| 1321977 | SNW1 | SNW domain containing 1 | This gene, a member of the SNW gene family, encodes a coactivator that enhances transcription from some Pol II promoters. This coactivator can bind to the ligand-binding domain of the vitamin D receptor and to retinoid receptors to enhance vitamin D-, retinoic acid-, estrogen-, and glucocorticoid-me diated gene expression. It can also function as a splicing factor by interacting with poly(A)-binding protein 2 to directly control the expression of muscle-specific genes at the transcriptional level. Finally, the protein may be involved in oncogenesis since it interacts with a region of SKI oncoproteins that is required for transforming activity. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2016] | 14 | 77717599 | 77761156 | Human | 155 | symbol , COSMIC , Human Proteome Map | gene, protein-coding, REVIEWED [RefSeq] |
| 1561926 | Snw1 | SNW domain containing 1 | ENCODES a protein that exhibits enzyme binding (ortholog); Notch binding (ortholog); nuclear androgen receptor binding (ortholog); INVOLVED IN Schwann cell proliferation; cellular response to retinoic acid (ortholog); host-mediated activation of viral transcription (ortholog); PARTICIPATES IN splice osome pathway; Notch signaling pathway; ASSOCIATED WITH Brain Injuries; Optic Nerve Injuries; sciatic neuropathy; FOUND IN chromatin; SMAD protein complex; catalytic step 2 spliceosome (ortholog); INTERACTS WITH 17alpha-ethynylestradiol; bisphenol A; cobalt dichloride | 6 | 112826374 | 112850459 | Rat | 120 | symbol , old_gene_name , PhenoGen | gene, protein-coding, PROVISIONAL [RefSeq] |
| 1624001 | Snw1 | SNW domain containing 1 | Predicted to enable several functions, including Notch binding activity; nuclear receptor binding activity; and transcription coregulator activity. Involved in cellular response to retinoic acid and positive regulation of neurogenesis. Acts upstream of or within skeletal muscle cell differentiation. Predicted to be located in chromatin; nuclear matrix; and nuclear speck. Predicted to be part of SMAD protein complex; U2-type catalytic step 2 spliceosome; and cyclin/CDK positive transcription elongation factor complex. Is expressed in several structures, including alimentary system; brain; genitourinary system; respiratory system; and sensory organ. Human ortholog(s) of this gene implicated in breast cancer and pancreatic cancer. Orthologous to human SNW1 (SNW domain containing 1). [provided by Alliance of Genome Resources, Jul 2025] | 12 | 87496680 | 87519069 | Mouse | 148 | symbol , PhenoGen , description | gene, protein-coding, VALIDATED [RefSeq] |
| 8904162 | Snw1 | SNW domain containing 1 | ENCODES a protein that exhibits enzyme binding (ortholog); Notch binding (ortholog); nuclear androgen receptor binding (ortholog); INVOLVED IN cellular response to retinoic acid (ortholog); host-mediated activation of viral transcription (ortholog); intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator (ortholog); PARTICIPATES IN spliceosome pathway; ASSOCIATED WITH Brain Injuries (ortholog); breast cancer (ortholog); breast carcinoma (ortholog); FOUND IN catalytic step 2 spliceosome (ortholog); chromatin (ortholog); cyclin/CDK positive transcription elongation factor complex (ortholog) | NW_004955438 | 1561562 | 1601492 | Chinchilla | 88 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 11941464 | SNW1 | SNW domain containing 1 | ENCODES a protein that exhibits enzyme binding (ortholog); Notch binding (ortholog); nuclear androgen receptor binding (ortholog); INVOLVED IN cellular response to retinoic acid (ortholog); host-mediated activation of viral transcription (ortholog); intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator (ortholog); PARTICIPATES IN spliceosome pathway; ASSOCIATED WITH Brain Injuries (ortholog); breast cancer (ortholog); breast carcinoma (ortholog); FOUND IN catalytic step 2 spliceosome (ortholog); chromatin (ortholog); cyclin/CDK positive transcription elongation factor complex (ortholog) | 14 | 58271830 | 58315773 | Bonobo | 92 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12058691 | SNW1 | SNW domain containing 1 | ENCODES a protein that exhibits enzyme binding (ortholog); Notch binding (ortholog); nuclear androgen receptor binding (ortholog); INVOLVED IN cellular response to retinoic acid (ortholog); host-mediated activation of viral transcription (ortholog); intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator (ortholog); PARTICIPATES IN spliceosome pathway; ASSOCIATED WITH Brain Injuries (ortholog); breast cancer (ortholog); breast carcinoma (ortholog); FOUND IN catalytic step 2 spliceosome (ortholog); chromatin (ortholog); cyclin/CDK positive transcription elongation factor complex (ortholog) | 8 | 50478924 | 50512360 | Dog | 92 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12491953 | Snw1 | SNW domain containing 1 | ENCODES a protein that exhibits enzyme binding (inferred); Notch binding (inferred); nuclear androgen receptor binding (inferred); INVOLVED IN negative regulation of DNA-templated transcription (ortholog); positive regulation of neurogenesis (ortholog); Schwann cell proliferation (ortholog); PARTICI PATES IN spliceosome pathway; ASSOCIATED WITH Brain Injuries (ortholog); breast cancer (ortholog); breast carcinoma (ortholog); FOUND IN chromatin (ortholog); SMAD protein complex (ortholog) | NW_004936488 | 6494556 | 6531297 | Squirrel | 88 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 626123545 | Snw1 | SNW domain containing 1 | ENCODES a protein that exhibits enzyme binding (ortholog); Notch binding (ortholog); nuclear androgen receptor binding (ortholog); INVOLVED IN cellular response to retinoic acid (ortholog); host-mediated activation of viral transcription (ortholog); intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator (ortholog); PARTICIPATES IN spliceosome pathway; ASSOCIATED WITH Brain Injuries (ortholog); breast cancer (ortholog); breast carcinoma (ortholog); FOUND IN catalytic step 2 spliceosome (ortholog); chromatin (ortholog); cyclin/CDK positive transcription elongation factor complex (ortholog) | | | | Black Rat | 88 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 14193895 | SNW1 | SNW domain containing 1 | ENCODES a protein that exhibits enzyme binding (inferred); Notch binding (inferred); nuclear androgen receptor binding (inferred); INVOLVED IN negative regulation of DNA-templated transcription (ortholog); positive regulation of neurogenesis (ortholog); Schwann cell proliferation (ortholog); PARTICI PATES IN spliceosome pathway; ASSOCIATED WITH Brain Injuries (ortholog); breast cancer (ortholog); breast carcinoma (ortholog); FOUND IN chromatin (ortholog); SMAD protein complex (ortholog); INTERACTS WITH deoxynivalenol | | | | Pig | 89 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18924398 | Snw1 | SNW domain containing 1 | ENCODES a protein that exhibits enzyme binding (ortholog); Notch binding (ortholog); nuclear androgen receptor binding (ortholog); INVOLVED IN cellular response to retinoic acid (ortholog); host-mediated activation of viral transcription (ortholog); intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator (ortholog); PARTICIPATES IN spliceosome pathway; ASSOCIATED WITH Brain Injuries (ortholog); breast cancer (ortholog); breast carcinoma (ortholog); FOUND IN catalytic step 2 spliceosome (ortholog); chromatin (ortholog); cyclin/CDK positive transcription elongation factor complex (ortholog) | | | | Naked Mole-Rat | 92 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18788807 | SNW1 | SNW domain containing 1 | ENCODES a protein that exhibits enzyme binding (inferred); Notch binding (inferred); nuclear androgen receptor binding (inferred); INVOLVED IN negative regulation of DNA-templated transcription (ortholog); positive regulation of neurogenesis (ortholog); Schwann cell proliferation (ortholog); PARTICI PATES IN spliceosome pathway; ASSOCIATED WITH Brain Injuries (ortholog); breast cancer (ortholog); breast carcinoma (ortholog); FOUND IN chromatin (ortholog); SMAD protein complex (ortholog) | | | | Green Monkey | 88 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 155231858 | snw1 | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 155232273 | snw1.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 155234878 | snw1.S | | | | | | African Clawed Frog | | symbol | gene, null |
| 1594499 | Snw1-ps1 | SNW domain containing 1, pseudogene 1 | | 2 | 58467635 | 58469214 | Rat | | symbol , old_gene_name , PhenoGen | gene, pseudo, MODEL [RefSeq] |
| 2324771 | Snw1-ps2 | SNW domain containing 1, pseudogene 2 | | 7 | 82030046 | 82032987 | Rat | | symbol , PhenoGen | gene, pseudo, MODEL [RefSeq] |
| 1590533 | Snw1-ps3 | SNW domain containing 1, pseudogene 3 | | 11 | 93247192 | 93250006 | Rat | | symbol , old_gene_name , PhenoGen | gene, pseudo, INFERRED [RefSeq] |
| 6493141 | Snw1-ps5 | SNW domain containing 1, pseudogene 5 | | 18 | 75750878 | 75752749 | Rat | | symbol , old_gene_name , PhenoGen | gene, pseudo, MODEL [RefSeq] |
| 41213711 | Snw1-ps6 | SNW domain containing 1, pseudogene 6 | | X | 11271244 | 11271882 | Rat | | symbol , PhenoGen | gene, pseudo, MODEL [RefSeq] |
| 16562139 | AC044860.3 | SNW domain containing 1 (SNW1) pseudogene | | | | | Human | | name | gene, unprocessed_pseudogene |
| 16567719 | AC068831.4 | SNW domain containing 1 (SNW1) pseudogene | | | | | Human | | name | gene, unprocessed_pseudogene |
| 16556214 | AC104837.1 | SKI-interacting protein (SNW1) pseudogene | | 1 | 78749072 | 78750856 | Human | | name | gene, pseudo, INFERRED [RefSeq] |
| 25672668 | Gm54546 | predicted gene, 54546 | | | | | Mouse | | old_gene_name | gene, unprocessed_pseudogene |
