| 1308193 | Slc9a8 | solute carrier family 9 member A8 | ENCODES a protein that exhibits sodium:proton antiporter activity; potassium:proton antiporter activity (ortholog); INVOLVED IN proton transmembrane transport; regulation of intracellular pH; sodium ion transmembrane transport; ASSOCIATED WITH dementia (ortholog); FOUND IN apical plasma membrane; ac rosomal vesicle (ortholog); Golgi apparatus (ortholog); INTERACTS WITH 2,3,7,8-Tetrachlorodibenzofuran; bisphenol A; C60 fullerene | 3 | 176559658 | 176617510 | Rat | 116 | symbol , PhenoGen | gene, protein-coding, VALIDATED [RefSeq] |
| 1317829 | SLC9A8 | solute carrier family 9 member A8 | Sodium-hydrogen exchangers (NHEs), such as SLC9A8, are integral transmembrane proteins that exchange extracellular Na+ for intracellular H+. NHEs have multiple functions, including intracellular pH homeostasis, cell volume regulation, and electroneutral NaCl abs orption in epithelia (Xu et al., 2008 [PubMed 18209477]).[supplied by OMIM, Apr 2009] | 20 | 49812828 | 49892242 | Human | 108 | symbol , COSMIC , description , Human Proteome Map | gene, protein-coding, VALIDATED [RefSeq] |
| 1317830 | Slc9a8 | solute carrier family 9 (sodium/hydrogen exchanger), member 8 | This gene encodes a member of the Na+/H+ exchanger (NHE) family of integral membrane transporter proteins. The encoded protein is expressed on the apical membrane of the intestinal epithelial cells and plays an important role in mucosal protection. Loss of the encoded protein in mice results in a de crease in the number of goblet and mucin-positive cells, disorganization of the mucin layer, and a decrease in mucosal pH in the colon. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jan 2015] | 2 | 167261678 | 167318920 | Mouse | 147 | symbol , PhenoGen | gene, protein-coding, REVIEWED [RefSeq] |
| 8915912 | Slc9a8 | solute carrier family 9 member A8 | ENCODES a protein that exhibits potassium:proton antiporter activity (ortholog); sodium:proton antiporter activity (ortholog); INVOLVED IN acrosome assembly (ortholog); potassium ion transport (ortholog); proton transmembrane transport (ortholog); ASSOCIATED WITH dementia (ortholog); FOUND IN acroso mal vesicle (ortholog); apical plasma membrane (ortholog); Golgi apparatus (ortholog) | NW_004955445 | 8308847 | 8384146 | Chinchilla | 28 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 11808832 | SLC9A8 | solute carrier family 9 member A8 | ENCODES a protein that exhibits antiporter activity (inferred); potassium:proton antiporter activity (inferred); sodium:proton antiporter activity (inferred); INVOLVED IN potassium ion transport (ortholog); regulation of intracellular pH (ortholog); sodium ion transport (ortholog); ASSOCIATED WITH d ementia (ortholog); FOUND IN Golgi apparatus (ortholog) | 20 | 46155299 | 46234418 | Bonobo | 34 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12423493 | SLC9A8 | solute carrier family 9 member A8 | ENCODES a protein that exhibits antiporter activity (inferred); potassium:proton antiporter activity (inferred); sodium:proton antiporter activity (inferred); INVOLVED IN potassium ion transport (ortholog); regulation of intracellular pH (ortholog); sodium ion transport (ortholog); ASSOCIATED WITH d ementia (ortholog); FOUND IN Golgi apparatus (ortholog) | 24 | 36364053 | 36434216 | Dog | 35 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12737696 | Slc9a8 | solute carrier family 9 member A8 | ENCODES a protein that exhibits antiporter activity (inferred); potassium:proton antiporter activity (inferred); sodium:proton antiporter activity (inferred); INVOLVED IN potassium ion transport (ortholog); regulation of intracellular pH (ortholog); sodium ion transport (ortholog); ASSOCIATED WITH d ementia (ortholog); FOUND IN Golgi apparatus (ortholog) | NW_004936514 | 4518798 | 4595003 | Squirrel | 34 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18781082 | SLC9A8 | solute carrier family 9 member A8 | ENCODES a protein that exhibits antiporter activity (inferred); potassium:proton antiporter activity (inferred); sodium:proton antiporter activity (inferred); INVOLVED IN potassium ion transport (ortholog); regulation of intracellular pH (ortholog); sodium ion transport (ortholog); ASSOCIATED WITH d ementia (ortholog); FOUND IN Golgi apparatus (ortholog) | | | | Green Monkey | 33 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18927924 | Slc9a8 | solute carrier family 9 member A8 | ENCODES a protein that exhibits antiporter activity (inferred); potassium:proton antiporter activity (inferred); sodium:proton antiporter activity (inferred); INVOLVED IN acrosome assembly (ortholog); potassium ion transport (ortholog); regulation of Golgi lumen acidification (ortholog); ASSOCIATED WITH dementia (ortholog); FOUND IN acrosomal vesicle (ortholog); apical plasma membrane (ortholog); Golgi apparatus (ortholog) | | | | Naked Mole-Rat | 32 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 626156478 | Slc9a8 | solute carrier family 9 member A8 | ENCODES a protein that exhibits potassium:proton antiporter activity (ortholog); sodium:proton antiporter activity (ortholog); INVOLVED IN acrosome assembly (ortholog); potassium ion transport (ortholog); proton transmembrane transport (ortholog); ASSOCIATED WITH dementia (ortholog); FOUND IN acroso mal vesicle (ortholog); apical plasma membrane (ortholog); Golgi apparatus (ortholog) | | | | Black Rat | 28 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 155234778 | slc9a8 | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 14112506 | SLC9A8 | solute carrier family 9 member A8 | ENCODES a protein that exhibits antiporter activity (inferred); potassium:proton antiporter activity (inferred); sodium:proton antiporter activity (inferred); INVOLVED IN potassium ion transport (ortholog); regulation of intracellular pH (ortholog); sodium ion transport (ortholog); ASSOCIATED WITH d ementia (ortholog); FOUND IN Golgi apparatus (ortholog) | | | | Pig | 35 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 155245534 | slc9a8.S | | | | | | African Clawed Frog | | symbol | gene, null |