| 1307458 | Smpdl3b | sphingomyelin phosphodiesterase, acid-like 3B | ENCODES a protein that exhibits phosphoric diester hydrolase activity (ortholog); zinc ion binding (ortholog); INVOLVED IN membrane lipid catabolic process (ortholog); negative regulation of inflammatory response (ortholog); negative regulation of toll-like receptor signaling pathway (ortholog); FOU ND IN plasma membrane (ortholog); INTERACTS WITH (+)-schisandrin B; 2,3,7,8-tetrachlorodibenzodioxine; 2,4,6-trinitrotoluene | 5 | 150228607 | 150250688 | Rat | 123 | symbol , PhenoGen | gene, protein-coding, PROVISIONAL [RefSeq] |
| 1316663 | SMPDL3B | sphingomyelin phosphodiesterase acid like 3B | Enables phosphoric diester hydrolase activity. Predicted to be involved in membrane lipid catabolic process; negative regulation of inflammatory response; and negative regulation of toll-like receptor signaling pathway. Located in extracellular exosome. [provided by Alliance of Genome Resources, Jul 2025] | 1 | 27935000 | 27959152 | Human | 124 | symbol , COSMIC , Human Proteome Map | gene, protein-coding, VALIDATED [RefSeq] |
| 1316664 | Smpdl3b | sphingomyelin phosphodiesterase, acid-like 3B | Enables phosphoric diester hydrolase activity and zinc ion binding activity. Involved in membrane lipid catabolic process; negative regulation of inflammatory response; and negative regulation of toll-like receptor signaling pathway. Located in plasma membrane. Orthologous to human SMPDL3B -weight:700;'>SMPDL3B (sphingomyelin phosphodiesterase acid like 3B). [provided by Alliance of Genome Resources, Jul 2025] | 4 | 132460277 | 132484558 | Mouse | 126 | symbol , PhenoGen , description | gene, protein-coding, PROVISIONAL [RefSeq] |
| 9018738 | Smpdl3b | sphingomyelin phosphodiesterase acid like 3B | ENCODES a protein that exhibits phosphoric diester hydrolase activity (ortholog); zinc ion binding (ortholog); INVOLVED IN membrane lipid catabolic process (ortholog); negative regulation of inflammatory response (ortholog); negative regulation of toll-like receptor signaling pathway (ortholog); FOU ND IN plasma membrane (ortholog) | NW_004955452 | 7114746 | 7138924 | Chinchilla | 10 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 11967579 | SMPDL3B | sphingomyelin phosphodiesterase acid like 3B | ENCODES a protein that exhibits hydrolase activity (inferred); hydrolase activity, acting on glycosyl bonds (inferred); metal ion binding (inferred); INVOLVED IN immune system process (inferred); inflammatory response (inferred); innate immune response (inferred); FOUND IN extracellular region (infe rred); extracellular space (inferred); membrane (inferred) | 1 | 27194502 | 27219454 | Bonobo | 28 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12241627 | SMPDL3B | sphingomyelin phosphodiesterase acid like 3B | ENCODES a protein that exhibits hydrolase activity (inferred); hydrolase activity, acting on glycosyl bonds (inferred); metal ion binding (inferred); INVOLVED IN immune system process (inferred); inflammatory response (inferred); innate immune response (inferred); FOUND IN extracellular region (infe rred); extracellular space (inferred); membrane (inferred) | 2 | 72427085 | 72450547 | Dog | 28 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12678426 | Smpdl3b | sphingomyelin phosphodiesterase acid like 3B | ENCODES a protein that exhibits hydrolase activity (inferred); hydrolase activity, acting on glycosyl bonds (inferred); metal ion binding (inferred); INVOLVED IN immune system process (inferred); inflammatory response (inferred); innate immune response (inferred); FOUND IN extracellular region (infe rred); extracellular space (inferred); plasma membrane (inferred) | NW_004936474 | 12158628 | 12179993 | Squirrel | 27 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 155236279 | smpdl3b | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 18906665 | Smpdl3b | sphingomyelin phosphodiesterase acid like 3B | ENCODES a protein that exhibits hydrolase activity (inferred); hydrolase activity, acting on glycosyl bonds (inferred); metal ion binding (inferred); INVOLVED IN immune system process (inferred); inflammatory response (inferred); innate immune response (inferred); FOUND IN extracellular region (infe rred); extracellular space (inferred); plasma membrane (inferred) | | | | Naked Mole-Rat | 27 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18617716 | SMPDL3B | sphingomyelin phosphodiesterase acid like 3B | ENCODES a protein that exhibits phosphoric diester hydrolase activity (ortholog); zinc ion binding (ortholog); INVOLVED IN membrane lipid catabolic process (ortholog); negative regulation of inflammatory response (ortholog); negative regulation of toll-like receptor signaling pathway (ortholog); FOU ND IN plasma membrane (ortholog) | | | | Green Monkey | 10 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 625938209 | Smpdl3b | sphingomyelin phosphodiesterase acid like 3B | ENCODES a protein that exhibits phosphoric diester hydrolase activity (ortholog); zinc ion binding (ortholog); INVOLVED IN membrane lipid catabolic process (ortholog); negative regulation of inflammatory response (ortholog); negative regulation of toll-like receptor signaling pathway (ortholog); FOU ND IN plasma membrane (ortholog) | | | | Black Rat | 10 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 14162956 | SMPDL3B | sphingomyelin phosphodiesterase acid like 3B | ENCODES a protein that exhibits hydrolase activity (inferred); hydrolase activity, acting on glycosyl bonds (inferred); metal ion binding (inferred); INVOLVED IN immune system process (inferred); inflammatory response (inferred); innate immune response (inferred); FOUND IN extracellular region (infe rred); extracellular space (inferred); plasma membrane (inferred); INTERACTS WITH deoxynivalenol; graphene oxide | | | | Pig | 27 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 155236280 | smpdl3b.S | | | | | | African Clawed Frog | | symbol | gene, null |
| 12121843 | XKR8 | XK related 8 | ENCODES a protein that exhibits phospholipid scramblase activity (inferred); INVOLVED IN phosphatidylserine exposure on apoptotic cell surface (ortholog); tolerance induction to self antigen (ortholog); FOUND IN membrane (inferred); plasma membrane (inferred) | 2 | 72419950 | 72426315 | Dog | 20 | ensembl_gene_symbol | gene, protein-coding, MODEL [RefSeq] |