| 620623 | Slc26a3 | solute carrier family 26 member 3 | ENCODES a protein that exhibits bicarbonate transmembrane transporter activity (ortholog); chloride transmembrane transporter activity (ortholog); chloride:bicarbonate antiporter activity (ortholog); INVOLVED IN cellular response to cAMP (ortholog); intracellular pH elevation (ortholog); membrane hy perpolarization (ortholog); PARTICIPATES IN cimetidine pharmacodynamics pathway; esomeprazole pharmacodynamics pathway; famotidine pharmacodynamics pathway; ASSOCIATED WITH congenital secretory chloride diarrhea 1 (ortholog); diarrhea (ortholog); genetic disease (ortholog); FOUND IN apical plasma membrane; brush border membrane; membrane (ortholog); INTERACTS WITH 6-propyl-2-thiouracil; all-trans-retinoic acid; allethrin | 6 | 53751415 | 53792300 | Rat | 151 | symbol , PhenoGen | gene, protein-coding, PROVISIONAL [RefSeq] |
| 1346275 | SLC26A3 | solute carrier family 26 member 3 | The protein encoded by this gene is a transmembrane glycoprotein that transports chloride ions across the cell membrane in exchange for bicarbonate ions. It is localized to the mucosa of the lower intestinal tract, particularly to the apical membrane of columnar epithelium and some goblet cells. The protein is essential for intestinal chloride absorption, and mutations in this gene have been associated with congenital chloride diarrhea. [provided by RefSeq, Oct 2008] | 7 | 107765469 | 107803223 | Human | 222 | symbol , COSMIC , Human Proteome Map | gene, protein-coding, REVIEWED [RefSeq] |
| 1550421 | Slc26a3 | solute carrier family 26, member 3 | This gene encodes a member of the solute carrier/sulfate transporter family. The encoded protein is predominantly expressed in the intestine where it is essential for chloride absorption. Disruption of this gene results in chloride-rich diarrhea and compensatory up-regulation of ion-absorbing transp orters. [provided by RefSeq, Dec 2012] | 12 | 31483141 | 31523921 | Mouse | 155 | symbol , PhenoGen | gene, protein-coding, REVIEWED [RefSeq] |
| 8762763 | Slc26a3 | solute carrier family 26 member 3 | ENCODES a protein that exhibits bicarbonate transmembrane transporter activity (ortholog); chloride transmembrane transporter activity (ortholog); chloride:bicarbonate antiporter activity (ortholog); INVOLVED IN cellular response to cAMP (ortholog); intracellular pH elevation (ortholog); membrane hy perpolarization (ortholog); PARTICIPATES IN cimetidine pharmacodynamics pathway; esomeprazole pharmacodynamics pathway; famotidine pharmacodynamics pathway; ASSOCIATED WITH congenital secretory chloride diarrhea 1 (ortholog); diarrhea (ortholog); genetic disease (ortholog); FOUND IN apical plasma membrane (ortholog); brush border membrane (ortholog); membrane (ortholog) | NW_004955410 | 12102356 | 12128620 | Chinchilla | 38 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 11966236 | SLC26A3 | solute carrier family 26 member 3 | ENCODES a protein that exhibits bicarbonate transmembrane transporter activity (inferred); chloride transmembrane transporter activity (inferred); chloride:bicarbonate antiporter activity (inferred); INVOLVED IN bicarbonate transport (inferred); cellular response to cAMP (inferred); chloride transme mbrane transport (inferred); PARTICIPATES IN cimetidine pharmacodynamics pathway; esomeprazole pharmacodynamics pathway; famotidine pharmacodynamics pathway; ASSOCIATED WITH congenital secretory chloride diarrhea 1 (ortholog); diarrhea (ortholog); genetic disease (ortholog); FOUND IN apical plasma membrane (ortholog); brush border membrane (ortholog) | 7 | 99747405 | 99776763 | Bonobo | 44 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12152407 | SLC26A3 | solute carrier family 26 member 3 | ENCODES a protein that exhibits bicarbonate transmembrane transporter activity (inferred); chloride transmembrane transporter activity (inferred); chloride:bicarbonate antiporter activity (inferred); INVOLVED IN bicarbonate transport (inferred); cellular response to cAMP (inferred); intracellular pH elevation (inferred); PARTICIPATES IN cimetidine pharmacodynamics pathway; esomeprazole pharmacodynamics pathway; famotidine pharmacodynamics pathway; ASSOCIATED WITH congenital secretory chloride diarrhea 1 (ortholog); diarrhea (ortholog); genetic disease (ortholog); FOUND IN apical plasma membrane (ortholog); brush border membrane (ortholog) | 18 | 12817177 | 12843502 | Dog | 50 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12691745 | Slc26a3 | solute carrier family 26 member 3 | ENCODES a protein that exhibits bicarbonate transmembrane transporter activity (inferred); chloride transmembrane transporter activity (inferred); chloride:bicarbonate antiporter activity (inferred); INVOLVED IN bicarbonate transport (inferred); cellular response to cAMP (inferred); chloride transme mbrane transport (inferred); PARTICIPATES IN cimetidine pharmacodynamics