| 1343771 | SLC25A19 | solute carrier family 25 member 19 | This gene encodes a mitochondrial protein that is a member of the solute carrier family. Although this protein was initially thought to be the mitochondrial deoxynucleotide carrier involved in the uptake of deoxynucleotides into the matrix of the mitochondria, further studies have demonstrated that this protein instead functions as the mitochondrial thiamine pyrophosphate carrier, which transports thiamine pyrophosphates into mitochondria. Mutations in this gene cause microcephaly, Amish type, a metabolic disease that results in severe congenital microcephaly, severe 2-ketoglutaric aciduria, and death within the first year. Multiple alternatively spliced variants, encoding the same protein, have been identified for this gene. [provided by RefSeq, Jul 2008] | 17 | 75272992 | 75289433 | Human | 207 | symbol , COSMIC , Human Proteome Map | gene, protein-coding, REVIEWED [RefSeq] |
| 1359554 | Slc25a19 | solute carrier family 25 member 19 | ENCODES a protein that exhibits deoxynucleotide transmembrane transporter activity (ortholog); thiamine pyrophosphate transmembrane transporter activity (ortholog); INVOLVED IN deoxynucleotide transport (ortholog); thiamine diphosphate biosynthetic process (ortholog); thiamine pyrophosphate transmem brane transport (ortholog); ASSOCIATED WITH Amish Lethal Microcephaly (ortholog); genetic disease (ortholog); microcephaly (ortholog); FOUND IN mitochondrial inner membrane (ortholog); mitochondrion (ortholog); INTERACTS WITH 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine; 2,4-dinitrotoluene | 10 | 101353426 | 101366551 | Rat | 128 | symbol , PhenoGen | gene, protein-coding, PROVISIONAL [RefSeq] |
| 1551315 | Slc25a19 | solute carrier family 25 (mitochondrial thiamine pyrophosphate carrier), member 19 | Enables thiamine pyrophosphate transmembrane transporter activity. Involved in thiamine diphosphate biosynthetic process. Located in mitochondrion. Is active in mitochondrial inner membrane. Is expressed in central nervous system; embryo; retina inner nuclear layer; retina layer; and retina outer nu clear layer. Human ortholog(s) of this gene implicated in inherited metabolic disorder and microcephaly. Orthologous to human SLC25A19 (solute carrier family 25 member 19). [provided by Alliance of Genome Resources, Jul 2025] | 11 | 115504991 | 115519122 | Mouse | 146 | symbol , PhenoGen , description | gene, protein-coding, VALIDATED [RefSeq] |
| 8725008 | Slc25a19 | solute carrier family 25 member 19 | ENCODES a protein that exhibits deoxynucleotide transmembrane transporter activity (ortholog); thiamine pyrophosphate transmembrane transporter activity (ortholog); INVOLVED IN deoxynucleotide transport (ortholog); thiamine diphosphate biosynthetic process (ortholog); thiamine pyrophosphate transmem brane transport (ortholog); ASSOCIATED WITH Amish Lethal Microcephaly (ortholog); genetic disease (ortholog); microcephaly (ortholog); FOUND IN mitochondrial inner membrane (ortholog); mitochondrion (ortholog) | NW_004955553 | 2134715 | 2160777 | Chinchilla | 16 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 11833956 | SLC25A19 | solute carrier family 25 member 19 | ENCODES a protein that exhibits deoxynucleotide transmembrane transporter activity (ortholog); INVOLVED IN deoxynucleotide transport (ortholog); ASSOCIATED WITH Amish Lethal Microcephaly (ortholog); genetic disease (ortholog); microcephaly (ortholog); FOUND IN membrane (inferred); mitochondrial inne r membrane (inferred); mitochondrial membrane (inferred) | 17 | 69220073 | 69237067 | Bonobo | 21 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12353415 | SLC25A19 | solute carrier family 25 member 19 | ENCODES a protein that exhibits deoxynucleotide transmembrane transporter activity (ortholog); INVOLVED IN deoxynucleotide transport (ortholog); ASSOCIATED WITH