| 62066 | Slc37a4 | solute carrier family 37 member 4 | ENCODES a protein that exhibits glucose-6-phosphate transmembrane transporter activity; glucose 6-phosphate:phosphate antiporter activity (ortholog); INVOLVED IN glucose-6-phosphate transport; response to glucose; response to nutrient; PARTICIPATES IN electron transport chain pathway; fructose-1,6-b isphosphatase deficiency pathway; gluconeogenesis pathway; ASSOCIATED WITH Experimental Diabetes Mellitus; congenital disorder of glycosylation (ortholog); congenital disorder of glycosylation type IIw (ortholog); FOUND IN endoplasmic reticulum membrane (ortholog); INTERACTS WITH (+)-schisandrin B; 1,2,4-trimethylbenzene; 17beta-estradiol | 8 | 53619952 | 53626110 | Rat | 228 | symbol , old_gene_name , PhenoGen | gene, protein-coding, VALIDATED [RefSeq] |
| 62358 | Slc37a4 | solute carrier family 37 (glucose-6-phosphate transporter), member 4 | Enables glucose 6-phosphate:phosphate antiporter activity. Involved in gluconeogenesis. Acts upstream of or within several processes, including cholesterol homeostasis; glucose-6-phosphate transport; and hemopoiesis. Is active in endoplasmic reticulum membrane. Is expressed in several structures, in cluding alimentary system; central nervous system; genitourinary system; liver; and spleen. Used to study glycogen storage disease Ia. Human ortholog(s) of this gene implicated in congenital disorder of glycosylation type IIw; glycogen storage disease Ib; and glycogen storage disease Ic. Orthologous to human SLC37A4 (solute carrier family 37 member 4). [provided by Alliance of Genome Resources, Apr 2025] | 9 | 44308243 | 44314263 | Mouse | 257 | symbol , old_gene_name , PhenoGen , description | gene, protein-coding, VALIDATED [RefSeq] |
| 1351082 | SLC37A4 | solute carrier family 37 member 4 | This gene regulates glucose-6-phosphate transport from the cytoplasm to the lumen of the endoplasmic reticulum, in order to maintain glucose homeostasis. It also plays a role in ATP-mediated calcium sequestration in the lumen of the endoplasmic reticulum. Mutations in this gene have been associated with various forms of glycogen storage disease. Alternative splicing in this gene results in multiple transcript variants.[provided by RefSeq, Aug 2009] | 11 | 119024112 | 119030877 | Human | 547 | symbol , old_gene_name , COSMIC , Human Proteome Map | gene, protein-coding, REVIEWED [RefSeq] |
| 8785323 | Slc37a4 | solute carrier family 37 member 4 | ENCODES a protein that exhibits glucose 6-phosphate:phosphate antiporter activity (ortholog); glucose-6-phosphate transmembrane transporter activity (ortholog); INVOLVED IN cholesterol homeostasis (ortholog); gluconeogenesis (ortholog); glucose homeostasis (ortholog); PARTICIPATES IN electron transp ort chain pathway; fructose-1,6-bisphosphatase deficiency pathway; gluconeogenesis pathway; ASSOCIATED WITH congenital disorder of glycosylation (ortholog); congenital disorder of glycosylation type IIw (ortholog); Experimental Diabetes Mellitus (ortholog); FOUND IN endoplasmic reticulum membrane (ortholog) | NW_004955412 | 20133652 | 20140134 | Chinchilla | 57 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12033040 | SLC37A4 | solute carrier family 37 member 4 | ENCODES a protein that exhibits glucose-6-phosphate transmembrane transporter activity (ortholog); INVOLVED IN cholesterol homeostasis (ortholog); glucose homeostasis (ortholog); glucose-6-phosphate transport (ortholog); PARTICIPATES IN electron transport chain pathway; fructose-1,6-bisphosphatase d eficiency pathway; gluconeogenesis pathway; ASSOCIATED WITH congenital disorder of glycosylation (ortholog); congenital disorder of glycosylation type IIw (ortholog); Experimental Diabetes Mellitus (ortholog); FOUND IN endomembrane system (inferred); endoplasmic reticulum membrane (inferred); membrane (inferred) | 11 | 113862537 | 113869447 | Bonobo | 60 | symbol , old_gene_name | gene, protein-coding, MODEL [RefSeq] |
| 12316800 | SLC37A4 | solute carrier family 37 member 4 | ENCODES a protein that exhibits glucose-6-phosphate transmembrane transporter activity (ortholog); INVOLVED IN cholesterol homeostasis (ortholog); glucose homeostasis (ortholog); glucose-6-phosphate transport (ortholog); PARTICIPATES IN electron transport chain pathway; fructose-1,6-bisphosphatase d eficiency pathway; gluconeogenesis pathway; ASSOCIATED WITH congenital disorder of glycosylation (ortholog); congenital disorder of glycosylation type IIw (ortholog); Experimental Diabetes Mellitus (ortholog); FOUND IN endoplasmic reticulum membrane (ortholog) | 5 | 14823485 | 14830007 | Dog | 62 | symbol , old_gene_name | gene, protein-coding, VALIDATED [RefSeq] |
