| 620152 | Spag5 | sperm associated antigen 5 | ENCODES a protein that exhibits microtubule binding (ortholog); INVOLVED IN chromosome segregation (ortholog); establishment of spindle orientation (ortholog); mitotic sister chromatid segregation (ortholog); ASSOCIATED WITH cervical cancer (ortholog); COVID-19 (ortholog); Spontaneous Abortions (ort holog); FOUND IN centriolar satellite (ortholog); ciliary basal body (ortholog); ciliary rootlet (ortholog); INTERACTS WITH 1-naphthyl isothiocyanate; 17beta-estradiol; 17beta-estradiol 3-benzoate | 10 | 63693300 | 63714813 | Rat | 215 | symbol , PhenoGen | gene, protein-coding, PROVISIONAL [RefSeq] |
| 736242 | SPAG5 | sperm associated antigen 5 | This gene encodes a protein associated with the mitotic spindle apparatus. The encoded protein may be involved in the functional and dynamic regulation of mitotic spindles. [provided by RefSeq, Jul 2008] | 17 | 28577574 | 28599025 | Human | 220 | symbol , COSMIC , Human Proteome Map | gene, protein-coding, REVIEWED [RefSeq] |
| 736243 | Spag5 | sperm associated antigen 5 | Predicted to enable microtubule binding activity. Acts upstream of or within establishment of spindle orientation. Located in ciliary basal body; ciliary rootlet; and mitotic spindle. Is expressed in several structures, including alimentary system; brain; genitourinary system; integumental system; a nd sensory organ. Orthologous to human SPAG5 (sperm associated antigen 5). [provided by Alliance of Genome Resources, Jul 2025] | 11 | 78192412 | 78213283 | Mouse | 251 | symbol , PhenoGen , description | gene, protein-coding, VALIDATED [RefSeq] |
| 8953327 | Spag5 | sperm associated antigen 5 | ENCODES a protein that exhibits microtubule binding (ortholog); INVOLVED IN chromosome segregation (ortholog); establishment of spindle orientation (ortholog); mitotic sister chromatid segregation (ortholog); ASSOCIATED WITH cervical cancer (ortholog); COVID-19 (ortholog); Spontaneous Abortions (ort holog); FOUND IN centriolar satellite (ortholog); ciliary basal body (ortholog); ciliary rootlet (ortholog) | NW_004955481 | 4558748 | 4576320 | Chinchilla | 40 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 11731734 | SPAG5 | sperm associated antigen 5 | ENCODES a protein that exhibits microtubule binding (inferred); INVOLVED IN establishment of spindle orientation (ortholog); ASSOCIATED WITH cervical cancer (ortholog); COVID-19 (ortholog); Spontaneous Abortions (ortholog); FOUND IN centriolar satellite (inferred); ciliary basal body (inferred); cil iary rootlet (inferred) | 17 | 28176288 | 28198493 | Bonobo | 41 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12363892 | SPAG5 | sperm associated antigen 5 | ENCODES a protein that exhibits microtubule binding (inferred); INVOLVED IN establishment of spindle orientation (ortholog); ASSOCIATED WITH cervical cancer (ortholog); COVID-19 (ortholog); Spontaneous Abortions (ortholog); FOUND IN centriolar satellite (inferred); ciliary basal body (inferred); cil iary rootlet (inferred) | 9 | 42783224 | 42804568 | Dog | 41 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12599106 | Spag5 | sperm associated antigen 5 | ENCODES a protein that exhibits microtubule binding (inferred); INVOLVED IN establishment of spindle orientation (ortholog); ASSOCIATED WITH cervical cancer (ortholog); COVID-19 (ortholog); Spontaneous Abortions (ortholog); FOUND IN centriolar satellite (inferred); ciliary basal body (inferred); cil iary rootlet (inferred) | NW_004936538 | 4803536 | 4821034 | Squirrel | 41 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 13883760 | SPAG5 | sperm associated antigen 5 | ENCODES a protein that exhibits microtubule binding (inferred); INVOLVED IN establishment of spindle orientation (ortholog); ASSOCIATED WITH cervical cancer (ortholog); COVID-19 (ortholog); Spontaneous Abortions (ortholog); FOUND IN centriolar satellite (inferred); ciliary basal body (inferred); cil iary rootlet (inferred) | | | | Pig | 41 | symbol | gene, protein-coding, PROVISIONAL [RefSeq] |