Amish Lethal Microcephaly (ortholog); genetic disease (ortholog); microcephaly (ortholog); FOUND IN membrane (inferred); mitochondrial inne r membrane (inferred); mitochondrial membrane (inferred) | 9 | 5208982 | 5226925 | Dog | 24 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12663330 | Slc25a19 | solute carrier family 25 member 19 | ENCODES a protein that exhibits deoxynucleotide transmembrane transporter activity (ortholog); thiamine pyrophosphate transmembrane transporter activity (ortholog); INVOLVED IN deoxynucleotide transport (ortholog); thiamine diphosphate biosynthetic process (ortholog); thiamine pyrophosphate transmem brane transport (ortholog); ASSOCIATED WITH Amish Lethal Microcephaly (ortholog); genetic disease (ortholog); microcephaly (ortholog); FOUND IN mitochondrial inner membrane (ortholog); mitochondrion (ortholog) | NW_004936594 | 557823 | 570599 | Squirrel | 18 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 155238776 | slc25a19 | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 625833125 | Slc25a19 | solute carrier family 25 member 19 | ENCODES a protein that exhibits deoxynucleotide transmembrane transporter activity (ortholog); thiamine pyrophosphate transmembrane transporter activity (ortholog); INVOLVED IN deoxynucleotide transport (ortholog); thiamine diphosphate biosynthetic process (ortholog); thiamine pyrophosphate transmem brane transport (ortholog); ASSOCIATED WITH Amish Lethal Microcephaly (ortholog); genetic disease (ortholog); microcephaly (ortholog); FOUND IN mitochondrial inner membrane (ortholog); mitochondrion (ortholog) | | | | Black Rat | 16 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18536351 | SLC25A19 | solute carrier family 25 member 19 | ENCODES a protein that exhibits deoxynucleotide transmembrane transporter activity (ortholog); INVOLVED IN deoxynucleotide transport (ortholog); ASSOCIATED WITH Amish Lethal Microcephaly (ortholog); genetic disease (ortholog); microcephaly (ortholog); FOUND IN membrane (inferred); mitochondrial inne r membrane (inferred); mitochondrial membrane (inferred) | | | | Green Monkey | 20 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18908207 | Slc25a19 | solute carrier family 25 member 19 | ENCODES a protein that exhibits deoxynucleotide transmembrane transporter activity (ortholog); INVOLVED IN deoxynucleotide transport (ortholog); ASSOCIATED WITH Amish Lethal Microcephaly (ortholog); genetic disease (ortholog); microcephaly (ortholog); FOUND IN membrane (inferred); mitochondrial inne r membrane (inferred); mitochondrial membrane (inferred) | | | | Naked Mole-Rat | 22 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 13941689 | SLC25A19 | solute carrier family 25 member 19 | ENCODES a protein that exhibits deoxynucleotide transmembrane transporter activity (ortholog); INVOLVED IN deoxynucleotide transport (ortholog); ASSOCIATED WITH Amish Lethal Microcephaly (ortholog); genetic disease (ortholog); microcephaly (ortholog); FOUND IN membrane (inferred); mitochondrial inne r membrane (inferred); mitochondrial membrane (inferred); INTERACTS WITH deoxynivalenol | | | | Pig | 25 | symbol | gene, protein-coding, PROVISIONAL [RefSeq] |
| 155238775 | slc25a19.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 7566111 | Slc25a19-ps1 | solute carrier family 25 member 19, pseudogene 1 | | 18 | 3380714 | 3381711 | Rat | | symbol , PhenoGen | gene, pseudo, MODEL [RefSeq] |
| 16563810 | MIF4GD-DT | MIF4GD divergent transcript | | 17 | 75271299 | 75273895 | Human | | old_gene_name | gene, ncrna, VALIDATED [RefSeq] |
| 1561206 | Slc25a19l1 | solute carrier family 25 member 19 like 1 | INVOLVED IN transmembrane transport (inferred); FOUND IN membrane (inferred); mitochondrion (inferred); INTERACTS WITH bisphenol A; thioacetamide | 1 | 120648675 | 120650494 | Rat | 6 | symbol , PhenoGen | gene, protein-coding, MODEL [RefSeq] |