| 1320039 | SMG6 | SMG6 nonsense mediated mRNA decay factor | This gene encodes a component of the telomerase ribonucleoprotein complex responsible for the replication and maintenance of chromosome ends. The encoded protein also plays a role in the nonsense-mediated mRNA decay (NMD) pathway, providing the endonuclease activity near the premature translation te rmination codon that is needed to initiate NMD. Alternatively spliced transcript variants encoding distinct protein isoforms have been described. [provided by RefSeq, Feb 2014] | 17 | 2059839 | 2303785 | Human | 113 | symbol , old_gene_name , COSMIC , name , Human Proteome Map | gene, protein-coding, REVIEWED [RefSeq] |
| 1595918 | Smg6 | SMG6 nonsense mediated mRNA decay factor | ENCODES a protein that exhibits DNA polymerase binding (ortholog); ribonucleoprotein complex binding (ortholog); RNA binding (ortholog); INVOLVED IN negative regulation of telomere capping (ortholog); nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (ortholog); regulation of telom ere maintenance (ortholog); PARTICIPATES IN mRNA decay pathway; ASSOCIATED WITH corpus callosum agenesis-abnormal genitalia syndrome (ortholog); FOUND IN cytoplasm (ortholog); cytosol (ortholog); exon-exon junction complex (ortholog); INTERACTS WITH 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine; 6-propyl-2-thiouracil | 10 | 60284628 | 60512738 | Rat | 119 | symbol , PhenoGen , name | gene, protein-coding, PROVISIONAL [RefSeq] |
| 1616658 | Smg6 | SMG6 nonsense mediated mRNA decay factor | Predicted to enable several functions, including DNA polymerase binding activity; telomerase RNA binding activity; and telomeric DNA binding activity. Predicted to be involved in negative regulation of telomere capping and nuclear-transcribed mRNA catabolic process, nonsense-mediated decay. Predicte d to be located in cytosol and nucleolus. Predicted to be part of exon-exon junction complex and telomerase holoenzyme complex. Is expressed in 1-cell stage embryo; 4-cell stage embryo; compacted morula; and cortical plate. Orthologous to human SMG6 (SMG6 nonsense mediated mRNA decay factor). [provided by Alliance of Genome Resources, Apr 2025] | 11 | 74816665 | 75055274 | Mouse | 151 | symbol , old_gene_name , PhenoGen , name , description | gene, protein-coding, VALIDATED [RefSeq] |
| 8819417 | Smg6 | SMG6 nonsense mediated mRNA decay factor | ENCODES a protein that exhibits DNA polymerase binding (ortholog); ribonucleoprotein complex binding (ortholog); RNA binding (ortholog); INVOLVED IN negative regulation of telomere capping (ortholog); nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (ortholog); regulation of telom ere maintenance (ortholog); ASSOCIATED WITH corpus callosum agenesis-abnormal genitalia syndrome (ortholog); FOUND IN cytoplasm (ortholog); cytosol (ortholog); exon-exon junction complex (ortholog) | NW_004955481 | 940041 | 1177998 | Chinchilla | 23 | symbol , old_gene_name , name | gene, protein-coding, MODEL [RefSeq] |
| 11919843 | SMG6 | SMG6 nonsense mediated mRNA decay factor | ENCODES a protein that exhibits DNA polymerase binding (inferred); endonuclease activity (inferred); hydrolase activity (inferred); INVOLVED IN negative regulation of telomere capping (inferred); nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (inferred); regulation of telomere m aintenance (inferred); ASSOCIATED WITH corpus callosum agenesis-abnormal genitalia syndrome (ortholog); FOUND IN chromosome, telomeric region (inferred); cytoplasm (inferred); cytosol (inferred) | 17 | 2050825 | 2294892 | Bonobo | 41 | symbol , old_gene_name , name | gene, protein-coding, MODEL [RefSeq] |
| 12121254 | SMG6 | SMG6 nonsense mediated mRNA decay factor | ENCODES a protein that exhibits DNA polymerase binding (inferred); endonuclease activity (inferred); hydrolase activity (inferred); INVOLVED IN negative regulation of telomere capping (inferred); nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (inferred); regulation of telomere m aintenance (inferred); ASSOCIATED WITH corpus callosum agenesis-abnormal genitalia syndrome (ortholog); FOUND IN chromosome, telomeric region (inferred); cytoplasm (inferred); cytosol (inferred) | 9 | 46162991 | 46405856 | Dog | 42 | symbol , old_gene_name , name | gene, protein-coding, MODEL [RefSeq] |
