertility, as well as identification of proteins for targeted contraception, are dependent on the identif ication and characterization of relevant sperm antigens. The protein expressed by this gene is recognized by anti-sperm antibodies from an infertile man. This protein localizes to the tail of permeabilized human sperm and contains eight contiguous armadillo repeats, a motif known to mediate protein-protein interactions. Studies in mice suggest that this protein is involved in sperm flagellar motility and maintenance of the structural integrity of mature sperm. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011] | 10 | 22345496 | 22417610 | Human | 79 | symbol , COSMIC , Human Proteome Map | gene, protein-coding, REVIEWED [RefSeq] |
| 1620435 | Spag6 | sperm associated antigen 6 | Predicted to enable microtubule binding activity. Predicted to be involved in epithelial cilium movement involved in extracellular fluid movement and plasma membrane bounded cell projection organization. Predicted to be active in acrosomal vesicle; cytoskeleton; and sperm principal piece. Orthologou s to human SPAG6 (sperm associated antigen 6). [provided by Alliance of Genome Resources, Jul 2025] | 2 | 18698808 | 18754561 | Mouse | 78 | symbol , old_gene_name , PhenoGen , description , old_gene_symbol | gene, protein-coding, VALIDATED [RefSeq] |
| 8777928 | Spag6 | sperm associated antigen 6 | FOUND IN axoneme (ortholog); microtubule cytoskeleton (ortholog); sperm end piece (ortholog) | NW_004955429 | 625601 | 662804 | Chinchilla | 8 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 11768976 | SPAG6 | sperm associated antigen 6 | ENCODES a protein that exhibits microtubule binding (inferred); INVOLVED IN cell projection organization (inferred); cilium movement (inferred); epithelial cilium movement involved in extracellular fluid movement (inferred); FOUND IN acrosomal vesicle (inferred); axoneme (inferred); extracellular re gion (inferred) | 10 | 22502032 | 22574184 | Bonobo | 25 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12426656 | SPAG6 | sperm associated antigen 6 | INVOLVED IN cell projection organization (inferred); FOUND IN axoneme (inferred); extracellular region (inferred); microtubule (inferred) | 2 | 10737260 | 10804080 | Dog | 24 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12441781 | Spag6 | sperm associated antigen 6 | ENCODES a protein that exhibits microtubule binding (inferred); INVOLVED IN cell projection organization (inferred); cilium movement (inferred); epithelial cilium movement involved in extracellular fluid movement (inferred); FOUND IN acrosomal vesicle (inferred); axoneme (inferred); extracellular re gion (inferred) | NW_004936520 | 5628576 | 5693590 | Squirrel | 25 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18935169 | Spag6 | sperm associated antigen 6 | ENCODES a protein that exhibits microtubule binding (inferred); INVOLVED IN cell projection organization (inferred); cilium movement (inferred); epithelial cilium movement involved in extracellular fluid movement (inferred); FOUND IN sperm end piece (ortholog); sperm glycocalyx (ortholog); sperm mid piece (ortholog) | | | | Naked Mole-Rat | 22 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 625928787 | Spag6 | sperm associated antigen 6 | FOUND IN axoneme (ortholog); microtubule cytoskeleton (ortholog); sperm end piece (ortholog) | | | | Black Rat | 8 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 155252278 | spag6 | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 13904085 | SPAG6 | sperm associated antigen 6 | INVOLVED IN cell projection organization (inferred); FOUND IN axoneme (inferred); extracellular region (inferred); microtubule (inferred) | | | | Pig | 24 | symbol | gene, protein-coding, PROVISIONAL [RefSeq] |
| 18510005 | SPAG6 | sperm associated antigen 6 | ENCODES a protein that exhibits microtubule binding (inferred); INVOLVED IN cell projection organization (inferred); cilium movement (inferred); epithelial cilium movement involved in extracellular fluid movement (inferred); FOUND IN acrosomal vesicle (inferred); axoneme (inferred); extracellular re gion (inferred) | | | | Green Monkey | 25 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 155256360 | spag6.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 155253231 | spag6.S | | | | | | African Clawed Frog | | symbol | gene, null |
| 8953739 | LOC102016403 | uncharacterized LOC102016403 | | NW_004955429 | 6520317 | 6531549 | Chinchilla | | old_gene_symbol | gene, ncrna, MODEL [RefSeq] |
| 1310892 | Spag6l | sperm associated antigen 6-like | INVOLVED IN cell projection organization (inferred); FOUND IN axoneme (inferred); extracellular region (inferred); microtubule (inferred); INTERACTS WITH 17alpha-ethynylestradiol; amitrole; bisphenol A | 11 | 97677840 | 97773580 | Rat | 26 | symbol , PhenoGen , old_gene_symbol | gene, protein-coding, PROVISIONAL [RefSeq] |
| 1615147 | Spag6l | sperm associated antigen 6-like | Enables microtubule binding activity. Acts upstream of or within several processes, including epithelial cilium movement involved in extracellular fluid movement; plasma membrane bounded cell projection organization; and stress fiber assembly. Located in several cellular components, including cytosk eleton; lateral wall of outer hair cell; and sperm principal piece. Is expressed in cochlea. Orthologous to human SPAG6 (sperm associated antigen 6). [provided by Alliance of Genome Resources, Jul 2025] | 16 | 16570880 | 16647177 | Mouse | 36 | symbol , PhenoGen , description , old_gene_symbol | gene, protein-coding, VALIDATED [RefSeq] |
| 16555627 | AL513128.1 | novel transcript, sense overlapping SPAG6 | | | | | Human | | name | gene, lncrna |