pathway; esomeprazole pharmacodynamics pathway; famotidine pharmacodynamics pathway; ASSOCIATED WITH congenital secretory chloride diarrhea 1 (ortholog); diarrhea (ortholog); genetic disease (ortholog); FOUND IN apical plasma membrane (ortholog); brush border membrane (ortholog) | NW_004936479 | 16350746 | 16374911 | Squirrel | 44 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 13931656 | SLC26A3 | solute carrier family 26 member 3 | ENCODES a protein that exhibits bicarbonate transmembrane transporter activity (inferred); chloride transmembrane transporter activity (inferred); chloride:bicarbonate antiporter activity (inferred); INVOLVED IN bicarbonate transport (inferred); cellular response to cAMP (inferred); intracellular pH elevation (inferred); PARTICIPATES IN cimetidine pharmacodynamics pathway; esomeprazole pharmacodynamics pathway; famotidine pharmacodynamics pathway; ASSOCIATED WITH congenital secretory chloride diarrhea 1 (ortholog); diarrhea (ortholog); genetic disease (ortholog); FOUND IN apical plasma membrane (ortholog); brush border membrane (ortholog); INTERACTS WITH deoxynivalenol | | | | Pig | 51 | symbol | gene, protein-coding, PROVISIONAL [RefSeq] |
| 625971121 | Slc26a3 | solute carrier family 26 member 3 | ENCODES a protein that exhibits bicarbonate transmembrane transporter activity (ortholog); chloride transmembrane transporter activity (ortholog); chloride:bicarbonate antiporter activity (ortholog); INVOLVED IN cellular response to cAMP (ortholog); intracellular pH elevation (ortholog); membrane hy perpolarization (ortholog); PARTICIPATES IN cimetidine pharmacodynamics pathway; esomeprazole pharmacodynamics pathway; famotidine pharmacodynamics pathway; ASSOCIATED WITH congenital secretory chloride diarrhea 1 (ortholog); diarrhea (ortholog); genetic disease (ortholog); FOUND IN apical plasma membrane (ortholog); brush border membrane (ortholog); membrane (ortholog) | | | | Black Rat | 37 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18916892 | Slc26a3 | solute carrier family 26 member 3 | ENCODES a protein that exhibits bicarbonate transmembrane transporter activity (ortholog); chloride transmembrane transporter activity (ortholog); chloride:bicarbonate antiporter activity (ortholog); INVOLVED IN cellular response to cAMP (ortholog); intracellular pH elevation (ortholog); membrane hy perpolarization (ortholog); PARTICIPATES IN cimetidine pharmacodynamics pathway; esomeprazole pharmacodynamics pathway; famotidine pharmacodynamics pathway; ASSOCIATED WITH congenital secretory chloride diarrhea 1 (ortholog); diarrhea (ortholog); genetic disease (ortholog); FOUND IN apical plasma membrane (ortholog); brush border membrane (ortholog); plasma membrane (ortholog) | | | | Naked Mole-Rat | 42 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18398454 | SLC26A3 | solute carrier family 26 member 3 | ENCODES a protein that exhibits bicarbonate transmembrane transporter activity (inferred); chloride transmembrane transporter activity (inferred); chloride:bicarbonate antiporter activity (inferred); INVOLVED IN bicarbonate transport (inferred); cellular response to cAMP (inferred); chloride transme mbrane transport (inferred); PARTICIPATES IN cimetidine pharmacodynamics pathway; esomeprazole pharmacodynamics pathway; famotidine pharmacodynamics pathway; ASSOCIATED WITH congenital secretory chloride diarrhea 1 (ortholog); diarrhea (ortholog); genetic disease (ortholog); FOUND IN apical plasma membrane (ortholog); brush border membrane (ortholog) | | | | Green Monkey | 44 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 155255482 | slc26a3.2 | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 284036823 | slc26a3.3 | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 596935472 | slc26a3.2.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 596934716 | slc26a3.2.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 596936115 | slc26a3.2.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 596934092 | slc26a3.2.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 155254650 | slc26a3.2.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 155236327 | slc26a3.2.S | | | | | | African Clawed Frog | | symbol | gene, null |
| 288083338 | slc26a3.3.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 284291735 | slc26a3.3.S | | | | | | African Clawed Frog | | symbol | gene, null |
| 736428 | SLC26A4 | solute carrier family 26 member 4 | Mutations in this gene are associated with Pendred syndrome, the most common form of syndromic deafness, an autosomal-recessive disease. It is highly homologous to the SLC26A3 gene; they have similar genomic structures and this gene is located 3' of the SLC26A3 yle='font-weight:700;'>SLC26A3 gene. The encoded protein has homology to sulfate transporters. [provided by RefSeq, Jul 2008] | 7 | 107660828 | 107717809 | Human | 879 | description | gene, protein-coding, REVIEWED [RefSeq] |