| 18564257 | SPAG5 | sperm associated antigen 5 | ENCODES a protein that exhibits microtubule binding (inferred); INVOLVED IN establishment of spindle orientation (ortholog); ASSOCIATED WITH cervical cancer (ortholog); COVID-19 (ortholog); Spontaneous Abortions (ortholog); FOUND IN centriolar satellite (inferred); ciliary basal body (inferred); cil iary rootlet (inferred) | | | | Green Monkey | 41 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18921958 | Spag5 | sperm associated antigen 5 | ENCODES a protein that exhibits microtubule binding (ortholog); INVOLVED IN chromosome segregation (ortholog); establishment of spindle orientation (ortholog); mitotic sister chromatid segregation (ortholog); ASSOCIATED WITH cervical cancer (ortholog); COVID-19 (ortholog); Spontaneous Abortions (ort holog); FOUND IN centriolar satellite (ortholog); ciliary basal body (ortholog); ciliary rootlet (ortholog) | | | | Naked Mole-Rat | 41 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 405856798 | spag5 | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 405864533 | spag5 | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 598150809 | spag5 | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 626053031 | Spag5 | sperm associated antigen 5 | ENCODES a protein that exhibits microtubule binding (ortholog); INVOLVED IN chromosome segregation (ortholog); establishment of spindle orientation (ortholog); mitotic sister chromatid segregation (ortholog); ASSOCIATED WITH cervical cancer (ortholog); COVID-19 (ortholog); Spontaneous Abortions (ort holog); FOUND IN centriolar satellite (ortholog); ciliary basal body (ortholog); ciliary rootlet (ortholog) | | | | Black Rat | 40 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 405856797 | spag5.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 405860137 | spag5.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 405860337 | spag5.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 405864534 | spag5.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 626181072 | spag5.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 5490491 | SPAG5-AS1 | SPAG5 antisense RNA 1 | INTERACTS WITH aristolochic acid A; cisplatin; rotenone | 17 | 28599133 | 28617377 | Human | 4 | symbol , COSMIC , name , Human Proteome Map | gene, ncrna, VALIDATED [RefSeq] |
| 1614389 | Knstrn | kinetochore-localized astrin/SPAG5 binding | Predicted to enable microtubule plus-end binding activity and protein homodimerization activity. Predicted to be involved in several processes, including cellular response to epidermal growth factor stimulus; mitotic sister chromatid segregation; and regulation of attachment of spindle microtubules to kinetochore. Predicted to be located in microtubule organizing center; plasma membrane; and ruffle. Predicted to be active in kinetochore and microtubule cytoskeleton. Is expressed in cerebral cortex ventricular layer. Human ortholog(s) of this gene implicated in actinic keratosis and skin squamous cell carcinoma. Orthologous to human KNSTRN (kinetochore localized astrin (SPAG5) binding protein). [provided by Alliance of Genome Resources, Jul 2025] | 2 | 118644470 | 118667691 | Mouse | 224 | old_gene_name , name , description | gene, protein-coding, VALIDATED [RefSeq] |
| 1303240 | Knstrn | kinetochore-localized astrin/SPAG5 binding protein | ENCODES a protein that exhibits microtubule plus-end binding (ortholog); protein homodimerization activity (ortholog); INVOLVED IN cell migration (ortholog); cellular response to epidermal growth factor stimulus (ortholog); chromosome segregation (ortholog); ASSOCIATED WITH actinic keratosis (orthol og); COVID-19 (ortholog); Roifman-Chitayat Syndrome (ortholog); FOUND IN centriolar satellite (ortholog); kinetochore (ortholog); microtubule organizing center (ortholog); INTERACTS WITH 1,2-dimethylhydrazine; 1-naphthyl isothiocyanate; 17alpha-ethynylestradiol | 3 | 126254633 | 126274412 | Rat | 204 | old_gene_name , name | gene, protein-coding, PROVISIONAL [RefSeq] |
| 1344647 | KNSTRN | kinetochore localized astrin (SPAG5) binding protein | Enables microtubule plus-end binding activity and protein homodimerization activity. Involved in several processes, including cellular response to epidermal growth factor stimulus; mitotic sister chromatid segregation; and regulation of attachment of spindle microtubules to kinetochore. Located in s everal cellular components, including kinetochore; microtubule cytoskeleton; and ruffle. Implicated in actinic keratosis and skin squamous cell carcinoma. [provided by Alliance of Genome Resources, Jul 2025] | 15 | 40382721 | 40394288 | Human | 263 | old_gene_name , name | gene, protein-coding, VALIDATED [RefSeq] |
| 8781628 | Knstrn | kinetochore localized astrin (SPAG5) binding protein | ENCODES a protein that exhibits microtubule plus-end binding (ortholog); protein homodimerization activity (ortholog); INVOLVED IN cell migration (ortholog); cellular response to epidermal growth factor stimulus (ortholog); chromosome segregation (ortholog); ASSOCIATED WITH actinic keratosis (orthol og); COVID-19 (ortholog); Roifman-Chitayat Syndrome (ortholog); FOUND IN centriolar satellite (ortholog); kinetochore (ortholog); microtubule organizing center (ortholog) | NW_004955416 | 7311483 | 7322272 | Chinchilla | 27 | name | gene, protein-coding, MODEL [RefSeq] |
