| 1320184 | Smg5 | SMG5 nonsense mediated mRNA decay factor | Predicted to enable enzyme binding activity; telomerase RNA binding activity; and telomeric DNA binding activity. Predicted to be involved in nuclear-transcribed mRNA catabolic process, nonsense-mediated decay; regulation of dephosphorylation; and regulation of telomere maintenance. Predicted to be located in cytoplasm and nucleus. Predicted to be part of telomerase holoenzyme complex. Orthologous to human SMG5 (SMG5 nonsense mediated mRNA decay factor). [provided by Alliance of Genome Resources, Apr 2025] | 3 | 88242050 | 88269645 | Mouse | 93 | symbol , old_gene_name , PhenoGen , name , description | gene, protein-coding, VALIDATED [RefSeq] |
| 1584731 | Smg5 | SMG5 nonsense mediated mRNA decay factor | ENCODES a protein that exhibits histone deacetylase binding (ortholog); protein phosphatase 2A binding (ortholog); telomerase RNA binding (ortholog); INVOLVED IN regulation of dephosphorylation (ortholog); regulation of telomere maintenance (ortholog); PARTICIPATES IN mRNA decay pathway; FOUND IN cy toplasm (ortholog); cytoplasmic ribonucleoprotein granule (ortholog); nucleus (ortholog); INTERACTS WITH aflatoxin B1; bisphenol A; gentamycin | 2 | 176102812 | 176129925 | Rat | 80 | symbol , old_gene_name , PhenoGen , name | gene, protein-coding, VALIDATED [RefSeq] |
| 1603683 | SMG5 | SMG5 nonsense mediated mRNA decay factor | SMG5 is involved in nonsense-mediated mRNA decay (Ohnishi et al., 2003 [PubMed 14636577]).[supplied by OMIM, Mar 2008] | 1 | 156249224 | 156291516 | Human | 77 | symbol , old_gene_name , COSMIC , name , description , Human Proteome Map | gene, protein-coding, VALIDATED [RefSeq] |
| 9023126 | Smg5 | SMG5 nonsense mediated mRNA decay factor | ENCODES a protein that exhibits histone deacetylase binding (ortholog); protein phosphatase 2A binding (ortholog); telomerase RNA binding (ortholog); INVOLVED IN regulation of dephosphorylation (ortholog); regulation of telomere maintenance (ortholog); FOUND IN cytoplasm (ortholog); cytoplasmic ribo nucleoprotein granule (ortholog); nucleus (ortholog) | NW_004955545 | 2386877 | 2418418 | Chinchilla | 15 | symbol , old_gene_name , name | gene, protein-coding, MODEL [RefSeq] |
| 11871366 | SMG5 | SMG5 nonsense mediated mRNA decay factor | ENCODES a protein that exhibits histone deacetylase binding (inferred); protein phosphatase 2A binding (inferred); telomerase RNA binding (inferred); INVOLVED IN nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (inferred); regulation of dephosphorylation (inferred); regulation of telomere maintenance (inferred); FOUND IN cytoplasm (inferred); cytoplasmic ribonucleoprotein granule (inferred); nucleus (inferred) | 1 | 131592368 | 131634443 | Bonobo | 23 | symbol , old_gene_name , name | gene, protein-coding, MODEL [RefSeq] |
| 12425734 | SMG5 | SMG5 nonsense mediated mRNA decay factor | ENCODES a protein that exhibits histone deacetylase binding (inferred); protein phosphatase 2A binding (inferred); telomerase RNA binding (inferred); INVOLVED IN nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (inferred); regulation of dephosphorylation (inferred); regulation of telomere maintenance (inferred); FOUND IN cytoplasm (inferred); cytoplasmic ribonucleoprotein granule (inferred); nucleus (inferred) | 7 | 41598111 | 41624575 | Dog | 23 | symbol , old_gene_name , name | gene, protein-coding, MODEL [RefSeq] |
| 12569827 | Smg5 | SMG5 nonsense mediated mRNA decay factor | ENCODES a protein that exhibits histone deacetylase binding (inferred); protein phosphatase 2A binding (inferred); telomerase RNA binding (inferred); INVOLVED IN nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (inferred); regulation of dephosphorylation (inferred); regulation of telomere maintenance (inferred); FOUND IN cytoplasm (inferred); cytoplasmic ribonucleoprotein granule (inferred); nucleus (inferred) | NW_004936580 | 5487522 | 5516448 | Squirrel | 23 | symbol , old_gene_name , name | gene, protein-coding, MODEL [RefSeq] |
| 626013277 | Smg5 | SMG5 nonsense mediated mRNA decay factor | ENCODES a protein that exhibits histone deacetylase binding (ortholog); protein phosphatase 2A binding (ortholog); telomerase RNA binding (ortholog); INVOLVED IN regulation of dephosphorylation (ortholog); regulation of telomere maintenance (ortholog); FOUND IN cytoplasm (ortholog); cytoplasmic ribo nucleoprotein granule (ortholog); nucleus (ortholog) | | | | Black Rat | 15 | symbol , old_gene_name , name | gene, protein-coding, MODEL [RefSeq] |
