| 1306275 | Sh3bp1 | SH3-domain binding protein 1 | ENCODES a protein that exhibits GTPase activator activity; semaphorin receptor binding (ortholog); SH3 domain binding (ortholog); INVOLVED IN cell migration; filopodium assembly; positive regulation of GTPase activity; FOUND IN cell leading edge; adherens junction (ortholog); bicellular tight juncti on (ortholog); INTERACTS WITH 17beta-estradiol; 17beta-estradiol 3-benzoate; 2,3,7,8-tetrachlorodibenzodioxine | 7 | 112338087 | 112350659 | Rat | 118 | symbol , PhenoGen , old_gene_symbol | gene, protein-coding, VALIDATED [RefSeq] |
| 1314801 | SH3BP1 | SH3 domain binding protein 1 | This gene encodes a member of the Rho GTPase activating protein (RhoGAP) family. The encoded protein regulates Rac signaling and plays a role in cytoskeletal dynamics, cell motility and epithelial junction formation. This protein's association with the exocyst complex, which tethers secretory vesicl es to the plasma membrane, has been demonstrated to be important in cell motility. In a distinct complex, this protein has been shown to regulate epithelial junction formation and morphogenesis. By interacting with the Plexin-D1 cell surface receptor, this protein mediates changes in the cytoskeleton in response to semaphorin binding. This protein may promote metastasis in human liver cancer cells and tissues. [provided by RefSeq, Mar 2017] | 22 | 37639669 | 37656117 | Human | 102 | symbol , COSMIC , Human Proteome Map | gene, protein-coding, REVIEWED [RefSeq] |
| 1314802 | Sh3bp1 | SH3-domain binding protein 1 | Enables GTPase activator activity and SH3 domain binding activity. Involved in positive regulation of GTPase activity and ruffle assembly. Located in bicellular tight junction. Orthologous to human SH3BP1 (SH3 domain binding protein 1). [provided by Alliance of Genome Resources, Jul 2025] | 15 | 78783994 | 78796247 | Mouse | 138 | symbol , PhenoGen , description | gene, protein-coding, VALIDATED [RefSeq] |
| 8836750 | Sh3bp1 | SH3 domain binding protein 1 | ENCODES a protein that exhibits GTPase activator activity (ortholog); semaphorin receptor binding (ortholog); SH3 domain binding (ortholog); INVOLVED IN actin filament organization (ortholog); cell junction assembly (ortholog); cell migration (ortholog); FOUND IN adherens junction (ortholog); bicell ular tight junction (ortholog); cell leading edge (ortholog) | NW_004955413 | 24042875 | 24054826 | Chinchilla | 33 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12294423 | SH3BP1 | SH3 domain binding protein 1 | ENCODES a protein that exhibits GTPase activator activity (inferred); semaphorin receptor binding (inferred); SH3 domain binding (inferred); INVOLVED IN filopodium assembly (ortholog); positive regulation of GTPase activity (ortholog); FOUND IN adherens junction (inferred); bicellular tight junction (inferred); cell leading edge (inferred) | 10 | 26953993 | 26966417 | Dog | 40 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12728099 | Sh3bp1 | SH3 domain binding protein 1 | ENCODES a protein that exhibits GTPase activator activity (inferred); semaphorin receptor binding (inferred); SH3 domain binding (inferred); INVOLVED IN filopodium assembly (ortholog); positive regulation of GTPase activity (ortholog); FOUND IN adherens junction (inferred); bicellular tight junction (inferred); cell leading edge (inferred) | NW_004936492 | 3430099 | 3440432 | Squirrel | 42 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 284864812 | sh3bp1 | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 18928243 | Sh3bp1 | SH3 domain binding protein 1 | ENCODES a protein that exhibits semaphorin receptor binding (ortholog); SH3 domain binding (ortholog); INVOLVED IN actin filament organization (ortholog); cell junction assembly (ortholog); cell migration (ortholog); FOUND IN bicellular tight junction (ortholog); cell leading edge (ortholog); exocys t (ortholog) | | | | Naked Mole-Rat | 40 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 14097178 | SH3BP1 | SH3 domain binding protein 1 | ENCODES a protein that exhibits GTPase activator activity (inferred); semaphorin receptor binding (inferred); SH3 domain binding (inferred); INVOLVED IN filopodium assembly (ortholog); positive regulation of GTPase activity (ortholog); FOUND IN adherens junction (inferred); bicellular tight junction (inferred); cell leading edge (inferred) | | | | Pig | 40 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 288061164 | sh3bp1.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 329329250 | sh3bp1.S | | | | | | African Clawed Frog | | symbol | gene, null |
| 11740501 | LOC100968722 | chronophin | ENCODES a protein that exhibits GTPase activator activity (inferred); semaphorin receptor binding (inferred); SH3 domain binding (inferred); INVOLVED IN filopodium assembly (ortholog); positive regulation of GTPase activity (ortholog); FOUND IN adherens junction (inferred); bicellular tight junction (inferred); cell leading edge (inferred) | 22 | 18552737 | 18585014 | Bonobo | 39 | old_gene_symbol | gene, protein-coding, MODEL [RefSeq] |
| 18694314 | LOC103223283 | chronophin | ENCODES a protein that exhibits GTPase activator activity (inferred); heat shock protein binding (inferred); hydrolase activity (inferred); INVOLVED IN filopodium assembly (ortholog); positive regulation of GTPase activity (ortholog); FOUND IN actin cytoskeleton (inferred); adherens junction (inferr ed); bicellular tight junction (inferred) | | | | Green Monkey | 70 | old_gene_symbol | gene, protein-coding, MODEL [RefSeq] |