| 620578 | Sh3gl3 | SH3 domain containing GRB2 like 3, endophilin A3 | ENCODES a protein that exhibits identical protein binding (ortholog); INVOLVED IN negative regulation of clathrin-dependent endocytosis; positive regulation of neuron differentiation; regulation of clathrin-dependent endocytosis; PARTICIPATES IN clathrin-dependent synaptic vesicle endocytosis; endoc ytosis pathway; FOUND IN acrosomal vesicle; early endosome; glutamatergic synapse; INTERACTS WITH (+)-schisandrin B; 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine | 1 | 145533728 | 145664881 | Rat | 126 | symbol , PhenoGen | gene, protein-coding, VALIDATED [RefSeq] |
| 731323 | SH3GL3 | SH3 domain containing GRB2 like 3, endophilin A3 | Enables identical protein binding activity. Predicted to be involved in central nervous system development and signal transduction. Predicted to be located in acrosomal vesicle and early endosome membrane. Predicted to be part of early endosome. Predicted to be active in several cellular components, including glutamatergic synapse; postsynaptic density, intracellular component; and postsynaptic endosome. [provided by Alliance of Genome Resources, Apr 2025] | 15 | 83447341 | 83633820 | Human | 133 | symbol , COSMIC , Human Proteome Map | gene, protein-coding, VALIDATED [RefSeq] |
| 1551861 | Sh3gl3 | SH3-domain GRB2-like 3 | Predicted to enable identical protein binding activity. Predicted to be involved in negative regulation of clathrin-dependent endocytosis and positive regulation of neuron differentiation. Located in cytoplasm. Is expressed in several structures, including adrenal gland; central nervous system; dors al aorta; peripheral nervous system; and testis. Orthologous to human SH3GL3 (SH3 domain containing GRB2 like 3, endophilin A3). [provided by Alliance of Genome Resources, Jul 2025] | 7 | 81824581 | 81956618 | Mouse | 134 | symbol , PhenoGen , description | gene, protein-coding, VALIDATED [RefSeq] |
| 8755936 | Sh3gl3 | SH3 domain containing GRB2 like 3, endophilin A3 | ENCODES a protein that exhibits identical protein binding (ortholog); INVOLVED IN negative regulation of clathrin-dependent endocytosis (ortholog); positive regulation of neuron differentiation (ortholog); regulation of clathrin-dependent endocytosis (ortholog); PARTICIPATES IN clathrin-dependent sy naptic vesicle endocytosis; FOUND IN acrosomal vesicle (ortholog); cytoplasm (ortholog); early endosome (ortholog) | NW_004955416 | 13151288 | 13297878 | Chinchilla | 30 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 11843369 | SH3GL3 | SH3 domain containing GRB2 like 3, endophilin A3 | ENCODES a protein that exhibits identical protein binding (inferred); lipid binding (inferred); INVOLVED IN negative regulation of clathrin-dependent endocytosis (ortholog); positive regulation of neuron differentiation (ortholog); regulation of clathrin-dependent endocytosis (ortholog); PARTICIPATE S IN clathrin-dependent synaptic vesicle endocytosis; FOUND IN acrosomal vesicle (ortholog); early endosome (ortholog); glutamatergic synapse (ortholog) | 15 | 61988584 | 62153543 | Bonobo | 41 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12138124 | SH3GL3 | SH3 domain containing GRB2 like 3, endophilin A3 | ENCODES a protein that exhibits identical protein binding (ortholog); INVOLVED IN negative regulation of clathrin-dependent endocytosis (ortholog); positive regulation of neuron differentiation (ortholog); regulation of clathrin-dependent endocytosis (ortholog); PARTICIPATES IN clathrin-dependent sy naptic vesicle endocytosis; FOUND IN acrosomal vesicle (ortholog); early endosome (ortholog); glutamatergic synapse (ortholog) | 3 | 55287460 | 55340736 | Dog | 38 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12710646 | Sh3gl3 | SH3 domain containing