| 287633165 | smg5 | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 18415267 | SMG5 | SMG5 nonsense mediated mRNA decay factor | ENCODES a protein that exhibits histone deacetylase binding (inferred); protein phosphatase 2A binding (inferred); telomerase RNA binding (inferred); INVOLVED IN nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (inferred); regulation of dephosphorylation (inferred); regulation of telomere maintenance (inferred); FOUND IN cytoplasm (inferred); cytoplasmic ribonucleoprotein granule (inferred); nucleus (inferred) | | | | Green Monkey | 23 | symbol , old_gene_name , name | gene, protein-coding, MODEL [RefSeq] |
| 14010843 | SMG5 | SMG5 nonsense mediated mRNA decay factor | ENCODES a protein that exhibits histone deacetylase binding (inferred); protein phosphatase 2A binding (inferred); telomerase RNA binding (inferred); INVOLVED IN nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (inferred); regulation of dephosphorylation (inferred); regulation of telomere maintenance (inferred); FOUND IN cytoplasm (inferred); cytoplasmic ribonucleoprotein granule (inferred); nucleus (inferred) | | | | Pig | 23 | symbol , old_gene_name , name | gene, protein-coding, MODEL [RefSeq] |
| 14388487 | Smg5 | | | | | | Fly | | symbol | gene, null |
| 18916209 | Smg5 | SMG5 nonsense mediated mRNA decay factor | ENCODES a protein that exhibits histone deacetylase binding (ortholog); protein phosphatase 2A binding (ortholog); ubiquitin protein ligase binding (ortholog); INVOLVED IN regulation of dephosphorylation (ortholog); regulation of telomere maintenance (ortholog); FOUND IN cytoplasmic ribonucleoprotei n granule (ortholog) | | | | Naked Mole-Rat | 19 | symbol , old_gene_name , name | gene, protein-coding, MODEL [RefSeq] |
| 285442687 | smg5.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 405863892 | smg5.S | | | | | | African Clawed Frog | | symbol | gene, null |
| 626180694 | smg5.S | | | | | | African Clawed Frog | | symbol | gene, null |
| 405858477 | smg5.S | | | | | | African Clawed Frog | | symbol | gene, null |
| 405860001 | smg5.S | | | | | | African Clawed Frog | | symbol | gene, null |
| 405858044 | smg5.S | | | | | | African Clawed Frog | | symbol | gene, null |
| 12622442 | LOC101976097 | protein SMG5-like | | NW_004936470 | 35252429 | 35366536 | Squirrel | | name | gene, protein-coding, MODEL [RefSeq] |
| 8941172 | LOC102025684 | protein SMG5-like | | NW_004955417 | 17042988 | 17151009 | Chinchilla | | name | gene, protein-coding, MODEL [RefSeq] |
| 625934551 | LOC116911200 | protein SMG5-like | | | | | Black Rat | | name | gene, protein-coding, MODEL [RefSeq] |
| 14051342 | LOC100521034 | protein SMG5 pseudogene | | | | | Pig | | name | gene, pseudo, MODEL [RefSeq] |
| 18908819 | LOC101715581 | protein SMG5 pseudogene | | | | | Naked Mole-Rat | | name | gene, pseudo, MODEL [RefSeq] |
| 1309489 | Smg5l1 | Smg5 nonsense mediated mRNA decay factor like 1 | INVOLVED IN nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (inferred); PARTICIPATES IN mRNA decay pathway; FOUND IN cytoplasm (inferred); nucleus (inferred); INTERACTS WITH bisphenol A | 7 | 77802126 | 77936486 | Rat | 6 | symbol , PhenoGen , name | gene, protein-coding, VALIDATED [RefSeq] |
| 16560581 | AC023245.2 | Smg-5 homolog, nonsense mediated mRNA decay factor (C. elegans) (SMG5) pseudogene | | 8 | 109777938 | 109782261 | Human | | old_gene_name , name | gene, pseudo, INFERRED [RefSeq] |
| 1321852 | SMG7 | SMG7 nonsense mediated mRNA decay factor | This gene encodes a protein that is essential for nonsense-mediated mRNA decay (NMD); a process whereby transcripts with premature termination codons are targeted for rapid degradation by a mRNA decay complex. The mRNA decay complex consists, in part, of this protein along with proteins SMG5 'font-weight:700;'>SMG5 and UPF1. The N-terminal domain of this protein is thought to mediate its association with SMG5 or UPF1 while the C-terminal domain interacts with the mRNA decay complex. This protein may therefore couple changes in UPF1 phosphorylation state to the degradation of NMD-candidate transcripts. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Aug 2011] | 1 | 183472499 | 183554191 | Human | 79 | description | gene, protein-coding, REVIEWED [RefSeq] |