| 11793438 | KNSTRN | kinetochore localized astrin (SPAG5) binding protein | ENCODES a protein that exhibits microtubule plus-end binding (ortholog); protein homodimerization activity (ortholog); INVOLVED IN cell migration (ortholog); cellular response to epidermal growth factor stimulus (ortholog); chromosome segregation (ortholog); ASSOCIATED WITH actinic keratosis (orthol og); COVID-19 (ortholog); Roifman-Chitayat Syndrome (ortholog); FOUND IN centriolar satellite (ortholog); kinetochore (ortholog); microtubule organizing center (ortholog) | 15 | 19316854 | 19328425 | Bonobo | 27 | name | gene, protein-coding, MODEL [RefSeq] |
| 12366236 | KNSTRN | kinetochore localized astrin (SPAG5) binding protein | ENCODES a protein that exhibits microtubule plus-end binding (ortholog); protein homodimerization activity (ortholog); INVOLVED IN cell migration (ortholog); cellular response to epidermal growth factor stimulus (ortholog); microtubule cytoskeleton organization (ortholog); ASSOCIATED WITH actinic ke ratosis (ortholog); COVID-19 (ortholog); Roifman-Chitayat Syndrome (ortholog); FOUND IN centriolar satellite (ortholog); microtubule organizing center (ortholog); microtubule plus-end (ortholog) | 30 | 7562738 | 7573514 | Dog | 41 | name | gene, protein-coding, MODEL [RefSeq] |
| 12728322 | Knstrn | kinetochore localized astrin (SPAG5) binding protein | ENCODES a protein that exhibits microtubule plus-end binding (inferred); protein homodimerization activity (inferred); INVOLVED IN cell migration (inferred); cellular response to epidermal growth factor stimulus (inferred); chromosome segregation (inferred); ASSOCIATED WITH actinic keratosis (orthol og); COVID-19 (ortholog); Roifman-Chitayat Syndrome (ortholog); FOUND IN centriolar satellite (inferred); kinetochore (inferred); microtubule organizing center (inferred) | NW_004936471 | 3838507 | 3849521 | Squirrel | 38 | name | gene, protein-coding, MODEL [RefSeq] |
| 13864269 | KNSTRN | kinetochore localized astrin (SPAG5) binding protein | ENCODES a protein that exhibits 3-methylbutanoyl-CoA dehydrogenase activity (inferred); acyl-CoA dehydrogenase activity (inferred); flavin adenine dinucleotide binding (inferred); INVOLVED IN cell migration (inferred); cellular response to epidermal growth factor stimulus (inferred); chromosome segr egation (inferred); ASSOCIATED WITH actinic keratosis (ortholog); COVID-19 (ortholog); Roifman-Chitayat Syndrome (ortholog); FOUND IN centriolar satellite (inferred); kinetochore (inferred); microtubule organizing center (inferred) | | | | Pig | 45 | name | gene, protein-coding, MODEL [RefSeq] |
| 18338516 | KNSTRN | kinetochore localized astrin (SPAG5) binding protein | ENCODES a protein that exhibits microtubule plus-end binding (inferred); protein homodimerization activity (inferred); INVOLVED IN cell migration (inferred); cellular response to epidermal growth factor stimulus (inferred); chromosome segregation (inferred); ASSOCIATED WITH actinic keratosis (orthol og); COVID-19 (ortholog); Roifman-Chitayat Syndrome (ortholog); FOUND IN centriolar satellite (inferred); kinetochore (inferred); microtubule organizing center (inferred) | | | | Green Monkey | 38 | name | gene, protein-coding, MODEL [RefSeq] |
| 152178169 | KNSTRN | kinetochore localized astrin (SPAG5) binding protein | | | | | Naked Mole-Rat | | name | gene, protein-coding |
| 625925465 | Knstrn | kinetochore localized astrin (SPAG5) binding protein | ENCODES a protein that exhibits microtubule plus-end binding (ortholog); protein homodimerization activity (ortholog); INVOLVED IN cell migration (ortholog); cellular response to epidermal growth factor stimulus (ortholog); chromosome segregation (ortholog); ASSOCIATED WITH actinic keratosis (orthol og); COVID-19 (ortholog); Roifman-Chitayat Syndrome (ortholog); FOUND IN centriolar satellite (ortholog); kinetochore (ortholog); microtubule organizing center (ortholog) | | | | Black Rat | 27 | name | gene, protein-coding, MODEL [RefSeq] |
| 18904603 | LOC101710885 | isovaleryl-CoA dehydrogenase, mitochondrial | ENCODES a protein that exhibits 3-methylbutanoyl-CoA dehydrogenase activity (inferred); acyl-CoA dehydrogenase activity (inferred); flavin adenine dinucleotide binding (inferred); INVOLVED IN carboxylic acid catabolic process (inferred); chromosome segregation (inferred); L-leucine catabolic process (inferred); FOUND IN centriolar satellite (inferred); kinetochore (inferred); microtubule plus-end (inferred) | | | | Naked Mole-Rat | 28 | old_gene_name | gene, protein-coding, MODEL [RefSeq] |