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Gene: SH3BP1 (SH3 domain binding protein 1) Homo sapiens
Symbol: SH3BP1
Name: SH3 domain binding protein 1
Description: Exhibits GTPase activator activity and semaphorin receptor binding activity. Involved in several processes, including establishment of epithelial cell apical/basal polarity; positive regulation of GTPase activity; and regulation of blood vessel endothelial cell migration. Localizes to several cellular components, including adherens junction; bicellular tight junction; and phagocytic cup. Colocalizes with exocyst.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: 3BP-1; ARHGAP43; BGIN; SH3 domain-binding protein 1; SH3-domain binding protein 1
Mus musculus (house mouse) : Sh3bp1 (SH3-domain binding protein 1)  MGI  Alliance
Rattus norvegicus (Norway rat) : Sh3bp1 (SH3-domain binding protein 1)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Sh3bp1 (SH3 domain binding protein 1)
Pan paniscus (bonobo/pygmy chimpanzee) : LOC100968722 (pyridoxal phosphate phosphatase)
Canis lupus familiaris (dog) : SH3BP1 (SH3 domain binding protein 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Sh3bp1 (SH3 domain binding protein 1)
Sus scrofa (pig) : SH3BP1 (SH3 domain binding protein 1)
Chlorocebus sabaeus (African green monkey) : SH3BP1 (SH3 domain binding protein 1)
Heterocephalus glaber (naked mole-rat) : Sh3bp1 (SH3 domain binding protein 1)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38.p13 Ensembl2237,634,654 - 37,656,119 (+)EnsemblGRCh38hg38GRCh38
GRCh382237,639,669 - 37,656,117 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh372238,030,661 - 38,052,119 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362236,365,630 - 36,381,996 (+)NCBINCBI36hg18NCBI36
Build 342236,361,877 - 36,376,545NCBI
Celera2221,837,548 - 21,853,915 (+)NCBI
Cytogenetic Map22q13.1NCBI
HuRef2221,002,814 - 21,018,998 (+)NCBIHuRef
CHM1_12237,994,433 - 38,010,794 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Gene-Chemical Interaction Annotations
Gene Ontology Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
Nomenclature History
More on SH3BP1
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1314801
Created: 2005-01-12
Species: Homo sapiens
Last Modified: 2020-07-28
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.