| 12693014 | Smg6 | SMG6 nonsense mediated mRNA decay factor | ENCODES a protein that exhibits DNA polymerase binding (inferred); endonuclease activity (inferred); hydrolase activity (inferred); INVOLVED IN negative regulation of telomere capping (inferred); nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (inferred); regulation of telomere m aintenance (inferred); ASSOCIATED WITH corpus callosum agenesis-abnormal genitalia syndrome (ortholog); FOUND IN chromosome, telomeric region (inferred); cytoplasm (inferred); cytosol (inferred) | NW_004936538 | 8126307 | 8361920 | Squirrel | 41 | symbol , old_gene_name , name | gene, protein-coding, MODEL [RefSeq] |
| 288057403 | smg6 | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 18590783 | SMG6 | SMG6 nonsense mediated mRNA decay factor | ENCODES a protein that exhibits DNA polymerase binding (inferred); endonuclease activity (inferred); hydrolase activity (inferred); INVOLVED IN negative regulation of telomere capping (inferred); nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (inferred); regulation of telomere m aintenance (inferred); ASSOCIATED WITH corpus callosum agenesis-abnormal genitalia syndrome (ortholog); FOUND IN chromosome, telomeric region (inferred); cytoplasm (inferred); cytosol (inferred) | | | | Green Monkey | 41 | symbol , name | gene, protein-coding, MODEL [RefSeq] |
| 18912774 | Smg6 | SMG6 nonsense mediated mRNA decay factor | ENCODES a protein that exhibits DNA polymerase binding (ortholog); ribonucleoprotein complex binding (ortholog); RNA binding (ortholog); INVOLVED IN negative regulation of telomere capping (ortholog); regulation of telomere maintenance (ortholog); ASSOCIATED WITH corpus callosum agenesis-abnormal ge nitalia syndrome (ortholog); FOUND IN exon-exon junction complex (ortholog) | | | | Naked Mole-Rat | 36 | symbol , name | gene, protein-coding, MODEL [RefSeq] |
| 626083274 | Smg6 | SMG6 nonsense mediated mRNA decay factor | ENCODES a protein that exhibits DNA polymerase binding (ortholog); ribonucleoprotein complex binding (ortholog); RNA binding (ortholog); INVOLVED IN negative regulation of telomere capping (ortholog); nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (ortholog); regulation of telom ere maintenance (ortholog); ASSOCIATED WITH corpus callosum agenesis-abnormal genitalia syndrome (ortholog); FOUND IN cytoplasm (ortholog); cytosol (ortholog); exon-exon junction complex (ortholog) | | | | Black Rat | 23 | symbol , name | gene, protein-coding, MODEL [RefSeq] |
| 14387469 | Smg6 | | | | | | Fly | | symbol | gene, null |
| 13868038 | SMG6 | SMG6 nonsense mediated mRNA decay factor | ENCODES a protein that exhibits DNA polymerase binding (inferred); endonuclease activity (inferred); hydrolase activity (inferred); INVOLVED IN negative regulation of telomere capping (inferred); nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (inferred); regulation of telomere m aintenance (inferred); ASSOCIATED WITH corpus callosum agenesis-abnormal genitalia syndrome (ortholog); FOUND IN chromosome, telomeric region (inferred); cytoplasm (inferred); cytosol (inferred) | | | | Pig | 43 | symbol , name | gene, protein-coding, MODEL [RefSeq] |
| 287814254 | smg6.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 597538576 | SMG6-AS1 | SMG6 antisense RNA 1 | | 17 | 2089738 | 2102303 | Human | | symbol , GTEx , COSMIC , name , Human Proteome Map | gene, ncrna, VALIDATED [RefSeq] |
| 1349752 | SMG6-IT1 | SMG6 intronic transcript 1 | | | | | Human | | symbol , COSMIC , name , Human Proteome Map | gene, ncrna |
| 16556654 | AC090617.2 | novel transcript, antisense to SMG6 | | | | | Human | | name | gene, lncrna |
| 16563627 | AC090617.4 | novel transcript, antisense to SMG6 | | | | | Human | | name | gene, lncrna |
| 16553082 | AL450226.1 | novel transcript, antisense to SMG6 | | 17 | 2232678 | 2233610 | Human | | name | gene, ncrna, VALIDATED [RefSeq] |
| 16556538 | AC090617.1 | novel transcript, sense intronic to SMG6 | | | | | Human | | name | gene, lncrna |