GRB2 like 3, endophilin A3 | ENCODES a protein that exhibits identical protein binding (inferred); lipid binding (inferred); INVOLVED IN negative regulation of clathrin-dependent endocytosis (ortholog); positive regulation of neuron differentiation (ortholog); regulation of clathrin-dependent endocytosis (ortholog); PARTICIPATE S IN clathrin-dependent synaptic vesicle endocytosis; FOUND IN acrosomal vesicle (ortholog); early endosome (ortholog); glutamatergic synapse (ortholog) | NW_004936483 | 18051023 | 18176514 | Squirrel | 40 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 14025740 | SH3GL3 | SH3 domain containing GRB2 like 3, endophilin A3 | ENCODES a protein that exhibits identical protein binding (inferred); lipid binding (inferred); INVOLVED IN negative regulation of clathrin-dependent endocytosis (ortholog); positive regulation of neuron differentiation (ortholog); regulation of clathrin-dependent endocytosis (ortholog); PARTICIPATE S IN clathrin-dependent synaptic vesicle endocytosis; FOUND IN acrosomal vesicle (ortholog); early endosome (ortholog); postsynaptic density, intracellular component (ortholog) | | | | Pig | 42 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 155240365 | sh3gl3 | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 18530776 | SH3GL3 | SH3 domain containing GRB2 like 3, endophilin A3 | ENCODES a protein that exhibits identical protein binding (inferred); lipid binding (inferred); INVOLVED IN negative regulation of clathrin-dependent endocytosis (ortholog); positive regulation of neuron differentiation (ortholog); regulation of clathrin-dependent endocytosis (ortholog); PARTICIPATE S IN clathrin-dependent synaptic vesicle endocytosis; FOUND IN acrosomal vesicle (ortholog); early endosome (ortholog); glutamatergic synapse (ortholog) | | | | Green Monkey | 41 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18934703 | Sh3gl3 | SH3 domain containing GRB2 like 3, endophilin A3 | ENCODES a protein that exhibits identical protein binding (ortholog); INVOLVED IN negative regulation of clathrin-dependent endocytosis (ortholog); positive regulation of neuron differentiation (ortholog); regulation of clathrin-dependent endocytosis (ortholog); PARTICIPATES IN clathrin-dependent sy naptic vesicle endocytosis; FOUND IN acrosomal vesicle (ortholog); early endosome (ortholog); glutamatergic synapse (ortholog) | | | | Naked Mole-Rat | 40 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 626090372 | Sh3gl3 | SH3 domain containing GRB2 like 3, endophilin A3 | ENCODES a protein that exhibits identical protein binding (ortholog); INVOLVED IN negative regulation of clathrin-dependent endocytosis (ortholog); positive regulation of neuron differentiation (ortholog); regulation of clathrin-dependent endocytosis (ortholog); PARTICIPATES IN clathrin-dependent sy naptic vesicle endocytosis; FOUND IN acrosomal vesicle (ortholog); cytoplasm (ortholog); early endosome (ortholog) | | | | Black Rat | 30 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 155247948 | sh3gl3.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 155240366 | sh3gl3.S | | | | | | African Clawed Frog | | symbol | gene, null |
| 1616833 | Sh3d2c-ps1 | SH3 domain protein 2C, pseudogene 1 | | 2 | 23570160 | 23571602 | Mouse | | old_gene_symbol | gene, pseudo, INFERRED [RefSeq] |
| 1346308 | SGIP1 | SH3GL interacting endocytic adaptor 1 | SGIP1 functions as an endocytic protein that affects signaling by receptors in neuronal systems involved in energy homeostasis via its interaction with endophilins (see SH3GL3; MIM 603362) (Trevaskis et al., 2005 [PubMed 15919751] and Uezu et al., 2007 [PubMed 1 7626015]).[supplied by OMIM, Mar 2008] | 1 | 66533361 | 66751139 | Human | 84 | description | gene, protein-coding, VALIDATED [RefSeq] |