| 12703092 | Slc37a4 | solute carrier family 37 member 4 | ENCODES a protein that exhibits glucose-6-phosphate transmembrane transporter activity (ortholog); INVOLVED IN cholesterol homeostasis (ortholog); glucose homeostasis (ortholog); glucose-6-phosphate transport (ortholog); PARTICIPATES IN electron transport chain pathway; fructose-1,6-bisphosphatase d eficiency pathway; gluconeogenesis pathway; ASSOCIATED WITH congenital disorder of glycosylation (ortholog); congenital disorder of glycosylation type IIw (ortholog); Experimental Diabetes Mellitus (ortholog); FOUND IN endomembrane system (inferred); endoplasmic reticulum membrane (inferred); membrane (inferred) | NW_004936542 | 3980538 | 3987039 | Squirrel | 60 | symbol , old_gene_name | gene, protein-coding, MODEL [RefSeq] |
| 18501348 | SLC37A4 | solute carrier family 37 member 4 | ENCODES a protein that exhibits glucose-6-phosphate transmembrane transporter activity (ortholog); INVOLVED IN cholesterol homeostasis (ortholog); glucose homeostasis (ortholog); glucose-6-phosphate transport (ortholog); PARTICIPATES IN electron transport chain pathway; fructose-1,6-bisphosphatase d eficiency pathway; gluconeogenesis pathway; ASSOCIATED WITH congenital disorder of glycosylation (ortholog); congenital disorder of glycosylation type IIw (ortholog); Experimental Diabetes Mellitus (ortholog); FOUND IN endomembrane system (inferred); endoplasmic reticulum membrane (inferred); membrane (inferred) | | | | Green Monkey | 60 | symbol , old_gene_name | gene, protein-coding, MODEL [RefSeq] |
| 13992843 | SLC37A4 | solute carrier family 37 member 4 | ENCODES a protein that exhibits glucose-6-phosphate transmembrane transporter activity (ortholog); INVOLVED IN cholesterol homeostasis (ortholog); glucose homeostasis (ortholog); glucose-6-phosphate transport (ortholog); PARTICIPATES IN electron transport chain pathway; fructose-1,6-bisphosphatase d eficiency pathway; gluconeogenesis pathway; ASSOCIATED WITH congenital disorder of glycosylation (ortholog); congenital disorder of glycosylation type IIw (ortholog); Experimental Diabetes Mellitus (ortholog); FOUND IN endoplasmic reticulum membrane (ortholog); INTERACTS WITH deoxynivalenol | | | | Pig | 63 | symbol , old_gene_name | gene, protein-coding, PROVISIONAL [RefSeq] |
| 284993183 | slc37a4 | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 18911174 | Slc37a4 | solute carrier family 37 member 4 | ENCODES a protein that exhibits glucose-6-phosphate transmembrane transporter activity (ortholog); INVOLVED IN cholesterol homeostasis (ortholog); gluconeogenesis (ortholog); glucose homeostasis (ortholog); PARTICIPATES IN electron transport chain pathway; fructose-1,6-bisphosphatase deficiency path way; gluconeogenesis pathway; ASSOCIATED WITH congenital disorder of glycosylation (ortholog); congenital disorder of glycosylation type IIw (ortholog); Experimental Diabetes Mellitus (ortholog); FOUND IN endoplasmic reticulum membrane (ortholog) | | | | Naked Mole-Rat | 59 | symbol , old_gene_name | gene, protein-coding, MODEL [RefSeq] |
| 626121512 | Slc37a4 | solute carrier family 37 member 4 | ENCODES a protein that exhibits glucose 6-phosphate:phosphate antiporter activity (ortholog); glucose-6-phosphate transmembrane transporter activity (ortholog); INVOLVED IN cholesterol homeostasis (ortholog); gluconeogenesis (ortholog); glucose homeostasis (ortholog); PARTICIPATES IN electron transp ort chain pathway; fructose-1,6-bisphosphatase deficiency pathway; gluconeogenesis pathway; ASSOCIATED WITH congenital disorder of glycosylation (ortholog); congenital disorder of glycosylation type IIw (ortholog); Experimental Diabetes Mellitus (ortholog); FOUND IN endoplasmic reticulum membrane (ortholog) | | | | Black Rat | 56 | symbol , old_gene_name | gene, protein-coding, MODEL [RefSeq] |
| 286932203 | slc37a4.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 405861284 | slc37a4.S | | | | | | African Clawed Frog | | symbol | gene, null |
| 405857536 | slc37a4.S | | | | | | African Clawed Frog | | symbol | gene, null |
| 626175373 | slc37a4.S | | | | | | African Clawed Frog | | symbol | gene, null |
| 405856970 | slc37a4.S | | | | | | African Clawed Frog | | symbol | gene, null |
| 405863060 | slc37a4.S | | | | | | African Clawed Frog | | symbol | gene, null |